PMID- 28230104
OWN - NLM
STAT- MEDLINE
DCOM- 20181113
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
DP  - 2017 Feb 23
TI  - Long-term Impact of Temporal Sequence from Childhood Obesity to Hyperinsulinemia 
      on Adult Metabolic Syndrome and Diabetes: The Bogalusa Heart Study.
PG  - 43422
LID - 10.1038/srep43422 [doi]
LID - 43422
AB  - This study aims to delineate the temporal relations between body mass index (BMI) 
      and insulin in childhood and their impact on adult metabolic syndrome (MetS) and 
      type 2 diabetes mellitus (T2DM).The longitudinal cohort consisted of 609 whites 
      and 339 blacks who had BMI and fasting insulin measured twice in childhood (mean 
      age = 10.5 years at baseline and 15.9 years at follow-up). Incident MetS and T2DM 
      were identified in adulthood (mean age = 30.5 years). Cross-lagged panel and 
      mediation analysis models were used. After adjusting for age, race, gender, and 
      follow-up years, the cross-lagged path coefficient of BMI --> insulin (beta = 0.326, 
      p < 0.001) was significantly greater than that of insulin --> BMI (beta = -0.023, 
      p = 0.207) in childhood, with p < 0.001 for the difference in betas. The path 
      coefficient for BMI --> insulin was significantly greater in MetS than in non-MetS 
      groups (0.510 vs 0.190, p < 0.001), and greater in hyperglycemia than in 
      normoglycemia groups (0.503 vs 0.285, p = 0.026). The mediation effect of 
      childhood insulin on the BMI-MetS and BMI-hyperglycemia associations was 
      estimated at 19.2% (p < 0.001) and 18.3% (p < 0.001), respectively. These 
      findings provide evidence that higher BMI levels precede hyperinsulinemia during 
      childhood, and this one-directional relation plays a significant role in the 
      development of MetS and T2DM in adult life.
FAU - Zhang, Tao
AU  - Zhang T
AD  - Department of Biostatistics, School of Public Health, Shandong University, Jinan, 
      China.
AD  - Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane 
      University, New Orleans, LA, USA.
FAU - Zhang, Huijie
AU  - Zhang H
AD  - Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane 
      University, New Orleans, LA, USA.
AD  - Department of Endocrinology and Metabolism, the First Hospital of Xiamen, Xiamen 
      University, Xiamen, China.
FAU - Li, Ying
AU  - Li Y
AD  - Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane 
      University, New Orleans, LA, USA.
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical 
      University, Harbin, China.
FAU - Li, Shengxu
AU  - Li S
AD  - Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane 
      University, New Orleans, LA, USA.
FAU - Fernandez, Camilo
AU  - Fernandez C
AD  - Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane 
      University, New Orleans, LA, USA.
FAU - Bazzano, Lydia
AU  - Bazzano L
AD  - Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane 
      University, New Orleans, LA, USA.
FAU - He, Jiang
AU  - He J
AD  - Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane 
      University, New Orleans, LA, USA.
FAU - Xue, Fuzhong
AU  - Xue F
AD  - Department of Biostatistics, School of Public Health, Shandong University, Jinan, 
      China.
FAU - Chen, Wei
AU  - Chen W
AD  - Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane 
      University, New Orleans, LA, USA.
LA  - eng
GR  - R01 AG016592/AG/NIA NIH HHS/United States
GR  - R01 AG041200/AG/NIA NIH HHS/United States
GR  - R01 ES021724/ES/NIEHS NIH HHS/United States
GR  - RF1 AG041200/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170223
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Analysis of Variance
MH  - Black People
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - Child
MH  - Diabetes Mellitus, Type 2/blood/*diagnosis/ethnology/pathology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Hyperinsulinism/blood/*diagnosis/ethnology/pathology
MH  - Insulin/*blood
MH  - *Insulin Resistance
MH  - Longitudinal Studies
MH  - Male
MH  - Metabolic Syndrome/blood/*diagnosis/ethnology/pathology
MH  - Middle Aged
MH  - Pediatric Obesity/blood/*diagnosis/ethnology/pathology
MH  - White People
PMC - PMC5322533
COIS- The authors declare no competing financial interests.
EDAT- 2017/02/24 06:00
MHDA- 2018/11/14 06:00
PMCR- 2017/02/23
CRDT- 2017/02/24 06:00
PHST- 2016/10/03 00:00 [received]
PHST- 2017/01/24 00:00 [accepted]
PHST- 2017/02/24 06:00 [entrez]
PHST- 2017/02/24 06:00 [pubmed]
PHST- 2018/11/14 06:00 [medline]
PHST- 2017/02/23 00:00 [pmc-release]
AID - srep43422 [pii]
AID - 10.1038/srep43422 [doi]
PST - epublish
SO  - Sci Rep. 2017 Feb 23;7:43422. doi: 10.1038/srep43422.