PMID- 28226276
OWN - NLM
STAT- MEDLINE
DCOM- 20170510
LR  - 20171119
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 155
DP  - 2017 May
TI  - Different associations of albuminuria with total and cardiovascular mortality by 
      concentrations of persistent organic pollutants in the elderly.
PG  - 175-181
LID - S0013-9351(17)30126-3 [pii]
LID - 10.1016/j.envres.2017.02.006 [doi]
AB  - Epidemiologic studies have indicated that albuminuria is associated with 
      mortality from all causes and cardiovascular disease (CVD), with substantial 
      heterogeneity. We evaluated if the associations of urine albumin creatinine ratio 
      (ACR) with all-cause and CVD mortality differed depending on serum concentrations 
      of persistent organic pollutants (POPs), strong lipophilic chemical mixtures with 
      very long half-lives, which are recently linked to many degenerative diseases. 
      Study subjects were participants of the National Health and Nutrition Examination 
      Survey 1999-2004 who were 60 years or older at baseline (n=1215 and 1067 for 
      organochlorine pesticides (OCPs) and other POPs, respectively). They were 
      followed-up through 2011 (mean follow-up periods: 8.1 and 8.0 years for OCPs and 
      other POPs, respectively). The associations between the ACR and all-cause 
      mortality significantly differed by the serum levels of POPs, especially 
      organochlorine pesticides (OCPs; P(interaction)<0.01). Stratified analyses 
      indicated that the associations between ACR and all-cause mortality became 
      stronger as the serum levels of OCPs increased. Among the elderly with the 
      highest tertile of OCPs, the adjusted hazard ratios were 1.0, 1.1, and 2.9 
      (P(trend)<0.01) across the categories of ACR (<10, 10-<30, and >/=30mg/g); however, 
      ACR was not clearly related to mortality among the elderly with the lowest 
      tertile of OCPs. CVD mortality showed similar interactions, as noted for 
      all-cause mortality (P(interaction)<0.01). The different associations between 
      albuminuria and mortality by the serum OCP levels and the little association 
      among the elderly with low serum OCPs levels suggest that OCPs play an important 
      role in albuminuria-related death risk. However, these findings need to be 
      replicated in other cohort studies.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Kim, Hyun-Woo
AU  - Kim HW
AD  - Department of Family Medicine, Hana General Hospital, 1262, 2sunhwan-ro, 
      Heungdeok-gu, Cheongju 28378, Republic of Korea.
FAU - Kim, Jung-Hyun
AU  - Kim JH
AD  - Department of Family Medicine, Hana General Hospital, 1262, 2sunhwan-ro, 
      Heungdeok-gu, Cheongju 28378, Republic of Korea.
FAU - Lee, Dong-Won
AU  - Lee DW
AD  - Department of Family Medicine, Hana General Hospital, 1262, 2sunhwan-ro, 
      Heungdeok-gu, Cheongju 28378, Republic of Korea.
FAU - Cho, Sang-Hyun
AU  - Cho SH
AD  - Department of Family Medicine, Hana General Hospital, 1262, 2sunhwan-ro, 
      Heungdeok-gu, Cheongju 28378, Republic of Korea.
FAU - Jung, Ji-Hoon
AU  - Jung JH
AD  - Department of Family Medicine, Hana General Hospital, 1262, 2sunhwan-ro, 
      Heungdeok-gu, Cheongju 28378, Republic of Korea.
FAU - Kim, Ki-Su
AU  - Kim KS
AD  - Department of Preventative Medicine, School of Medicine, Kyungpook National 
      University, 680 Gukchaebosang-ro, Jung-gu, Daegu 700-842, Republic of Korea.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventative Medicine, School of Medicine, Kyungpook National 
      University, 680 Gukchaebosang-ro, Jung-gu, Daegu 700-842, Republic of Korea. 
      Electronic address: lee_dh@knu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170320
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Aged
MH  - Albuminuria/*blood/*mortality
MH  - Cardiovascular Diseases/*blood/*mortality
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Male
MH  - Middle Aged
MH  - Nutrition Surveys
OTO - NOTNLM
OT  - Albuminuria
OT  - Interaction
OT  - Mortality
OT  - Organochlorine pesticides
OT  - Persistent organic pollutants
EDAT- 2017/02/23 06:00
MHDA- 2017/05/11 06:00
CRDT- 2017/02/23 06:00
PHST- 2017/01/20 00:00 [received]
PHST- 2017/02/06 00:00 [revised]
PHST- 2017/02/08 00:00 [accepted]
PHST- 2017/02/23 06:00 [pubmed]
PHST- 2017/05/11 06:00 [medline]
PHST- 2017/02/23 06:00 [entrez]
AID - S0013-9351(17)30126-3 [pii]
AID - 10.1016/j.envres.2017.02.006 [doi]
PST - ppublish
SO  - Environ Res. 2017 May;155:175-181. doi: 10.1016/j.envres.2017.02.006. Epub 2017 
      Mar 20.