PMID- 28225996
OWN - NLM
STAT- MEDLINE
DCOM- 20170906
LR  - 20230422
IS  - 2359-4292 (Electronic)
IS  - 2359-3997 (Print)
IS  - 2359-3997 (Linking)
VI  - 61
IP  - 2
DP  - 2017 Mar-Apr
TI  - Effect of diacerein as an add-on to metformin in patients with type 2 diabetes 
      mellitus and inadequate glycemic control.
PG  - 188-192
LID - 10.1590/2359-3997000000242 [doi]
AB  - OBJECTIVE: To evaluate the effect of diacerein as an add-on to metformin in 
      patients with type 2 diabetes mellitus (T2DM) and inadequate glycemic control. 
      MATERIALS AND METHODS: A randomized, double-blind, placebo-controlled clinical 
      trial was carried out on 12 patients with T2DM and inadequate glycemic control 
      [glycated hemoglobin A1c (A1C) >/= 7%] with metformin as monotherapy (>/= 1500 mg per 
      day) for at least the previous 90 days. Fasting and postprandial glucose were 
      measured before and after the pharmacological intervention. A1C, lipid profile, 
      creatinine and uric acid were also evaluated. After randomization, all patients 
      continued with their dose of metformin. Six subjects received placebo and the 
      other six volunteers took diacerein. Data were tested using the Wilcoxon 
      signed-rank, Mann-Whitney U and chi-square tests. The Institutional Ethics 
      Committee approved the study protocol. RESULTS: After 90 days of diacerein as an 
      add-on to metformin, there was a significant decrease in fasting glucose (196 +/- 
      79 vs. 149 +/- 70 mg/dL, p < 0.05), postprandial glucose (262 +/- 99 vs. 187 +/- 70 
      mg/dlL, p < 0.05) and A1C (8.4 +/- 2.0 vs. 6.7 +/- 1.7 %, p < 0.05). CONCLUSIONS: 
      Diacerein as an add-on to metformin in patients with T2DM improved their glycemic 
      control.
FAU - Villar, Miriam Mendez-Del
AU  - Villar MM
AD  - Institute of Experimental and Clinical Therapeutics, Physiology Department, 
      Health Science University Center, University of Guadalajara, Guadalajara, Mexico.
FAU - Martinez-Abundis, Esperanza
AU  - Martinez-Abundis E
AD  - Institute of Experimental and Clinical Therapeutics, Physiology Department, 
      Health Science University Center, University of Guadalajara, Guadalajara, Mexico.
FAU - Preciado-Marquez, Rafael O
AU  - Preciado-Marquez RO
AD  - Institute of Experimental and Clinical Therapeutics, Physiology Department, 
      Health Science University Center, University of Guadalajara, Guadalajara, Mexico.
FAU - Gonzalez-Ortiz, Manuel
AU  - Gonzalez-Ortiz M
AD  - Institute of Experimental and Clinical Therapeutics, Physiology Department, 
      Health Science University Center, University of Guadalajara, Guadalajara, Mexico.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170213
PL  - Brazil
TA  - Arch Endocrinol Metab
JT  - Archives of endocrinology and metabolism
JID - 101652058
RN  - 0 (Anthraquinones)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Placebos)
RN  - 4HU6J11EL5 (diacerein)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Adult
MH  - Anthraquinones/*administration & dosage
MH  - Anti-Inflammatory Agents/*administration & dosage
MH  - Blood Glucose/analysis/drug effects
MH  - Diabetes Mellitus, Type 2/*drug therapy/physiopathology
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Drug Therapy, Combination
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Hypoglycemic Agents/*administration & dosage
MH  - Male
MH  - Metformin/*administration & dosage
MH  - Middle Aged
MH  - Overweight/physiopathology
MH  - Placebos
MH  - Postprandial Period
MH  - Reproducibility of Results
MH  - Statistics, Nonparametric
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC10118867
COIS- Disclosure: no potential conflict of interest relevant to this article was 
      reported.
EDAT- 2017/02/23 06:00
MHDA- 2017/09/07 06:00
PMCR- 2017/01/27
CRDT- 2017/02/23 06:00
PHST- 2016/06/04 00:00 [received]
PHST- 2016/10/10 00:00 [accepted]
PHST- 2017/02/23 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
PHST- 2017/02/23 06:00 [entrez]
PHST- 2017/01/27 00:00 [pmc-release]
AID - S2359-39972017005001110 [pii]
AID - 2359-3997000000242 [pii]
AID - 10.1590/2359-3997000000242 [doi]
PST - ppublish
SO  - Arch Endocrinol Metab. 2017 Mar-Apr;61(2):188-192. doi: 
      10.1590/2359-3997000000242. Epub 2017 Feb 13.