PMID- 28228423
OWN - NLM
STAT- MEDLINE
DCOM- 20170621
LR  - 20230214
IS  - 1938-3207 (Electronic)
IS  - 0002-9165 (Linking)
VI  - 105
IP  - 4
DP  - 2017 Apr
TI  - The role of gluten consumption at an early age in celiac disease development: a 
      further analysis of the prospective PreventCD cohort study.
PG  - 890-896
LID - 10.3945/ajcn.116.144352 [doi]
AB  - Background: We previously found that the introduction of small quantities of 
      gluten at 4-6 mo of age did not reduce the risk of celiac disease (CD) in a group 
      of high-risk children. However, the consumption of high amounts of gluten early 
      in life has been suggested to increase CD risk.Objective: The aim of this study 
      was to evaluate this hypothesis by using data from the previous study of the 
      PreventCD trial (www.preventcd.com).Design: Gluten intake was prospectively 
      quantified by using specific food records between 11 and 36 mo of age in 715 
      children positive for the human leukocyte antigen (HLA)-DQ2 and/or HLA-DQ8 from 5 
      European countries. According to the PreventCD protocol, infants received 100 mg 
      immunologically active gluten/d or placebo from 4 to 6 mo of age, with a stepwise 
      and fixed gluten increase until age 10 mo and unrestricted intake thereafter. The 
      primary outcome of the present study was the impact of the amount of gluten 
      consumed from age 10 mo onward on CD development.Results: Mean daily gluten 
      intakes from 10 mo onward were significantly different between countries for 
      children at all ages (P < 0.001) but not between children who developed CD and 
      those who did not within the same country (P > 0.05). The variables country, sex, 
      intervention group, and gluten consumption pattern did not show significant 
      associations with CD development risk (HRs not significant). In addition, the 
      interaction between HLA risk group and gluten consumption pattern showed no 
      significant risk on CD development, except for the DQ2.2/DQ7 haplotype (HR: 5.81; 
      95% CI: 1.18, 28.74; P = 0.031).Conclusions: Gluten consumption patterns as well 
      as the amount of gluten consumed at 11-36 mo of age do not influence CD 
      development for most related HLA genotypes in children with a genetic risk. This 
      study reports the gluten consumption pattern in children at risk of CD from 
      different European countries. This trial was registered at 
      www.controlled-trials.com as ISRCTN74582487.
CI  - (c) 2017 American Society for Nutrition.
FAU - Crespo-Escobar, Paula
AU  - Crespo-Escobar P
AUID- ORCID: 0000-0003-3180-9024
AD  - Departments of Celiac Disease and Digestive Immunopathology and 
      paula_crespo@iislafe.es.
FAU - Mearin, Maria Luisa
AU  - Mearin ML
AD  - Departments of Pediatrics and.
FAU - Hervas, David
AU  - Hervas D
AD  - Biostatistics, Medical Research Institute La Fe, Valencia, Spain.
FAU - Auricchio, Renata
AU  - Auricchio R
AD  - Department of Medical Translational Sciences and European Laboratory for the 
      Investigation of Food-Induced Diseases, University Federico II, Naples, Italy.
FAU - Castillejo, Gemma
AU  - Castillejo G
AD  - Department of Pediatrics, Hospital Universitari Sant Joan, Reus/Universitat 
      Rovira i Virgili, Tarragona, Spain.
FAU - Gyimesi, Judit
AU  - Gyimesi J
AD  - Celiac Disease Center, Heim Pal Children's Hospital, Budapest, Hungary.
FAU - Martinez-Ojinaga, Eva
AU  - Martinez-Ojinaga E
AD  - Department of Pediatric Gastroenterology and Nutrition, La Paz University 
      Hospital, Madrid, Spain.
FAU - Werkstetter, Katharina
AU  - Werkstetter K
AD  - Department of Pediatric Gastroenterology and Hepatology, Dr. von Hauner 
      Children's Hospital, Ludwig Maximilians University, Munich, Germany.
FAU - Vriezinga, Sabine Lisa
AU  - Vriezinga SL
AD  - Departments of Pediatrics and.
FAU - Korponay-Szabo, Ilma Rita
AU  - Korponay-Szabo IR
AD  - Celiac Disease Center, Heim Pal Children's Hospital, Budapest, Hungary.
FAU - Polanco, Isabel
AU  - Polanco I
AD  - Department of Pediatric Gastroenterology and Nutrition, La Paz University 
      Hospital, Madrid, Spain.
FAU - Troncone, Riccardo
AU  - Troncone R
AD  - Department of Medical Translational Sciences and European Laboratory for the 
      Investigation of Food-Induced Diseases, University Federico II, Naples, Italy.
FAU - Stoopman, Els
AU  - Stoopman E
AD  - Medical Statistics, Leiden University Medical Center, Leiden, Netherlands.
FAU - Kolacek, Sanja
AU  - Kolacek S
AD  - Referral Center for Pediatric Gastroenterology and Nutrition, University 
      Children's Hospital Zagreb, Zagreb, Croatia.
FAU - Shamir, Raanan
AU  - Shamir R
AD  - Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's 
      Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, 
      Israel.
FAU - Szajewska, Hania
AU  - Szajewska H
AD  - Department of Pediatrics, Medical University of Warsaw, Warsaw, Poland; and.
FAU - Koletzko, Sibylle
AU  - Koletzko S
AD  - Department of Pediatric Gastroenterology and Hepatology, Dr. von Hauner 
      Children's Hospital, Ludwig Maximilians University, Munich, Germany.
FAU - Ribes-Koninckx, Carmen
AU  - Ribes-Koninckx C
AD  - Pediatric Gastroenterology, University Hospital La Fe, Valencia, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170222
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ7 antigen)
RN  - 0 (HLA-DQ8 antigen)
RN  - 8002-80-0 (Glutens)
SB  - IM
MH  - Autoantibodies/blood
MH  - *Celiac Disease/etiology/genetics/immunology
MH  - *Child Nutritional Physiological Phenomena
MH  - Child, Preschool
MH  - *Diet
MH  - Diet Records
MH  - Europe
MH  - *Feeding Behavior
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Glutens/administration & dosage/immunology/*pharmacology
MH  - HLA-DQ Antigens/blood
MH  - Haplotypes
MH  - Humans
MH  - Infant
MH  - Male
MH  - Prospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - European cohort
OT  - HLA
OT  - celiac disease
OT  - children
OT  - gluten
EDAT- 2017/02/24 06:00
MHDA- 2017/06/22 06:00
CRDT- 2017/02/24 06:00
PHST- 2016/09/01 00:00 [received]
PHST- 2017/01/23 00:00 [accepted]
PHST- 2017/02/24 06:00 [pubmed]
PHST- 2017/06/22 06:00 [medline]
PHST- 2017/02/24 06:00 [entrez]
AID - S0002-9165(22)04835-3 [pii]
AID - 10.3945/ajcn.116.144352 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2017 Apr;105(4):890-896. doi: 10.3945/ajcn.116.144352. Epub 2017 
      Feb 22.