PMID- 28225860
OWN - NLM
STAT- MEDLINE
DCOM- 20180215
LR  - 20231003
IS  - 2359-4292 (Electronic)
IS  - 2359-3997 (Print)
IS  - 2359-3997 (Linking)
VI  - 61
IP  - 5
DP  - 2017 Sept-Oct
TI  - IL-6, TNF-alpha, and IL-10 levels/polymorphisms and their association with type 2 
      diabetes mellitus and obesity in Brazilian individuals.
PG  - 438-446
LID - 10.1590/2359-3997000000254 [doi]
AB  - OBJECTIVE: This study aimed to investigate the association of plasma TNF-alpha, IL-6, 
      and lL-10 levels and cytokine gene polymorphisms [TNF-alpha (-308 G-->A), IL-6 (-174 
      C-->G) and IL-10 (-1082 A-->G, -819 T-->C and -592 A-->C)] in type 2 diabetes mellitus 
      (T2DM) and obese patients. SUBJECTS AND METHODS: One hundred and two T2DM 
      patients and 62 controls were included in this study. Cytokine plasma levels were 
      measured by the Cytometric Bead Array method. Genotyping was carried out by the 
      polymerase chain reaction. RESULTS: IL-6 levels were significantly different 
      between T2DM patients and controls. Interestingly, IL-6 levels were higher in 
      T2DM patients with BMI > 30 kg/m2 compared with other patients and obese 
      controls. The genotype and allele frequencies were similar between patients and 
      controls. In the T2DM group, the SNP IL-10 -819 T/C showed a difference between 
      the cytokine level and genotypes: IL-10 level in the TT genotype was 
      significantly higher when compared to CC genotype. CONCLUSIONS: These results 
      suggest an association between IL-6 levels and obesity, and IL-10 levels and the 
      SNP -819 T/C in T2DM. Knowledge of these variants in T2DM might contribute to a 
      better understanding of the role of inflammation in the etiology and progression 
      of this disease.
FAU - Rodrigues, Kathryna Fontana
AU  - Rodrigues KF
AD  - Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais (UFMG), 
      Belo Horizonte, MG, Brasil.
FAU - Pietrani, Nathalia Teixeira
AU  - Pietrani NT
AD  - Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais (UFMG), 
      Belo Horizonte, MG, Brasil.
FAU - Bosco, Adriana Aparecida
AU  - Bosco AA
AD  - Instituto de Ensino e Pesquisa, Santa Casa de Belo Horizonte, Belo Horizonte, MG, 
      Brasil.
FAU - Campos, Fernanda Magalhaes Freire
AU  - Campos FMF
AD  - Faculdade de Farmacia, UFMG, Belo Horizonte, MG, Brasil.
FAU - Sandrim, Valeria Cristina
AU  - Sandrim VC
AD  - Instituto de Biociencias, Universidade Estadual Paulista Julio de Mesquita Filho 
      (Unesp), Botucatu, SP, Brasil.
FAU - Gomes, Karina Braga
AU  - Gomes KB
AD  - Faculdade de Farmacia, UFMG, Belo Horizonte, MG, Brasil.
LA  - eng
PT  - Journal Article
DEP - 20170216
PL  - Brazil
TA  - Arch Endocrinol Metab
JT  - Archives of endocrinology and metabolism
JID - 101652058
RN  - 0 (Biomarkers)
RN  - 0 (IL10 protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Interleukin-10/*blood/genetics
MH  - Interleukin-6/*blood/genetics
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood/genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Tumor Necrosis Factor-alpha/*blood/genetics
PMC - PMC10522244
COIS- Disclosure: no potential conflict of interest relevant to this article was 
      reported.
EDAT- 2017/02/23 06:00
MHDA- 2018/02/16 06:00
PMCR- 2017/02/01
CRDT- 2017/02/23 06:00
PHST- 2016/05/03 00:00 [received]
PHST- 2016/11/25 00:00 [accepted]
PHST- 2017/02/23 06:00 [pubmed]
PHST- 2018/02/16 06:00 [medline]
PHST- 2017/02/23 06:00 [entrez]
PHST- 2017/02/01 00:00 [pmc-release]
AID - S2359-39972017005002104 [pii]
AID - 2359-3997000000254 [pii]
AID - 10.1590/2359-3997000000254 [doi]
PST - ppublish
SO  - Arch Endocrinol Metab. 2017 Sept-Oct;61(5):438-446. doi: 
      10.1590/2359-3997000000254. Epub 2017 Feb 16.