PMID- 28223199
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20210707
IS  - 1879-176X (Electronic)
IS  - 0300-5712 (Linking)
VI  - 59
DP  - 2017 Apr
TI  - Poly(methyl methacrylate) with TiO(2) nanoparticles inclusion for 
      stereolitographic complete denture manufacturing - the fututre in dental care for 
      elderly edentulous patients?
PG  - 68-77
LID - S0300-5712(17)30040-4 [pii]
LID - 10.1016/j.jdent.2017.02.012 [doi]
AB  - OBJECTIVES: The aim of this study was to obtain a Poly(methylmethacrylate) 
      (PMMA)-TiO(2) nanocomposite material with improved antibacterial characteristics, 
      suitable for manufacturing 3D printed dental prosthesis. METHODS: 0.2, 0.4, 0.6, 
      1, 2.5 by weight% of TiO(2) nanoparticles have been added to the commercially 
      available stereolithographic PMMA material and the obtained nanocomposites have 
      been analyzed using FTIR, SEM and also tested for antimicrobial efficacy against 
      bacterial cultures from Candida species (C. scotti). RESULTS: SEM images and EDX 
      results highlighted the presence of TiO(2) in PMMA nanocomposites. The elemental 
      composition (EDX) also showed the presence of other fillers included in 
      stereolithographic PMMA solution. FTIR analysis clearly revealed changes in 
      polymeric matrix structure when adding TiO(2) nanoparticles. Sample containing 
      0.4, 1 and 2.5wt% TiO(2) nanoparticles inhibited the growth of Candida scotti 
      strain in standard conditions according to the toxicity control method (DHA). 
      Increasing quantity of nano-titania has resulted in particles fooling, forming 
      new aggregates instead of the homogenous dispersion of nanoparticles with 
      modified viscosity characteristics and expected lower mechanical parameters. 
      CONCLUSIONS: Significant improvements in polymer characteristics and nice 
      dispersion of the TiO(2) nanoparticles have been noticed for 0.4wt%, therefore it 
      was used for stereolitographic complete denture prototyping. CLINICAL 
      SIGNIFICANCE: Incorporation of TiO(2) nanoparticles in PMMA polymer matrix was 
      proved to have antibacterial effects, specifically on Candida species. The newly 
      obtained 0.4% nanocomposite was successfully used with stereolitographic 
      technique for complete denture manufacturing. However, mechanical and 
      biocompatibility tests need to be performed in order to extend the clinical 
      usage.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Totu, Eugenia Eftimie
AU  - Totu EE
AD  - Dept. of Analytical Chemistry and Environment Engineering, Faculty of Applied 
      Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu 
      St., 1, Bucharest, Romania. Electronic address: eugenia_totu@yahoo.com.
FAU - Nechifor, Aurelia Cristina
AU  - Nechifor AC
AD  - Dept. of Analytical Chemistry and Environment Engineering, Faculty of Applied 
      Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu 
      St., 1, Bucharest, Romania. Electronic address: nechiforus@yahoo.com.
FAU - Nechifor, Gheorghe
AU  - Nechifor G
AD  - Dept. of Analytical Chemistry and Environment Engineering, Faculty of Applied 
      Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu 
      St., 1, Bucharest, Romania. Electronic address: doru.nechifor@yahoo.com.
FAU - Aboul-Enein, Hassan Y
AU  - Aboul-Enein HY
AD  - Pharmaceutical and Medicinal Chemistry Department, Pharamceutical and Drug 
      Industries Research Division, National Research Centre, Dokki, Giza 12622, 
      Egypt,. Electronic address: haboulenein@yahoo.com.
FAU - Cristache, Corina Marilena
AU  - Cristache CM
AD  - Faculty of Midwifery and Medical Assisting, "Carol Davila" University of Medicine 
      and Pharmacy, 8, Blvd Eroilor Sanitari, 050474, Bucharest, Romania,. Electronic 
      address: corinacristache@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20170220
PL  - England
TA  - J Dent
JT  - Journal of dentistry
JID - 0354422
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Dental Materials)
RN  - 0 (Polymers)
RN  - 15FIX9V2JP (titanium dioxide)
RN  - 9011-14-7 (Polymethyl Methacrylate)
RN  - D1JT611TNE (Titanium)
SB  - IM
EIN - J Dent. 2021 Sep;112:103739. PMID: 34229935
MH  - Anti-Bacterial Agents/chemistry/pharmacology
MH  - Bacteria/drug effects
MH  - Candida/drug effects
MH  - Computer-Aided Design
MH  - *Dental Care for Aged
MH  - Dental Materials/chemistry
MH  - Dental Prosthesis
MH  - Denture Bases
MH  - *Denture, Complete
MH  - Humans
MH  - Materials Testing
MH  - Microbial Sensitivity Tests
MH  - *Mouth, Edentulous
MH  - Nanocomposites/*chemistry
MH  - Nanoparticles/chemistry
MH  - Polymers/chemistry
MH  - Polymethyl Methacrylate/*chemistry
MH  - *Stereolithography
MH  - Stress, Mechanical
MH  - Surface Properties
MH  - Titanium/*chemistry/pharmacology
MH  - Viscosity
OTO - NOTNLM
OT  - 3D printing
OT  - Antibacterial nanoparticles
OT  - Complete denture
OT  - Elderly patients
OT  - PMMA-TiO(2) nanocomposite
EDAT- 2017/02/23 06:00
MHDA- 2018/05/08 06:00
CRDT- 2017/02/23 06:00
PHST- 2016/11/02 00:00 [received]
PHST- 2017/02/07 00:00 [revised]
PHST- 2017/02/16 00:00 [accepted]
PHST- 2017/02/23 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2017/02/23 06:00 [entrez]
AID - S0300-5712(17)30040-4 [pii]
AID - 10.1016/j.jdent.2017.02.012 [doi]
PST - ppublish
SO  - J Dent. 2017 Apr;59:68-77. doi: 10.1016/j.jdent.2017.02.012. Epub 2017 Feb 20.