PMID- 28237545
OWN - NLM
STAT- MEDLINE
DCOM- 20170905
LR  - 20171205
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1662
DP  - 2017 May 1
TI  - Enhancement of brain plasticity and recovery of locomotive function after lumbar 
      spinal cord stimulation in combination with gait training with partial weight 
      support in rats with cerebral ischemia.
PG  - 31-38
LID - S0006-8993(17)30079-3 [pii]
LID - 10.1016/j.brainres.2017.02.017 [doi]
AB  - Lumbar spinal cord stimulation (LSCS) is reportedly effective for the recovery of 
      locomotive intraspinal neural network, motor cortex and basal ganglia in animals 
      with complete spinal cord injury and parkinsonism. We evaluated the effect of 
      LSCS in combination with gait training on the recovery of locomotive function and 
      brain plasticity using a rat model of brain ischemia. Adult male Sprague Dawley 
      rats with ischemia were randomly assigned into one of four groups: sham treatment 
      (group 1), LSCS only (group 2), LSCS with gait training and 50% (group 3) and 80% 
      (group 4) of body weight support. Evaluations before randomization and 4weeks 
      after intervention included motor scoring index, real-time PCR and Western blot. 
      Motor scoring index was significantly improved after the intervention in groups 2 
      and 3. The ratio of phospho-protein kinase C (PKC) to PKC measured in the 
      infarcted area tended to be higher in groups 3 and 4. Protein expression of 
      mGluR2 and mRNA expression of mGluR1 measured in the contralateral cortex were 
      lower in groups 3 and 4. The ratio of phospho-Akt to Akt and mRNA expression of 
      vascular endothelial growth factor measured in the ischemic border zone were 
      higher in group 2. The mRNA expression of MAP1b measured in the infarcted area 
      was significantly higher in group 2. The findings suggest that LSCS and gait 
      training with an adequate amount of body weight support may promote brain 
      plasticity and facilitate the functional recovery.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Choi, Yoon-Hee
AU  - Choi YH
AD  - Department of Rehabilitation Medicine, Seoul National University College of 
      Medicine, Seoul National University Hospital, Seoul, South Korea; Department of 
      Physical Medicine and Rehabilitation, Soonchunhyang University College of 
      Medicine, Soonchunhyang University Hospital, Seoul, South Korea.
FAU - Lee, Shi-Uk
AU  - Lee SU
AD  - Department of Rehabilitation Medicine, Seoul National University College of 
      Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical 
      Center, Seoul, South Korea. Electronic address: paindoc@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170222
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - Brain/metabolism
MH  - Brain Ischemia/metabolism
MH  - Cerebral Infarction/metabolism
MH  - Disease Models, Animal
MH  - Exercise Therapy/*methods/veterinary
MH  - Gait
MH  - Infarction, Middle Cerebral Artery/metabolism
MH  - Male
MH  - Motor Activity
MH  - Motor Cortex/physiopathology
MH  - Neuronal Plasticity/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recovery of Function
MH  - Spinal Cord/metabolism
MH  - Spinal Cord Injuries/*physiopathology/*therapy
MH  - Spinal Cord Stimulation/methods
MH  - Stroke
OTO - NOTNLM
OT  - Brain ischemia
OT  - Plasticity
OT  - Recovery
OT  - Rehabilitation
OT  - Spinal cord stimulation
OT  - Stroke
EDAT- 2017/02/27 06:00
MHDA- 2017/09/07 06:00
CRDT- 2017/02/27 06:00
PHST- 2016/11/07 00:00 [received]
PHST- 2017/02/14 00:00 [revised]
PHST- 2017/02/15 00:00 [accepted]
PHST- 2017/02/27 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
PHST- 2017/02/27 06:00 [entrez]
AID - S0006-8993(17)30079-3 [pii]
AID - 10.1016/j.brainres.2017.02.017 [doi]
PST - ppublish
SO  - Brain Res. 2017 May 1;1662:31-38. doi: 10.1016/j.brainres.2017.02.017. Epub 2017 
      Feb 22.