PMID- 28234144
OWN - NLM
STAT- MEDLINE
DCOM- 20170421
LR  - 20170421
IS  - 1945-8932 (Electronic)
IS  - 1945-8932 (Linking)
VI  - 31
IP  - 1
DP  - 2017 Jan 1
TI  - The association of allergic sensitization with radiographic sinus opacification.
PG  - 12-15
LID - 10.2500/ajra.2017.31.4394 [doi]
AB  - BACKGROUND: The relationship between allergic sensitization and radiographic 
      sinus inflammation remains unclear. OBJECTIVES: To determine whether specific 
      allergen sensitization is correlated with sinonasal radiographic opacification. 
      METHODS: Patients with chronic sinonasal symptoms were selected and included if 
      they had allergy testing and a computed tomography (CT) of the paranasal sinuses. 
      Data regarding demographic characteristics, in vitro allergy test results, and 
      comorbidities were collected. CTs were reviewed, and an overall Lund-Mackay score 
      (LMS) was calculated for each patient. A two-sample t-test was used to compare 
      mean LMS between patients who were sensitized and patients who were not 
      sensitized. A multiple linear regression model was used to determine whether a 
      relationship existed among LMS and allergy results, asthma, nasal polyps, 
      immunoglobulin E (IgE) level, medication usage, in-season versus out-of-season 
      CTs, age, and sex. Significance was determined at an alpha level of 0.05. 
      RESULTS: There were 437 patients included, of whom, 251 had positive specific 
      allergen test results and 186 had negative test results. A total of 282 patients 
      had allergic rhinitis symptoms without a documented diagnosis of sinusitis, and 
      155 carried a diagnosis of chronic rhinosinusitis. The mean LMS did not differ 
      between patients who were sensitized and patients who were not sensitized (5.56 
      versus 5.28; p = 0.61). Linear regression demonstrated an increase in LMS in 
      patients with asthma (p = 0.02), male sex (p < 0.01), elevated IgE (p < 0.01), a 
      history of anaphylaxis (p = 0.03), and nasal polyps (p < 0.01). There was a 
      statistically significant decrease in LMS in patients with an in-season CT (p = 
      0.02). CONCLUSIONS: Patients with a positive specific in vitro allergen test 
      result did not have higher overall rates of radiographic sinus inflammation. 
      Asthma, male sex, polyps, elevated IgE, and a history of anaphylaxis were 
      associated with higher LMS.
FAU - Brook, Christopher D
AU  - Brook CD
AD  - Department of Otolaryngology-Head and Neck Surgery, Boston University School of 
      Medicine, Boston, Massachusetts, USA.
FAU - Kuperstock, Jacob E
AU  - Kuperstock JE
FAU - Rubin, Samuel J
AU  - Rubin SJ
FAU - Ryan, Matthew W
AU  - Ryan MW
FAU - Platt, Michael P
AU  - Platt MP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Rhinol Allergy
JT  - American journal of rhinology & allergy
JID - 101490775
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens/immunology
MH  - Chronic Disease
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Immunization
MH  - Immunoglobulin E/blood
MH  - Inflammation/*epidemiology
MH  - Male
MH  - Nasal Polyps/*epidemiology
MH  - Paranasal Sinuses/*diagnostic imaging/immunology
MH  - Rhinitis, Allergic/*epidemiology
MH  - Sex Factors
MH  - Sinusitis/*epidemiology
MH  - Skin Tests
MH  - Tomography, X-Ray Computed
MH  - United States/epidemiology
EDAT- 2017/02/25 06:00
MHDA- 2017/04/22 06:00
CRDT- 2017/02/25 06:00
PHST- 2017/02/25 06:00 [entrez]
PHST- 2017/02/25 06:00 [pubmed]
PHST- 2017/04/22 06:00 [medline]
AID - 10.2500/ajra.2017.31.4394 [doi]
PST - ppublish
SO  - Am J Rhinol Allergy. 2017 Jan 1;31(1):12-15. doi: 10.2500/ajra.2017.31.4394.