PMID- 28229321
OWN - NLM
STAT- MEDLINE
DCOM- 20170428
LR  - 20181202
IS  - 1129-2377 (Electronic)
IS  - 1129-2369 (Print)
IS  - 1129-2369 (Linking)
VI  - 18
IP  - 1
DP  - 2017 Dec
TI  - Cerebral endothelial dysfunction in reversible cerebral vasoconstriction 
      syndrome: a case-control study.
PG  - 29
LID - 10.1186/s10194-017-0738-x [doi]
LID - 29
AB  - BACKGROUND: The aim of this study is to investigate cerebral endothelial 
      dysfunction in patients with reversible cerebral vasoconstriction syndrome 
      (RCVS). METHODS: We prospectively recruited patients with RCVS, age-matched 
      controls with episodic migraine, and age-matched healthy controls at Samsung 
      Medical Center from Apr 2015 to Jul 2016. All participants underwent transcranial 
      Doppler evaluation, with a breath-holding maneuver, for the evaluation of 
      bilateral middle cerebral arteries (MCAs), posterior cerebral arteries (PCAs), 
      and the basilar artery (BA). The breath-holding index (BHI) was used to measure 
      cerebral endothelium-dependent vasodilation. Follow-up BHIs were recorded in 
      selected patients with RCVS after 3 months. RESULTS: A total of 84 subjects were 
      recruited for this study (n = 28 in each group of RCVS, episodic migraine, and 
      healthy control; mean age, 49.8 years). The RCVS group showed lower BHIs in all 
      basal arteries, in comparison to healthy controls (p < 0.001, 0.009 for bilateral 
      MCAs, p < 0.001 and 0.028 for bilateral PCAs, and p = 0.060 for the BA). Compared 
      to migraineurs, RCVS patients had lower BHIs only in the anterior circulation 
      (p = 0.002 and 0.038 for bilateral MCAs; p = 0.069 and 0.247 for bilateral PCAs; 
      p = 0.120 for the BA). Of the 10 patients who had follow-up BHIs at 3 months, 7 
      showed complete normalization, while three did not. CONCLUSIONS: Cerebral 
      endothelial function is impaired in a widespread distribution in RCVS. Its role 
      in the pathogenesis and clinical outcome of RCVS should be determined in further 
      studies.
FAU - Choi, Hyun Ah
AU  - Choi HA
AD  - Samsung Medical Center, Sungkyunkwan University School of Medicine, Neurology, 81 
      Irwon-Ro, Gangnam-Gu, Seoul, 06531, South Korea.
FAU - Lee, Mi Ji
AU  - Lee MJ
AD  - Samsung Medical Center, Sungkyunkwan University School of Medicine, Neurology, 81 
      Irwon-Ro, Gangnam-Gu, Seoul, 06531, South Korea.
FAU - Chung, Chin-Sang
AU  - Chung CS
AD  - Samsung Medical Center, Sungkyunkwan University School of Medicine, Neurology, 81 
      Irwon-Ro, Gangnam-Gu, Seoul, 06531, South Korea. cspaul@naver.com.
LA  - eng
PT  - Journal Article
DEP - 20170223
PL  - England
TA  - J Headache Pain
JT  - The journal of headache and pain
JID - 100940562
SB  - IM
MH  - Adult
MH  - Breath Holding
MH  - Case-Control Studies
MH  - Cerebral Arterial Diseases/*diagnostic imaging/*physiopathology
MH  - Endothelium, Vascular/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/*diagnostic imaging/*physiopathology
MH  - Prospective Studies
MH  - Syndrome
MH  - Ultrasonography, Doppler, Transcranial
MH  - Vasoconstriction/*physiology
PMC - PMC5321640
OTO - NOTNLM
OT  - Breath holding index
OT  - Cerebral vasomotor reactivity
OT  - Endothelial dysfunction
OT  - Pathophysiology
OT  - Reversible cerebral vasoconstriction syndrome
EDAT- 2017/02/24 06:00
MHDA- 2017/04/30 06:00
PMCR- 2017/02/23
CRDT- 2017/02/24 06:00
PHST- 2016/12/13 00:00 [received]
PHST- 2017/02/15 00:00 [accepted]
PHST- 2017/02/24 06:00 [entrez]
PHST- 2017/02/24 06:00 [pubmed]
PHST- 2017/04/30 06:00 [medline]
PHST- 2017/02/23 00:00 [pmc-release]
AID - 10.1186/s10194-017-0738-x [pii]
AID - 738 [pii]
AID - 10.1186/s10194-017-0738-x [doi]
PST - ppublish
SO  - J Headache Pain. 2017 Dec;18(1):29. doi: 10.1186/s10194-017-0738-x. Epub 2017 Feb 
      23.