PMID- 28228841
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1750-9378 (Print)
IS  - 1750-9378 (Electronic)
IS  - 1750-9378 (Linking)
VI  - 12
DP  - 2017
TI  - An update on the management of breast cancer in Africa.
PG  - 13
LID - 10.1186/s13027-017-0124-y [doi]
LID - 13
AB  - BACKGROUND: There is limited information about the challenges of cancer 
      management and attempts at improving outcomes in Africa. Even though South and 
      North Africa are better resourceds to tackle the burden of breast cancer, similar 
      poor prognostic factors are common to all countries. The five-year overall 
      Survival rate for breast cancer patients does not exceed 60% for any low and 
      middle-income country (LMIC) in Africa. In spite of the gains achieved over the 
      past decade, certain characteristics remain the same such as limited availability 
      of breast conservation therapies, inadequate access to drugs, few oncology 
      specialists and adherence to harmful socio-cultural practices. This review on 
      managing breast cancer in Africa is authored by African oncologists who practice 
      or collaborate in Africa and with hands-on experience with the realities. 
      METHODS: A search was performed via electronic databases from 1999 to 2016. 
      (PubMed/Medline, African Journals Online) for all literature in English or 
      translated into English, covering the terms "breast cancer in Africa and 
      developing countries". One hundred ninety were deemed appropriate. RESULTS: 
      Breast tumors are diagnosed at earlier ages and later stages than in highincome 
      countries. There is a higher prevalence of triple-negative cancers. The 
      limitations of poor nursing care and surgery, inadequate access to radiotherapy, 
      poor availability of basic and modern systemic therapies translate into lower 
      survival rate. Positive strides in breast cancer management in Africa include 
      increased adaptation of treatment guidelines, improved pathology services 
      including immuno-histochemistry, expansion and upgrading of radiotherapy 
      equipment across the continent in addition to more research opportunities. 
      CONCLUSION: This review is an update of the management of breast cancer in 
      Africa, taking a look at the epidemiology, pathology, management resources, 
      outcomes, research and limitations in Africa from the perspective of oncologists 
      with local experience.
FAU - Vanderpuye, V
AU  - Vanderpuye V
AUID- ORCID: 0000-0003-3656-6965
AD  - National center for Radiotherapy and Nuclear Medicine, Korle-Bu Teaching 
      Hospital, Accra, Ghana. ISNI: 0000 0004 0546 3805. GRID: grid.415489.5
FAU - Grover, S
AU  - Grover S
AD  - Hospital of University of Pennsylvania, Department of Radiation Oncology, 
      (Botswana-UPENN program), 3400 Civic Center Blvd., Philadelphia, PA 19104 USA. 
      ISNI: 0000 0004 0435 0884. GRID: grid.411115.1
FAU - Hammad, N
AU  - Hammad N
AD  - Cancer Centre of Southeastern Ontario, Burr 2, Kingston General Hospital, 25 King 
      Street W, Kingston, ON K7L 5P9 Canada. ISNI: 0000 0004 0633 727X. GRID: 
      grid.415354.2
FAU - PoojaPrabhakar
AU  - PoojaPrabhakar
AD  - University of Texas Southwestern Medical Center, Dallas, TX USA. ISNI: 0000 0000 
      9482 7121. GRID: grid.267313.2
FAU - Simonds, H
AU  - Simonds H
AD  - Division of Radiation Oncology, Tygerberg Hospital/University of Stellenbosch, 
      Tygerberg, South Africa.
FAU - Olopade, F
AU  - Olopade F
AD  - The University of Chicago, 5841 S Maryland Avenue, MC 2115, Chicago, IL 60637 
      USA. ISNI: 0000 0004 1936 7822. GRID: grid.170205.1
FAU - Stefan, D C
AU  - Stefan DC
AD  - Walter Sisulu University Nelson Mandela Dr, Nelson Mandela Drive, Mthatha, 5100 
      Eastern Cape South Africa. ISNI: 0000 0001 0447 7939. GRID: grid.412870.8
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170214
PL  - England
TA  - Infect Agent Cancer
JT  - Infectious agents and cancer
JID - 101276559
PMC - PMC5307840
OTO - NOTNLM
OT  - Breast cancer
OT  - Chemotherapy
OT  - Hormonal therapy
OT  - Radiotherapy
OT  - Survival
OT  - Targeted therapies
EDAT- 2017/02/24 06:00
MHDA- 2017/02/24 06:01
PMCR- 2017/02/14
CRDT- 2017/02/24 06:00
PHST- 2016/10/17 00:00 [received]
PHST- 2017/02/03 00:00 [accepted]
PHST- 2017/02/24 06:00 [entrez]
PHST- 2017/02/24 06:00 [pubmed]
PHST- 2017/02/24 06:01 [medline]
PHST- 2017/02/14 00:00 [pmc-release]
AID - 124 [pii]
AID - 10.1186/s13027-017-0124-y [doi]
PST - epublish
SO  - Infect Agent Cancer. 2017 Feb 14;12:13. doi: 10.1186/s13027-017-0124-y. 
      eCollection 2017.