PMID- 28233393
OWN - NLM
STAT- MEDLINE
DCOM- 20180613
LR  - 20210109
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 32
IP  - 1
DP  - 2018 Jan
TI  - Association of tumor necrosis factor-alpha -308 G/A gene polymorphism with coronary 
      artery diseases: An evidence-based study.
LID - 10.1002/jcla.22153 [doi]
LID - e22153
AB  - BACKGROUND: Coronary artery disease (CAD) is the leading cause of death worldwide 
      and remains a major health problem, providing the rationale for identification of 
      molecular markers for detection of individuals at high risk of developing CAD. 
      Tumor necrosis factor-alpha (TNF-alpha) plays a crucial role in the pathogenesis of CAD. 
      We have therefore explored the association of TNF-alpha 308 (G/A) gene polymorphism 
      in 903 individuals with/without CAD. METHODS: TNF-alpha 308 gene polymorphism was 
      analyzed in 903 subjects of whom 222 were healthy controls. Among the 681 
      patients who were investigated angiographically, 468 had >==50% stenosis and 213 
      patients had <50% stenosis. Biochemical profiles (eg, triglycerides, high-density 
      lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting blood 
      glucose, and CRP) were evaluated. Associations between TNF-alpha genotypes with 
      biochemical and anthropometric characteristics were determined. RESULTS: The 
      frequencies of TNF-alpha-AA or AG genotypes were significantly lower in patients 
      classified as CAD patients with >/= or <50% obstruction in at least one coronary 
      artery, compared to the control group. We observed that CAD patients with >/=50% 
      stenosis and with AA genotype were associated with higher risk of CAD with OR of 
      3.56 (95%CI: 1.02-12.41; P=.046) using multivariate analysis. Moreover, we found 
      that TNF-alpha-308-AA genotype was associated with blood pressure and CRP level in 
      CAD patients, compared to the wild type-genotype. CONCLUSION: Our data showed an 
      association of TNF-alpha-308G/A polymorphism with CAD patients with >/=50% obstruction, 
      supporting the need for further investigations on the role of TNF-alpha-308G/A 
      polymorphism with hypertension.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Kazemi, Elaheh
AU  - Kazemi E
AD  - Department of Biochemistry, International Campus of Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
AD  - Molecular Medicine Group, Department of Modern Sciences and Technologies, School 
      of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Jamialahmadi, Khadijeh
AU  - Jamialahmadi K
AD  - Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
AD  - Department of Medical Biotechnology, School of Medicine, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
FAU - Avan, Amir
AU  - Avan A
AD  - Metabolic syndrome Research center, School of Medicine, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
FAU - Mirhafez, Seyed Reza
AU  - Mirhafez SR
AD  - Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, 
      Neyshabur, Iran.
FAU - Mohiti, Javad
AU  - Mohiti J
AD  - Department of Biochemistry, International Campus of Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
FAU - Pirhoushiaran, Maryam
AU  - Pirhoushiaran M
AD  - Molecular Medicine Group, Department of Modern Sciences and Technologies, School 
      of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Hosseini, Nedasadat
AU  - Hosseini N
AD  - Molecular Medicine Group, Department of Modern Sciences and Technologies, School 
      of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Mohammadi, Akram
AU  - Mohammadi A
AD  - Molecular Medicine Group, Department of Modern Sciences and Technologies, School 
      of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Ferns, Gordon A
AU  - Ferns GA
AD  - Division of Medical Education, Brighton & Sussex Medical School, Brighton, 
      Sussex, UK.
FAU - Pasdar, Alireza
AU  - Pasdar A
AD  - Molecular Medicine Group, Department of Modern Sciences and Technologies, School 
      of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AD  - Division of Applied Medicine, Medical School, University of Aberdeen, Aberdeen, 
      UK.
FAU - Ghayour-Mobarhan, Majid
AU  - Ghayour-Mobarhan M
AUID- ORCID: 0000-0002-4968-0962
AD  - Metabolic syndrome Research center, School of Medicine, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170223
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Coronary Artery Disease/*epidemiology/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
PMC - PMC6817255
OTO - NOTNLM
OT  - coronary artery disease
OT  - genotype
OT  - tumor necrosis factor-alpha
EDAT- 2017/02/25 06:00
MHDA- 2018/06/14 06:00
PMCR- 2017/02/23
CRDT- 2017/02/25 06:00
PHST- 2016/09/13 00:00 [received]
PHST- 2016/12/29 00:00 [accepted]
PHST- 2017/02/25 06:00 [pubmed]
PHST- 2018/06/14 06:00 [medline]
PHST- 2017/02/25 06:00 [entrez]
PHST- 2017/02/23 00:00 [pmc-release]
AID - JCLA22153 [pii]
AID - 10.1002/jcla.22153 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2018 Jan;32(1):e22153. doi: 10.1002/jcla.22153. Epub 2017 Feb 
      23.