PMID- 28230291
OWN - NLM
STAT- MEDLINE
DCOM- 20171226
LR  - 20211204
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 118
IP  - 9
DP  - 2017 Sep
TI  - Therapeutic Potentials of BDNF/TrkB in Breast Cancer; Current Status and 
      Perspectives.
PG  - 2502-2515
LID - 10.1002/jcb.25943 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a potent neurotrophic factor that has 
      been shown to stimulate breast cancer cell growth and metastasis via tyrosine 
      kinase receptors TrkA, TrkB, and the p75(NTR) death receptor. The aberrant 
      activation of BDNF/TrkB pathways can modulate several signaling pathways, 
      including Akt/PI3K, Jak/STAT, NF-kB, UPAR/UPA, Wnt/beta-catenin, and VEGF pathways 
      as well as the ER receptor. Several microRNAs have been identified that are 
      involved in the modulation of BDNF/TrkB pathways. These include miR-206, miR-204, 
      MiR-200a/c, MiR-210, MiR-134, and MiR-191; and these may be of value as 
      prognostic and predictive biomarkers for detecting patients at high risk of 
      developing breast cancer. It has been also been demonstrated that a high 
      expression of genes involved in the BDNF pathway in breast cancer is associated 
      with poor clinical outcome and reduced survival of patients. Several approaches 
      have been developed for targeting this pathway, for example TKr inhibitors 
      (AZD6918, CEP-701) and RNA interference. The aim of the current review was to 
      provide an overview of the role of BDNF/TrkB pathways in the pathogenesis of 
      breast cancer and its value as a potential therapeutic target. J. Cell. Biochem. 
      118: 2502-2515, 2017. (c) 2017 Wiley Periodicals, Inc.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Tajbakhsh, Amir
AU  - Tajbakhsh A
AD  - Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
AD  - Student Research Committee, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Mokhtari-Zaer, Amin
AU  - Mokhtari-Zaer A
AD  - Student Research Committee, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
AD  - Neurogenic Inflammation Research Centre and Department of Physiology, Faculty of 
      Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Rezaee, Mehdi
AU  - Rezaee M
AD  - Student Research Committee, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
AD  - Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
FAU - Afzaljavan, Fahimeh
AU  - Afzaljavan F
AD  - Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
AD  - Student Research Committee, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Rivandi, Mehdi
AU  - Rivandi M
AD  - Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
AD  - Student Research Committee, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Hassanian, Seyed Mahdi
AU  - Hassanian SM
AUID- ORCID: 0000-0002-5247-4043
AD  - Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
AD  - Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
FAU - Ferns, Gordon A
AU  - Ferns GA
AD  - Brighton & Sussex Medical School, Division of Medical Education, Falmer, 
      Brighton, UK.
FAU - Pasdar, Alireza
AU  - Pasdar A
AD  - Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
AD  - Division of Applied Medicine, Medical School, University of Aberdeen, 
      Foresterhill, Aberdeen, UK.
AD  - Medical Genetics Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Avan, Amir
AU  - Avan A
AUID- ORCID: 0000-0002-4968-0962
AD  - Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170515
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Furans)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (MicroRNAs)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 0 (RNA, Neoplasm)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - DO989GC5D1 (lestaurtinib)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (tropomyosin-related kinase-B, human)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - *Breast Neoplasms/metabolism/pathology/therapy
MH  - Carbazoles/therapeutic use
MH  - Female
MH  - Furans
MH  - Humans
MH  - Membrane Glycoproteins/*antagonists & inhibitors/*metabolism
MH  - MicroRNAs/metabolism
MH  - Neoplasm Proteins/*metabolism
MH  - Protein Kinase Inhibitors/*therapeutic use
MH  - *RNA Interference
MH  - RNA, Neoplasm/metabolism
MH  - Receptor, trkB/*antagonists & inhibitors/*metabolism
MH  - *Wnt Signaling Pathway
OTO - NOTNLM
OT  - BRAIN-DERIVED NEUROTROPHIC FACTOR
OT  - BREAST CANCER
OT  - EPIGENETICS
OT  - PHARMACOLOGICAL MODULATORS
OT  - RISK FACTOR
EDAT- 2017/02/24 06:00
MHDA- 2017/12/27 06:00
CRDT- 2017/02/24 06:00
PHST- 2017/02/21 00:00 [received]
PHST- 2017/02/21 00:00 [accepted]
PHST- 2017/02/24 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
PHST- 2017/02/24 06:00 [entrez]
AID - 10.1002/jcb.25943 [doi]
PST - ppublish
SO  - J Cell Biochem. 2017 Sep;118(9):2502-2515. doi: 10.1002/jcb.25943. Epub 2017 May 
      15.