PMID- 28233263
OWN - NLM
STAT- MEDLINE
DCOM- 20180215
LR  - 20181202
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 27
IP  - 8
DP  - 2017 Aug
TI  - Effects of Duodenal-Jejunal Exclusion and New Bilio-Pancreatic Diversion on Blood 
      Glucose in Rats with Type 2 Diabetes Mellitus.
PG  - 2067-2072
LID - 10.1007/s11695-017-2599-4 [doi]
AB  - OBJECTIVE: The current study aimed to investigate the effects of duodenal-jejunal 
      bypass (DJB), new bilio-pancreatic diversion (NBPD), and duodenal-jejunal 
      exclusion (DJE) on blood glucose in rats with type 2 diabetes mellitus (T2DM). 
      METHODS: Male Sprague Dawley rats were fed with high glucose, high fat food, and 
      intraperitoneally injected with streptozotocin to establish a T2DM animal model. 
      T2DM rats were randomly assigned into 4 groups: a sham group (n = 8), DJB group 
      (n = 9), NBPD group (n = 10), and DJE group (n = 10). Body weight, 2-h 
      postprandial glucose, oral glucose tolerance, fasting serum bile acid, 2-h 
      postprandial serum bile acid, fasting insulin, 2-h postprandial insulin (INS), 
      fasting glucagon-like peptide-1 (GLP-1), and 2-h postprandial GLP-1 were measured 
      before and after surgery. RESULTS: Six weeks after surgery, the 2-h postprandial 
      glucose in the DJB (16.1 +/- 6.7 mmol/L) and NBPD (19.5 +/- 5.7 mmol/L) groups 
      decreased significantly compared to the sham group (25.8 +/- 4.9 mmol/L) 
      (P < 0.05). There was no significant difference between the DJE 
      (25.0 +/- 5.0 mmol/L) and sham groups (P > 0.05). Four weeks after surgery, fasting 
      serum bile acid in the DJB group (60.6 +/- 11.4 mumol/L) and NBPD group 
      (54.4 +/- 7.64 mumol/L) was significantly higher than that in the sham group 
      (34.3 +/- 6.98 mumol/L; P < 0.05). However, fasting GLP-1, 2-h postprandial GLP-1, 
      and insulin remained unchanged at different time points after surgery (P > 0.05). 
      Body weight remained stable after surgery in all 4 groups (P > 0.05). CONCLUSION: 
      NBPD plays a major role in the therapy of T2DM with DJB. NBPD may significantly 
      increase fasting serum bile acid in T2DM rats, an action that may be one of the 
      mechanisms underlying the therapeutic effects of DJB on T2DM.
FAU - Weng, Shan Geng
AU  - Weng SG
AD  - Hepatopancreatobiliary Surgery Department, the First Affiliated Hospital of 
      Fujian Medical University, No 20 Chazhong Road, Fuzhou City, Fujian, People's 
      Republic of China. shangeng@sina.com.
FAU - Zhang, Bin
AU  - Zhang B
AD  - Hepatopancreatobiliary Surgery Department, the First Affiliated Hospital of 
      Fujian Medical University, No 20 Chazhong Road, Fuzhou City, Fujian, People's 
      Republic of China.
FAU - Wang, Xiaojian
AU  - Wang X
AD  - Hepatopancreatobiliary Surgery Department, the First Affiliated Hospital of 
      Fujian Medical University, No 20 Chazhong Road, Fuzhou City, Fujian, People's 
      Republic of China.
FAU - Chen, Hao
AU  - Chen H
AD  - Hepatopancreatobiliary Surgery Department, the First Affiliated Hospital of 
      Fujian Medical University, No 20 Chazhong Road, Fuzhou City, Fujian, People's 
      Republic of China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 5W494URQ81 (Streptozocin)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Animals
MH  - Biliopancreatic Diversion/*methods
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Experimental/metabolism/pathology/*surgery
MH  - Diabetes Mellitus, Type 2/metabolism/pathology/*surgery
MH  - Duodenum/*surgery
MH  - Gastric Bypass/methods
MH  - Glucagon-Like Peptide 1/blood
MH  - Glucose Tolerance Test
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Jejunum/*surgery
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Streptozocin
OTO - NOTNLM
OT  - Bile acid
OT  - Duodenal-jejunal exclusion
OT  - Glucagon-like peptide-1
OT  - New bilio-pancreatic diversion
EDAT- 2017/02/25 06:00
MHDA- 2018/02/16 06:00
CRDT- 2017/02/25 06:00
PHST- 2017/02/25 06:00 [pubmed]
PHST- 2018/02/16 06:00 [medline]
PHST- 2017/02/25 06:00 [entrez]
AID - 10.1007/s11695-017-2599-4 [pii]
AID - 10.1007/s11695-017-2599-4 [doi]
PST - ppublish
SO  - Obes Surg. 2017 Aug;27(8):2067-2072. doi: 10.1007/s11695-017-2599-4.