PMID- 28237819
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20220321
IS  - 1879-3061 (Electronic)
IS  - 1043-2760 (Print)
IS  - 1043-2760 (Linking)
VI  - 28
IP  - 5
DP  - 2017 May
TI  - The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.
PG  - 319-339
LID - S1043-2760(17)30016-4 [pii]
LID - 10.1016/j.tem.2017.01.004 [doi]
AB  - Having healthy adipose tissue is essential for metabolic fitness. This is clear 
      from the obesity epidemic, which is unveiling a myriad of comorbidities 
      associated with excess adipose tissue including type 2 diabetes, cardiovascular 
      disease, and cancer. Lipodystrophy also causes insulin resistance, emphasizing 
      the importance of having a balanced amount of fat. In cells, the mechanistic 
      target of rapamycin (mTOR) complexes 1 and 2 (mTORC1 and mTORC2, respectively) 
      link nutrient and hormonal signaling with metabolism, and recent studies are 
      shedding new light on their in vivo roles in adipocytes. In this review, we 
      discuss how recent advances in adipose tissue and mTOR biology are converging to 
      reveal new mechanisms that maintain healthy adipose tissue, and discuss ongoing 
      mysteries of mTOR signaling, particularly for the less understood complex mTORC2.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Lee, Peter L
AU  - Lee PL
AD  - Program in Molecular Medicine, University of Massachusetts Medical School, 373 
      Plantation Street, Worcester, MA 01605, USA.
FAU - Jung, Su Myung
AU  - Jung SM
AD  - Program in Molecular Medicine, University of Massachusetts Medical School, 373 
      Plantation Street, Worcester, MA 01605, USA.
FAU - Guertin, David A
AU  - Guertin DA
AD  - Program in Molecular Medicine, University of Massachusetts Medical School, 373 
      Plantation Street, Worcester, MA 01605, USA. Electronic address: 
      david.guertin@umassmed.edu.
LA  - eng
GR  - F30 AA024385/AA/NIAAA NIH HHS/United States
GR  - R01 CA196986/CA/NCI NIH HHS/United States
GR  - R01 DK094004/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170222
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 2)
SB  - IM
MH  - Adipocytes/*metabolism
MH  - Animals
MH  - Humans
MH  - Insulin Resistance/genetics/physiology
MH  - Lipodystrophy/*metabolism
MH  - Mechanistic Target of Rapamycin Complex 1/*metabolism/physiology
MH  - Mechanistic Target of Rapamycin Complex 2/*metabolism/physiology
MH  - Signal Transduction/genetics/physiology
PMC - PMC5682923
MID - NIHMS855145
EDAT- 2017/02/27 06:00
MHDA- 2018/02/13 06:00
PMCR- 2018/05/01
CRDT- 2017/02/27 06:00
PHST- 2016/11/28 00:00 [received]
PHST- 2017/01/20 00:00 [revised]
PHST- 2017/01/23 00:00 [accepted]
PHST- 2017/02/27 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
PHST- 2017/02/27 06:00 [entrez]
PHST- 2018/05/01 00:00 [pmc-release]
AID - S1043-2760(17)30016-4 [pii]
AID - 10.1016/j.tem.2017.01.004 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2017 May;28(5):319-339. doi: 10.1016/j.tem.2017.01.004. 
      Epub 2017 Feb 22.