PMID- 28221461
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Linking)
VI  - 15
IP  - 5
DP  - 2005 Sep - Oct 2005
TI  - Topical nonsteroidal anti-inflammatory drugs in uncomplicated cataract surgery: 
      Effect of sodium naproxen.
PG  - 598-606
LID - 10.5301/EJO.2008.1599 [doi]
AB  - PURPOSE: To investigate whether topical nonsteroidal antiinflammatory drugs 
      (NSAIDs) are useful, in the absence of concomitant corticosteroid therapy, in 
      limiting postoperative inflammation after uncomplicated cataract surgery. 
      METHODS: A total of 328 patients were enrolled in a prospective, randomized, 
      double-masked, parallel-group, active-controlled study. Anterior chamber 
      inflammation (ACI) was evaluated as the primary efficacy parameter. Only patients 
      with moderate inflammation (ACI score of <=4) the day after surgery were 
      randomized and treated with NSAIDs. A novel topical formulation containing 0.2% 
      sodium naproxen was compared with 0.1% diclofenac. Both were administered three 
      times a day for 14 consecutive days. Ocular inflammation was measured after 7 and 
      14 days by using slit-lamp biomicroscopy. Safety parameters were also evaluated 
      at the same time. RESULTS: Both treatments were equally effective in controlling 
      postsurgical inflammation. No statistically significant differences between 
      treatment groups were observed for the safety variables. No serious adverse 
      events (AEs) occurred during the course of the study. The most frequent AE 
      reported with naproxen was eye redness. CONCLUSIONS: NSAIDs can effectively be 
      used without concurrent administration of corticosteroids to control 
      postoperative inflammation after uncomplicated cataract surgery. In addition, 
      naproxen ophthalmic solution may be considered a suitable alternative to the 
      currently available NSAIDs. (Eur J Ophthalmol 2005; 15: 598-606).
FAU - Russo, P
AU  - Russo P
AD  - Medical Department SIFI SpA, Catania - Italy.
FAU - Papa, V
AU  - Papa V
FAU - Russo, S
AU  - Russo S
FAU - Di Bella, A
AU  - Di Bella A
FAU - Pabst, G
AU  - Pabst G
FAU - Milazzo, G
AU  - Milazzo G
FAU - Balestrazzi, A
AU  - Balestrazzi A
FAU - Caporossi, A
AU  - Caporossi A
FAU - The Naproxen Study Group, For
AU  - The Naproxen Study Group F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
EDAT- 2005/09/01 00:00
MHDA- 2005/09/01 00:01
CRDT- 2017/02/22 06:00
PHST- 2017/02/22 06:00 [entrez]
PHST- 2005/09/01 00:00 [pubmed]
PHST- 2005/09/01 00:01 [medline]
AID - B1853003-BA05-4B3D-A36B-2E5AE5934960 [pii]
AID - 10.5301/EJO.2008.1599 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2005 Sep - Oct 2005;15(5):598-606. doi: 10.5301/EJO.2008.1599.