PMID- 28221462
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Linking)
VI  - 15
IP  - 5
DP  - 2005 Sep - Oct 2005
TI  - A new, heavier-than-water silicone oil: A solution of perfluorohexyloctane in 
      polydimethylsiloxane.
PG  - 627-637
LID - 10.5301/EJO.2008.2829 [doi]
AB  - PURPOSE: To pre p a re and explore new solutions of semifluorinated alkane in 
      silicone oil, which have a specific gravity slightly higher than silicone oil and 
      vitreous fluid (referred to in the following as heavier-than-water silicone oils 
      (HWSs), and to investigate, in vitro, whether HWSs can be used to plug retina 
      holes, while allowing dehydration of the subretinal space. METHODS: HWS solutions 
      were pre p a red with silicone oil 5000 and perfluorohexyloctane (F6H8). The 
      stabiliy was investigated under different conditions. The viscosity was 
      determined by means of a capillary viscometer. The surface and interface tension 
      were measured using the ring method. RESULTS: HWSs are insoluble in an aqueous 
      medium. Densiron68 (HWS 1.06) is a transparent homogeneous liquid which is 
      slightly heavier (1.06 g/cm3) than water and has a refractive index close to that 
      of vitreous liquid. Densiron68 (HWS 1.06) has a low viscosity (1480 mPas) and 
      interface tension (40.82 mN/m), making it an effective tamponade in the surgical 
      treatment of an inferior detached retina. In addition, the interfaces between 
      Densiron68 and other perfluorocarbon liquids are clearly visible. However, the 
      interface layer between Densiron68 and water is not clear. Finally, all HWSs are 
      stable over the long term at ambient temperatures, as well as physically and 
      thermally resistant. CONCLUSIONS: Due to its physiochemical properties, 
      Densiron68 could meet the requirements for a heavier-than-water tamponade. (Eur J 
      Ophthalmol 2005; 15: 627-37).
FAU - Kim, Y K
AU  - Kim YK
AD  - Fluoron GmbH, Neu-Ulm - Germany.
FAU - Gunther, B
AU  - Gunther B
FAU - Meinert, H
AU  - Meinert H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
EDAT- 2005/09/01 00:00
MHDA- 2005/09/01 00:01
CRDT- 2017/02/22 06:00
PHST- 2017/02/22 06:00 [entrez]
PHST- 2005/09/01 00:00 [pubmed]
PHST- 2005/09/01 00:01 [medline]
AID - 37811A75-C812-4D20-B10A-285B4AE8BF83 [pii]
AID - 10.5301/EJO.2008.2829 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2005 Sep - Oct 2005;15(5):627-637. doi: 10.5301/EJO.2008.2829.