PMID- 28219858
OWN - NLM
STAT- MEDLINE
DCOM- 20171019
LR  - 20200612
IS  - 1673-4254 (Print)
IS  - 2663-0842 (Electronic)
IS  - 1673-4254 (Linking)
VI  - 37
IP  - 2
DP  - 2016 Feb 20
TI  - [Sensitivity and specificity of optical coherence tomography in diagnosing 
      polypoidal choroidal vasculopathy].
PG  - 165-171
AB  - OBJECTIVE: To establish the diagnostic criteria for polypoidal choroidal 
      vasculopathy (PCV) based on spectral-domain optical coherence tomography (SD OCT) 
      by evaluating the sensitivity and specificity of SD OCT in differentiating PCV 
      from wet age-related macular degeneration (wAMD). METHODS: The clinical data were 
      reviewed for 62 patients (63 eyes) with the initial diagnosis of PCV or wAMD 
      between August, 2012 and June, 2016. Twenty-four patients (25 eyes) were 
      diagnosed to have PCV and 38 (38 eyes) had wAMD based on findings by fundus 
      photography, fluorescein angiography (FFA) and indocyanine green angiography 
      (ICGA). Among the 6 features of SD OCT, namely a sharp RPED peak, double-layer 
      sign, multiple RPED, an RPED notch, a hyporeflective lumen representing polyps, 
      and hyperreflective intraretinal hard exudates, findings of the first two 
      features and at least one of the other features sufficed the diagnosis of PCV; in 
      the absence of the first two features, the diagnosis of PCV was also made when at 
      least 3 of the other features were present simultaneously. The sensitivity and 
      specificity of SD OCT-based diagnosis were estimated by comparison with the gold 
      standard ICGA-based diagnosis. RESULTS: In the 25 eyes with an established 
      diagnosis of PCV, 23 eyes (92.0%) met the diagnostic criteria based on SD OCT 
      findings; in the 38 eyes with the diagnosis of wAMD, only 4 eyes (10.5%) met the 
      criteria. The sensitivity and specificity of SD OCT-based diagnosis of PCV was 
      92.0% and 89.5%, respectively. CONCLUSION: s We established the diagnostic 
      criteria for PCV based on SD OCT findings with a high sensitivity and 
      specificity. SD OCT shows a strong capacity for differentiating PCV from wAMD.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Department of Ophthalmology, Second Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an710004, China. E-mail: 1207373764@qq.com.
FAU - Yao, Jing
AU  - Yao J
FAU - Wang, Xiao-Hua
AU  - Wang XH
FAU - Zhao, Lin
AU  - Zhao L
FAU - Wang, Li-Jun
AU  - Wang LJ
FAU - Wang, Jian-Ming
AU  - Wang JM
FAU - Zhou, Ai-Yi
AU  - Zhou AY
LA  - chi
PT  - Journal Article
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
SB  - IM
MH  - Choroid/diagnostic imaging
MH  - Choroidal Neovascularization/*diagnostic imaging
MH  - Diagnosis, Differential
MH  - Fluorescein Angiography
MH  - Humans
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - *Tomography, Optical Coherence
PMC - PMC6779675
EDAT- 2017/02/22 06:00
MHDA- 2017/10/20 06:00
PMCR- 2017/02/20
CRDT- 2017/02/22 06:00
PHST- 2017/02/22 06:00 [entrez]
PHST- 2017/02/22 06:00 [pubmed]
PHST- 2017/10/20 06:00 [medline]
PHST- 2017/02/20 00:00 [pmc-release]
AID - nfykdxxb-37-2-165 [pii]
AID - 10.3969/j.issn.1673-4254.2017.02.04 [doi]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2016 Feb 20;37(2):165-171. doi: 
      10.3969/j.issn.1673-4254.2017.02.04.