PMID- 28229219
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20231112
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Print)
IS  - 1861-0684 (Linking)
VI  - 106
IP  - 6
DP  - 2017 Jun
TI  - Prevalence and clinical impact of iron deficiency and anaemia among outpatients 
      with chronic heart failure: The PrEP Registry.
PG  - 436-443
LID - 10.1007/s00392-016-1073-y [doi]
AB  - BACKGROUND: Iron deficiency (ID) and anaemia are common in heart failure (HF). 
      The prospective, observational PReP registry (Pravalenz des Eisenmangels bei 
      Patienten mit Herzinsuffizienz) studied prevalence and clinical impact of ID and 
      anaemia in HF outpatients attending cardiology practices in Germany. METHODS AND 
      RESULTS: A total of 42 practices enrolled consecutive patients with chronic HF 
      [left ventricular ejection fraction (LVEF) </=45%]. ID was defined as serum 
      ferritin <100 microg/l, or serum ferritin >/=100 microg/l/<300 microg/l plus transferrin 
      saturation <20%, and anaemia as haemoglobin <13 g/dl (12 g/dl) in men (women). 
      Exercise capacity was assessed using spiroergometry (69.4%) or 6-min walk test 
      (30.4%). Amongst 1198 PReP-participants [69.0  +/- 10.6 years, 25.3% female, New 
      York Heart Association (NYHA) class 2.4  +/- 0.5, LVEF 35.3 +/- 7.2%], ID was found 
      in 42.5% (previously unknown in all), and anaemia in 18.9% (previously known in 
      4.8%). ID was associated with female gender, lower body weight and haemoglobin, 
      higher NYHA class and natriuretic peptide (NP) levels (all p < 0.05). ID was also 
      more common in anaemic than non-anaemic patients (p < 0.0001), and 9.8% of 
      PrEP-participants had both, ID and anaemia. On spiroergometry, ID independently 
      predicted maximum exercise capacity even after multivariable adjustment, 
      including anaemia (p = 0.0004). In all PrEP-participants, ID predicted reduced 
      physical performance (adjusted for age, gender, anaemia, serum creatinine, 
      C-reactive protein, LVEF, and NP level). CONCLUSIONS: Despite high prevalence, ID 
      was previously unknown in all PrEP-participants, and anaemia was often 
      unappreciated. Given the clinical relevance, treatability, and independent 
      association with reduced physical performance, ID should be considered more in 
      real-world ambulatory healthcare settings and ID-screening be advocated to 
      cardiologists in such populations.
FAU - von Haehling, Stephan
AU  - von Haehling S
AD  - Department of Cardiology and Pneumology, University of Gottingen Medical School, 
      Robert-Koch-Strasse 40, 37075, Gottingen, Germany. stephan.von.haehling@web.de.
FAU - Gremmler, Uwe
AU  - Gremmler U
AD  - MVZ Ambulantes kardiologisches Zentrum, Peine, Germany.
FAU - Krumm, Michael
AU  - Krumm M
AD  - MVZ Ambulantes kardiologisches Zentrum, Peine, Germany.
FAU - Mibach, Frank
AU  - Mibach F
AD  - Kardiologische Praxis, Gesundheitszentrum Klosterforst, Itzehoe, Germany.
FAU - Schon, Norbert
AU  - Schon N
AD  - Kardiologisch-angiologische Praxis, Muhldorf am Inn, Germany.
FAU - Taggeselle, Jens
AU  - Taggeselle J
AD  - Kardiologische Praxis, Markkleeberg, Germany.
FAU - Dahm, Johannes B
AU  - Dahm JB
AD  - Praxis und Klinik fur Kardiologie und Angiologie, Herz- und Gefasszentrum, 
      Krankenhaus Neu-Bethlehem, Gottingen, Germany.
FAU - Angermann, Christiane E
AU  - Angermann CE
AD  - Department of Medicine I, Comprehensive Heart Failure Center, University Hospital 
      Wurzburg, University of Wurzburg, Wurzburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170222
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
RN  - 0 (Hemoglobins)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anemia/*epidemiology
MH  - Body Weight
MH  - C-Reactive Protein/metabolism
MH  - Chronic Disease
MH  - Exercise Tolerance/physiology
MH  - Female
MH  - Germany
MH  - Heart Failure/*physiopathology
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - *Iron Deficiencies
MH  - Male
MH  - Middle Aged
MH  - Outpatients
MH  - Prevalence
MH  - Prospective Studies
MH  - Registries
MH  - Risk Factors
MH  - Sex Factors
MH  - Ventricular Function, Left/physiology
PMC - PMC5442200
OTO - NOTNLM
OT  - Anaemia
OT  - Exercise capacity
OT  - Heart failure
OT  - Iron deficiency
OT  - Prevalence
COIS- FUNDING: This work was supported by Vifor Pharma. CONFLICT OF INTEREST: SvH has 
      received consulting honoraria from Vifor Pharma and lecture fees from Amgen. C.E. 
      Angermann acknowledges grant and other support, speaker honoraria, and 
      consultancy fees from Vifor Pharma. All other authors have no conflicts of 
      interest relevant to this manuscript to disclose.
EDAT- 2017/02/24 06:00
MHDA- 2018/03/10 06:00
PMCR- 2017/02/22
CRDT- 2017/02/24 06:00
PHST- 2016/09/15 00:00 [received]
PHST- 2016/12/23 00:00 [accepted]
PHST- 2017/02/24 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
PHST- 2017/02/24 06:00 [entrez]
PHST- 2017/02/22 00:00 [pmc-release]
AID - 10.1007/s00392-016-1073-y [pii]
AID - 1073 [pii]
AID - 10.1007/s00392-016-1073-y [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2017 Jun;106(6):436-443. doi: 10.1007/s00392-016-1073-y. Epub 
      2017 Feb 22.