PMID- 28233888
OWN - NLM
STAT- MEDLINE
DCOM- 20170329
LR  - 20181202
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Linking)
VI  - 27
IP  - 2
DP  - 2017 Mar 10
TI  - Optical coherence tomography in Best vitelliform macular dystrophy.
PG  - 201-204
LID - 10.5301/ejo.5000878 [doi]
AB  - PURPOSE: To analyze spectral-domain optical coherence tomography 
      (SD-OCT)-specific findings in the different stages of vitelliform macular 
      dystrophy (VMD). METHODS: Thirty-seven patients were prospectively recruited. All 
      the patients underwent a complete ophthalmologic examination, including 
      best-corrected visual acuity (BCVA), biomicroscopy, and SD-OCT. The examined 
      findings were vitelliform material, neurosensory detachment, intraretinal 
      hyperreflective foci, and the status of external limiting membrane, ellipsoid 
      zone, and retinal pigment epithelium. The primary outcome was the stratification 
      of SD-OCT findings in each VMD stage. Secondary outcomes included the description 
      of different characteristics related to intraretinal hyperreflective foci. 
      RESULTS: Outer retinal layers were preserved almost exclusively in stage 1 (range 
      70%-100%), whereas their disruption and absence were typical of stages 2 to 4 
      (83%-100%) and stage 5 (67%-83%), respectively. Vitelliform material was found 
      always in stages 2 and 3, 89% of stage 4, and rarely in stage 5 (33%). 
      Neurosensory detachment was to some extent representative of stages 3 and 4 (80% 
      and 72%, respectively) when compared with the other stages (p<0.001). 
      Hyperreflective foci (16% of all eyes) demonstrated a progressive increase across 
      stages 2 to 4, with slightly reduced figure in stage 5. These foci were located 
      in the outer nuclear and plexiform layers, showed different sizes, and were not 
      associated with a visual acuity reduction (p = 0.64). CONCLUSIONS: A progressive 
      deterioration of the outer retinal layers was noticeable in more advanced stages 
      of VMD. The reduction of vitelliform material from stage 3 to 4 was paralleled by 
      an increased evidence of neurosensory detachment. Although showing different size 
      and location, hyperreflective foci did not correlate with worse BCVA.
FAU - Battaglia Parodi, Maurizio
AU  - Battaglia Parodi M
AD  -  Department of Ophthalmology, IRCCS Osepdale San Raffaele, University 
      Vita-Salute, Milan - Italy.
FAU - Iacono, Pierluigi
AU  - Iacono P
AD  -  IRCCS Fondazione G. B. Bietti per l'Oftalmologia, Rome - Italy.
FAU - Romano, Francesco
AU  - Romano F
AD  -  Department of Ophthalmology, IRCCS Osepdale San Raffaele, University 
      Vita-Salute, Milan - Italy.
FAU - Bolognesi, Gianluigi
AU  - Bolognesi G
AD  -  Department of Ophthalmology, IRCCS Osepdale San Raffaele, University 
      Vita-Salute, Milan - Italy.
FAU - Fasce, Francesco
AU  - Fasce F
AD  -  Department of Ophthalmology, IRCCS Osepdale San Raffaele, University 
      Vita-Salute, Milan - Italy.
FAU - Bandello, Francesco
AU  - Bandello F
AD  -  Department of Ophthalmology, IRCCS Osepdale San Raffaele, University 
      Vita-Salute, Milan - Italy.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170222
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Basement Membrane/pathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retina/diagnostic imaging/*pathology
MH  - Retinal Pigment Epithelium/diagnostic imaging/pathology
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity/physiology
MH  - Vitelliform Macular Dystrophy/diagnostic imaging/*pathology/physiopathology
MH  - Young Adult
EDAT- 2017/02/25 06:00
MHDA- 2017/03/31 06:00
CRDT- 2017/02/25 06:00
PHST- 2016/08/28 00:00 [accepted]
PHST- 2017/02/25 06:00 [pubmed]
PHST- 2017/03/31 06:00 [medline]
PHST- 2017/02/25 06:00 [entrez]
AID - 44294741-449E-4070-852F-784E51B62FBD [pii]
AID - 10.5301/ejo.5000878 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2017 Mar 10;27(2):201-204. doi: 10.5301/ejo.5000878. Epub 2017 
      Feb 22.