PMID- 28237476
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2352-4146 (Electronic)
IS  - 1995-7645 (Linking)
VI  - 10
IP  - 2
DP  - 2017 Feb
TI  - Effects of albendazole, artesunate, praziquantel and miltefosine, on Opisthorchis 
      viverrini cercariae and mature metacercariae.
PG  - 126-133
LID - S1995-7645(17)30112-8 [pii]
LID - 10.1016/j.apjtm.2017.01.019 [doi]
AB  - OBJECTIVE: To explore larvicidal effects of anthelmintic drugs on Opisthorchis 
      viverrini (O. viverrini) for alternative approach to interrupting its cycle for 
      developing a field-based control program. METHODS: The larvicidal activities of 
      albendazole (Al), artesunate (Ar), praziquantel (Pzq) and miltefosine (Mf) on 
      O. viverrini cercariae and mature metacercariae were investigated. Lethal 
      concentrations (LC(50) and LC(95)) of these drugs were determined. Mature 
      metacercariae previously exposed to various concentrations of the drugs were 
      administered to hamsters. Worms were harvested 30 d post infection and worm 
      recovery rates calculated. Al, Ar, Pzq and Mf produced morphological degeneration 
      and induced shedding tails of cercariae after 24 h exposure. RESULTS: The LC(50) 
      and LC(95) of Al, Ar, Pzq and Mf on cercariae were 0.720 and 1.139, 0.350 and 
      0.861, 0.017 and 0.693, and 0.530 and 1.134 ppm, respectively. LC(50) and LC(95) 
      of Ar on mature metacercariae were 303.643 and 446.237 ppm and of Mf were 289.711 
      and 631.781 ppm, respectively but no lethal effect in Pzq- and Al-treated groups 
      (up to 1 ppt). No worms were found in hamsters administered Pzq-treated 
      metacercariae. The adult worms from Al-treated metacercariae were significantly 
      bigger in size compared to the control group (P < 0.05). Fecundity and body width 
      were greater in adults from Mf-treated metacercariae compared to the control 
      group (P < 0.05). CONCLUSIONS: The larvicidal effects of these drugs were high 
      efficacy to O. viverrini cercariae but lesser efficacy to metacercariae. It 
      should be further studied with the eventual aim of developing a field-based 
      control program.
CI  - Copyright (c) 2017 Hainan Medical University. Production and hosting by Elsevier 
      B.V. All rights reserved.
FAU - Pechdee, Phornphitcha
AU  - Pechdee P
AD  - Food-Borne Parasite Research Group, Department of Parasitology, Faculty of 
      Medicine, Khon Kaen University, Khon Kaen, Thailand.
FAU - Chaiyasaeng, Monticha
AU  - Chaiyasaeng M
AD  - Food-Borne Parasite Research Group, Department of Parasitology, Faculty of 
      Medicine, Khon Kaen University, Khon Kaen, Thailand.
FAU - Sereewong, Chanisala
AU  - Sereewong C
AD  - Food-Borne Parasite Research Group, Department of Parasitology, Faculty of 
      Medicine, Khon Kaen University, Khon Kaen, Thailand.
FAU - Chaiyos, Jukkrid
AU  - Chaiyos J
AD  - Food-Borne Parasite Research Group, Department of Parasitology, Faculty of 
      Medicine, Khon Kaen University, Khon Kaen, Thailand.
FAU - Suwannatrai, Apiporn
AU  - Suwannatrai A
AD  - Food-Borne Parasite Research Group, Department of Parasitology, Faculty of 
      Medicine, Khon Kaen University, Khon Kaen, Thailand.
FAU - Wongmaneeprateep, Sutee
AU  - Wongmaneeprateep S
AD  - Department of Fisheries, Faculty of Agriculture, Khon Kaen University, Khon Kaen, 
      Thailand.
FAU - Tesana, Smarn
AU  - Tesana S
AD  - Food-Borne Parasite Research Group, Department of Parasitology, Faculty of 
      Medicine, Khon Kaen University, Khon Kaen, Thailand. Electronic address: 
      smarn_te@kku.ac.th.
LA  - eng
PT  - Journal Article
DEP - 20170121
PL  - India
TA  - Asian Pac J Trop Med
JT  - Asian Pacific journal of tropical medicine
JID - 101533720
OTO - NOTNLM
OT  - Albendazole
OT  - Artesunate
OT  - Cercariae
OT  - Miltefosine
OT  - Opisthorchis viverrini
OT  - Praziquantel
EDAT- 2017/02/27 06:00
MHDA- 2017/02/27 06:01
CRDT- 2017/02/27 06:00
PHST- 2016/08/31 00:00 [received]
PHST- 2016/12/10 00:00 [revised]
PHST- 2017/01/03 00:00 [accepted]
PHST- 2017/02/27 06:00 [entrez]
PHST- 2017/02/27 06:00 [pubmed]
PHST- 2017/02/27 06:01 [medline]
AID - S1995-7645(17)30112-8 [pii]
AID - 10.1016/j.apjtm.2017.01.019 [doi]
PST - ppublish
SO  - Asian Pac J Trop Med. 2017 Feb;10(2):126-133. doi: 10.1016/j.apjtm.2017.01.019. 
      Epub 2017 Jan 21.