PMID- 28225775
OWN - NLM
STAT- MEDLINE
DCOM- 20170821
LR  - 20220316
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 2
DP  - 2017
TI  - Genetic polymorphisms and plasma levels of BCL11A contribute to the development 
      of laryngeal squamous cell carcinoma.
PG  - e0171116
LID - 10.1371/journal.pone.0171116 [doi]
LID - e0171116
AB  - OBJECTIVE: We investigated the association between B-cell lymphoma/leukaemia 11A 
      (BCL11A) rs11886868 and rs4671393 polymorphism, plasma BCL11A concentration, and 
      the hazard of developing laryngeal squamous cell carcinoma (LSCC). PARTICIPANTS 
      AND METHOD: In this research, 330 LSCC patients, 310 healthy controls, and 155 
      vocal leukoplakia patients were genotyped for the BCL11A (rs11886868 C/T and 
      rs4671393 A/G) genotypes by pyrosequencing; the BCL11A concentration was measured 
      using ELISA. RESULTS: LSCC Patients had a notably higher occurrence of CT at 
      rs11886868 (OR = 2.64, P = 0.025) than the control group; they also had higher GG 
      at rs4671393 (OR = 2.53, P = 0.018). Advanced (III and IV) stage LSCC patients 
      had a notably greater frequency of CT at rs11886868 than those with initial (I 
      and II) stage LSCC (OR = 2.71, P = 0.044 vs. OR = 2.58, P = 0.051). Additionally, 
      there was a 1.59 fold increase in susceptibility for initial stage LSCC related 
      to the G allele (AG/GG) at rs4671393 (P = 0.005); while for patients of advanced 
      stage LSCC the OR was 1.73 (P = 0.002). Moreover, the OR of lymph node metastasis 
      patients at rs4671393 G alleles was 2.41 (P < 0.01); it was 1.38 (P = 0.035) in 
      patients without lymph metastasis. Patients with high incidences of the rs4671393 
      variation genotype had high plasma BCL11A levels. CONCLUSIONS: BCL11A rs11886868 
      and rs4671393 genotype variations and correspondingly high BCL11A plasma levels 
      are related to LSCC, besides, differences in plasma levels and genotype 
      distribution may be related to lymph node metastasis status and the stage of 
      LSCC.
FAU - Zhou, Jian
AU  - Zhou J
AD  - Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan 
      University, Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of otorhinolaryngology, Shanghai, China.
FAU - Yang, Yue
AU  - Yang Y
AD  - Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan 
      University, Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of otorhinolaryngology, Shanghai, China.
FAU - Zhang, Duo
AU  - Zhang D
AD  - Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan 
      University, Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of otorhinolaryngology, Shanghai, China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan 
      University, Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of otorhinolaryngology, Shanghai, China.
FAU - Tao, Lei
AU  - Tao L
AD  - Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan 
      University, Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of otorhinolaryngology, Shanghai, China.
FAU - Lu, Li-Ming
AU  - Lu LM
AD  - Shanghai Institute of Immunology, Shanghai Jiaotong University School of 
      Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20170222
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (BCL11A protein, human)
RN  - 0 (Carrier Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Repressor Proteins)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Carcinoma, Squamous Cell/blood/*genetics/pathology
MH  - Carrier Proteins/*blood/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Laryngeal Neoplasms/blood/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Nuclear Proteins/*blood/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Repressor Proteins
PMC - PMC5321498
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/02/23 06:00
MHDA- 2017/08/22 06:00
PMCR- 2017/02/22
CRDT- 2017/02/23 06:00
PHST- 2016/08/02 00:00 [received]
PHST- 2016/12/31 00:00 [accepted]
PHST- 2017/02/23 06:00 [entrez]
PHST- 2017/02/23 06:00 [pubmed]
PHST- 2017/08/22 06:00 [medline]
PHST- 2017/02/22 00:00 [pmc-release]
AID - PONE-D-16-29722 [pii]
AID - 10.1371/journal.pone.0171116 [doi]
PST - epublish
SO  - PLoS One. 2017 Feb 22;12(2):e0171116. doi: 10.1371/journal.pone.0171116. 
      eCollection 2017.