PMID- 2822470
OWN - NLM
STAT- MEDLINE
DCOM- 19871215
LR  - 20190908
IS  - 0902-4441 (Print)
IS  - 0902-4441 (Linking)
VI  - 39
IP  - 2
DP  - 1987 Aug
TI  - Colony-stimulating factor and leukemia cell-growth factor produced by a murine 
      endothelial cell line, MKM-O.
PG  - 136-43
AB  - A murine cultured cell line (MKM-O) was established from a tumor of a BALB/C 
      (nu/nu) mouse that had been subcutaneously inoculated with human hepatoma tissue 
      fragments in the same location. The MKM-O cell line was proven to be of 
      endothelial origin by morphological examinations and positive staining with 
      fluorescein-labeled antibody against factor VIII antigen. MKM-O cells grown in 
      vitro produced a colony-stimulating factor (CSF) and a leukemia cell-growth 
      factor (LC-GF). CSF from MKM-O acted on both human and murine bone marrow-derived 
      granulocytes and macrophage colony-forming units (CFU-GM). The activity of LC-GF 
      on human leukemia cell lines (HL-60, HSB-2, CEM, DAUDI and K562) was demonstrated 
      both in conditioned medium (CM) of MKM-O and of rat vascular endothelial cells. 
      The CM of MKM-O also demonstrated a limited growth promoting activity against the 
      mononuclear cells from human cord blood and improved their survival, suggesting 
      that endothelial cells play an important role in the proliferation and 
      differentiation of blood cells.
FAU - Yoshimura, T
AU  - Yoshimura T
AD  - Department of Pediatrics, Kyoto University, Japan.
FAU - Miyanomae, T
AU  - Miyanomae T
FAU - Tanaka, M
AU  - Tanaka M
FAU - Iwai, Y
AU  - Iwai Y
FAU - Mayumi, M
AU  - Mayumi M
FAU - Mikawa, H
AU  - Mikawa H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Haematol
JT  - European journal of haematology
JID - 8703985
RN  - 0 (Colony-Stimulating Factors)
RN  - 0 (Growth Substances)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (leukemia growth-promoting factor)
SB  - IM
MH  - Animals
MH  - Carcinoma, Hepatocellular/metabolism
MH  - Colony-Stimulating Factors/*biosynthesis
MH  - Endothelium
MH  - Female
MH  - Fetal Blood/metabolism
MH  - Fluorescent Antibody Technique
MH  - Granulocytes/metabolism
MH  - Growth Substances/*biosynthesis
MH  - Humans
MH  - *Intercellular Signaling Peptides and Proteins
MH  - Leukemia/metabolism
MH  - Leukocytes, Mononuclear/metabolism
MH  - Liver Neoplasms/metabolism
MH  - Macrophages/metabolism
MH  - Mice
MH  - Mice, Nude
MH  - Transplantation, Heterologous
MH  - Tumor Cells, Cultured/cytology/*metabolism
EDAT- 1987/08/01 00:00
MHDA- 1987/08/01 00:01
CRDT- 1987/08/01 00:00
PHST- 1987/08/01 00:00 [pubmed]
PHST- 1987/08/01 00:01 [medline]
PHST- 1987/08/01 00:00 [entrez]
AID - 10.1111/j.1600-0609.1987.tb00743.x [doi]
PST - ppublish
SO  - Eur J Haematol. 1987 Aug;39(2):136-43. doi: 10.1111/j.1600-0609.1987.tb00743.x.