PMID- 28237130
OWN - NLM
STAT- MEDLINE
DCOM- 20180626
LR  - 20191210
IS  - 1578-1267 (Electronic)
IS  - 0301-0546 (Linking)
VI  - 45
IP  - 5
DP  - 2017 Sep-Oct
TI  - The efficacy and safety of sublingual immunotherapy in children and adult 
      patients with allergic rhinitis.
PG  - 457-462
LID - S0301-0546(17)30007-1 [pii]
LID - 10.1016/j.aller.2016.10.016 [doi]
AB  - BACKGROUND: Clinical research has shown that sublingual immunotherapy (SLIT) is 
      effective and safe in moderate-severe allergic rhinitis (AR) induced by house 
      dust mite (HDM). However, the sample size in many studies is small. Meanwhile, 
      the controversy on the efficacy and safety in the very young children younger 
      than four years old still existed. OBJECTIVE: The aim of this retrospective study 
      is to evaluate the efficacy and safety of SLIT with Dermatophagoides farinae 
      (Der.f) extracts in children and adult patients with allergic rhinitis, 
      particularly in the very young children. METHOD: A total of 573 subjects aged 
      3-69 with AR received a three-year course of sublingual immunotherapy with Der.f 
      extracts along with pharmacotherapy. The total nasal symptoms score (TNSS), total 
      medication score (TMS), visual analogue score (VAS) and adverse events (AEs) were 
      evaluated at each visit. RESULT: TNSS, TMS, VAS were significantly improved 
      during the three-year course of treatment in comparison to the baseline values 
      (P<0.01). Besides, significant improvement in nasal symptoms and reduction of 
      medication use were also observed in young children aged 3-6 years (P<0.01). No 
      severe systemic adverse events (AEs) were reported. CONCLUSION: SLIT with Der.f 
      drops is clinically effective and safe in children and adult patients with 
      HDM-induced AR, including the very young children less than four years old.
CI  - Copyright (c) 2017 SEICAP. Published by Elsevier Espana, S.L.U. All rights 
      reserved.
FAU - Lin, X
AU  - Lin X
AD  - Department of Otorhinolaryngology & Head and Neck Surgery, Hainan General 
      Hospital, Haikou 570311, China. Electronic address: linxia3073@126.com.
FAU - Lin, H
AU  - Lin H
AD  - Department of Otorhinolaryngology, The Affiliated Hospital of Qingdao University, 
      Qingdao 266003, China.
FAU - Wei, X
AU  - Wei X
AD  - Department of Otorhinolaryngology & Head and Neck Surgery, Hainan General 
      Hospital, Haikou 570311, China.
FAU - Huang, Q
AU  - Huang Q
AD  - Department of Otorhinolaryngology & Head and Neck Surgery, Hainan General 
      Hospital, Haikou 570311, China.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20170222
PL  - Singapore
TA  - Allergol Immunopathol (Madr)
JT  - Allergologia et immunopathologia
JID - 0370073
RN  - 0 (Antigens, Dermatophagoides)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Antigens, Dermatophagoides/immunology/*therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Dermatophagoides farinae
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Rhinitis, Allergic/immunology/*therapy
MH  - Sublingual Immunotherapy/*methods
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - Dermatophagoides farinae
OT  - Efficacy
OT  - Sublingual immunotherapy
OT  - Young children
EDAT- 2017/02/27 06:00
MHDA- 2018/06/27 06:00
CRDT- 2017/02/27 06:00
PHST- 2016/09/23 00:00 [received]
PHST- 2016/10/31 00:00 [accepted]
PHST- 2017/02/27 06:00 [pubmed]
PHST- 2018/06/27 06:00 [medline]
PHST- 2017/02/27 06:00 [entrez]
AID - S0301-0546(17)30007-1 [pii]
AID - 10.1016/j.aller.2016.10.016 [doi]
PST - ppublish
SO  - Allergol Immunopathol (Madr). 2017 Sep-Oct;45(5):457-462. doi: 
      10.1016/j.aller.2016.10.016. Epub 2017 Feb 22.