PMID- 28226002
OWN - NLM
STAT- MEDLINE
DCOM- 20170925
LR  - 20230422
IS  - 2359-4292 (Electronic)
IS  - 2359-3997 (Print)
IS  - 2359-3997 (Linking)
VI  - 61
IP  - 3
DP  - 2017 May-Jun
TI  - Serum levels of leptin and adiponectin and clinical parameters in women with 
      fibromyalgia and overweight/obesity.
PG  - 249-256
LID - 10.1590/2359-3997000000248 [doi]
AB  - OBJECTIVES: The objectives of this study were to evaluate the serum levels of 
      adipokines in women with fibromyalgia with and without overweight/obesity, and to 
      correlate the adipokines levels with clinical parameters associated with 
      fibromyalgia and adipose tissue mass (body fat). SUBJECTS AND METHODS: The study 
      included 100 women divided into four groups: (a) fibromyalgia and 
      overweight/obesity; (b) fibromyalgia and normal weight; (c) controls and 
      overweight/obesity; and (d) controls and normal weight. Patients and controls 
      were evaluated for clinical, anthropometric, and fibromyalgia-related parameters. 
      Assessments included serum levels of leptin, adiponectin, monocyte 
      chemoattractant protein-1 (MCP-1), and C-reactive protein (CRP). Levels of 
      adipokines were further adjusted for fat mass. RESULTS: Fibromyalgia patients 
      with overweight/obesity or normal weight had no differences in clinical 
      parameters. Unadjusted leptin levels were lower in fibromyalgia patients than 
      controls, a finding that was more remarkable in fibromyalgia patients with 
      overweight/obesity. Leptin levels had no correlation with clinical parameters of 
      fibromyalgia or inflammation markers (MCP-1 and CRP), and adiponectin levels 
      showed no difference between groups. CONCLUSIONS: No correlation was observed 
      between adjusted leptin levels and clinical parameters of fibromyalgia. Patients 
      with fibromyalgia and overweight/obesity presented lower levels of leptin than 
      controls with overweight/obesity.
FAU - Paiva, Eduardo S
AU  - Paiva ES
AD  - Departamento de Medicina Interna, Universidade Federal do Parana (UFPR), 
      Curitiba, PR, Brasil.
FAU - Andretta, Aline
AU  - Andretta A
AD  - Departamento de Nutricao, UFPR, Curitiba, PR, Brasil.
FAU - Batista, Emmanuelle Dias
AU  - Batista ED
AD  - Departamento de Nutricao, UFPR, Curitiba, PR, Brasil.
FAU - Lobo, Marcia Maria Marques Teles
AU  - Lobo MMMT
AD  - Departamento de Nutricao, UFPR, Curitiba, PR, Brasil.
FAU - Miranda, Renata Costa de
AU  - Miranda RC
AD  - University of Rome Tor Vergata, Rome, Italy.
AD  - UFPR, Curitiba, PR, Brasil.
FAU - Nisihara, Renato
AU  - Nisihara R
AD  - Laboratorio de Imunopatologia, Hospital de Clinicas, UFPR, Curitiba, PR, Brasil.
FAU - Schieferdecker, Maria Eliana Madalozzo
AU  - Schieferdecker MEM
AD  - Departamento de Nutricao, UFPR, Curitiba, PR, Brasil.
FAU - Boguszewski, Cesar L
AU  - Boguszewski CL
AD  - Servico de Endocrinologia e Metabologia (SEMPR), Departamento de Medicina 
      Interna, UFPR, Curitiba, PR, Brasil.
LA  - eng
PT  - Journal Article
DEP - 20170213
PL  - Brazil
TA  - Arch Endocrinol Metab
JT  - Archives of endocrinology and metabolism
JID - 101652058
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Leptin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adult
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - C-Reactive Protein/analysis
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood
MH  - Female
MH  - Fibromyalgia/*blood/physiopathology
MH  - Humans
MH  - Leptin/*blood
MH  - Middle Aged
MH  - Overweight/*blood/physiopathology
MH  - Pain Threshold
MH  - Quality of Life
MH  - Reference Values
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
MH  - Waist Circumference
PMC - PMC10118809
COIS- Disclosure: no potential conflict of interest relevant to this article was 
      reported.
EDAT- 2017/02/23 06:00
MHDA- 2017/09/26 06:00
PMCR- 2017/01/27
CRDT- 2017/02/23 06:00
PHST- 2016/10/03 00:00 [received]
PHST- 2016/11/25 00:00 [accepted]
PHST- 2017/02/23 06:00 [pubmed]
PHST- 2017/09/26 06:00 [medline]
PHST- 2017/02/23 06:00 [entrez]
PHST- 2017/01/27 00:00 [pmc-release]
AID - S2359-39972017005001116 [pii]
AID - 2359-3997000000248 [pii]
AID - 10.1590/2359-3997000000248 [doi]
PST - ppublish
SO  - Arch Endocrinol Metab. 2017 May-Jun;61(3):249-256. doi: 
      10.1590/2359-3997000000248. Epub 2017 Feb 13.