PMID- 28232897
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2169-0693 (Print)
IS  - 2169-0707 (Electronic)
IS  - 2169-0707 (Linking)
VI  - 4
IP  - 1
DP  - 2016
TI  - Intrinsic disorder in biomarkers of insulin resistance, hypoadiponectinemia, and 
      endothelial dysfunction among the type 2 diabetic patients.
PG  - e1171278
LID - 10.1080/21690707.2016.1171278 [doi]
LID - e1171278
AB  - Type 2 diabetes mellitus (T2DM) is a chronic and progressive disease that is 
      strongly associated with various complications including cardiovascular diseases 
      and related mortality. The present study aimed to analyze the abundance and 
      functionality of intrinsically disordered regions in several biomarkers of 
      insulin resistance, adiponectin, and endothelial dysfunction found in the T2DM 
      patients. In fact, in comparison to controls, obese T2DM patients are known to 
      have significantly higher levels of inter-cellular adhesion molecule (iCAM-1), 
      vascular cell adhesion molecule (vCAM-1), and E-selectin, whereas their 
      adiponectin levels are relatively low. Bioinformatics analysis revealed that 
      these selected biomarkers (iCAM-1, vCAM-1, E-selectin, and adiponectin) are 
      characterized by the noticeable levels of intrinsic disorder propensity and high 
      binding promiscuity, which are important features expected for proteins serving 
      as biomarkers. Within the limit of studied groups, there is an association 
      between insulin resistance and both hypoadiponectinemia and endothelial 
      dysfunction.
FAU - Al-Jiffri, Osama H
AU  - Al-Jiffri OH
AD  - Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, 
      King Abdulaziz University , Jeddah, Saudi Arabia.
FAU - Al-Sharif, Fadwa M
AU  - Al-Sharif FM
AD  - Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, 
      King Abdulaziz University , Jeddah, Saudi Arabia.
FAU - Al-Jiffri, Essam H
AU  - Al-Jiffri EH
AD  - Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, 
      King Abdulaziz University , Jeddah, Saudi Arabia.
FAU - Uversky, Vladimir N
AU  - Uversky VN
AD  - Faculty of Science, Department of Biological Science, King Abdulaziz University, 
      Jeddah, Saudi Arabia; Department of Molecular Medicine and USF Health Byrd 
      Alzheimer Research Institute, Morsani College of Medicine, University of South 
      Florida, Tampa, FL, USA; Laboratory of Structural Dynamics, Stability and Folding 
      of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 
      Russia.
LA  - eng
PT  - Journal Article
DEP - 20160511
PL  - United States
TA  - Intrinsically Disord Proteins
JT  - Intrinsically disordered proteins
JID - 101615681
PMC - PMC5314883
OTO - NOTNLM
OT  - E-selectin
OT  - Type 2 diabetes
OT  - adiponectin
OT  - iCAM-1
OT  - insulin resistance
OT  - intrinsically disordered protein
OT  - vCAM-1
EDAT- 2017/02/25 06:00
MHDA- 2017/02/25 06:01
PMCR- 2017/05/11
CRDT- 2017/02/25 06:00
PHST- 2015/12/02 00:00 [received]
PHST- 2016/03/15 00:00 [revised]
PHST- 2016/03/17 00:00 [accepted]
PHST- 2017/02/25 06:00 [entrez]
PHST- 2017/02/25 06:00 [pubmed]
PHST- 2017/02/25 06:01 [medline]
PHST- 2017/05/11 00:00 [pmc-release]
AID - 1171278 [pii]
AID - 10.1080/21690707.2016.1171278 [doi]
PST - epublish
SO  - Intrinsically Disord Proteins. 2016 May 11;4(1):e1171278. doi: 
      10.1080/21690707.2016.1171278. eCollection 2016.