PMID- 28237914
OWN - NLM
STAT- MEDLINE
DCOM- 20180214
LR  - 20220311
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 89
DP  - 2017 May
TI  - Apigenin attenuates hippocampal oxidative events, inflammation and pathological 
      alterations in rats fed high fat, fructose diet.
PG  - 323-331
LID - S0753-3322(16)32460-X [pii]
LID - 10.1016/j.biopha.2017.01.162 [doi]
AB  - High calorie diet promotes oxidative stress and chronic low grade inflammation 
      that predispose to brain dysfunction and neurodegeneration. Hippocampus region of 
      the brain has been shown to be particularly sensitive to high calorie diet. We 
      hypothesize that apigenin (API), a flavonoid could attenuate hippocampal 
      derangements induced by high fat-high fructose diet (HFFD). In this study, we 
      investigated the effects of API on oxidative stress and inflammation in the 
      hippocampus, and compared with those of sitagliptin (STG), a standard drug with 
      neuroprotective properties. The markers of oxidative stress and inflammation were 
      examined using biochemical assays, western blotting and immunohistochemistry 
      techniques. HFFD-fed rats showed severe pathological alterations and API 
      treatment rescued the hippocampus from the derangements. API significantly 
      improved the antioxidant machinery, reduced ROS levels and prevented the 
      activation of the stress kinases, inhibitor of kappa B kinase beta (IKKbeta) and 
      c-Jun NH2 terminal kinase (JNK), and the nuclear translocation and activation of 
      nuclear factor kappa B (NF-kappaB). The plasma levels of inflammatory cytokines were 
      also reduced. Our findings suggest that hippocampal derangements triggered by 
      HFFD feeding were effectively curtailed by API. Suppression of oxidative stress, 
      NF-kappaB activation and JNK phosphorylation in the hippocampus are the mechanisms by 
      which API offers neuroprotection in this model.
CI  - Copyright (c) 2017 Elsevier Masson SAS. All rights reserved.
FAU - Kalivarathan, Jagan
AU  - Kalivarathan J
AD  - Department of Biochemistry and Biotechnology, Annamalai University, Annamalai 
      Nagar 608 002, Tamil Nadu, India.
FAU - Chandrasekaran, Sathiya Priya
AU  - Chandrasekaran SP
AD  - Department of Biochemistry and Biotechnology, Annamalai University, Annamalai 
      Nagar 608 002, Tamil Nadu, India.
FAU - Kalaivanan, Kalpana
AU  - Kalaivanan K
AD  - Department of Biochemistry and Biotechnology, Annamalai University, Annamalai 
      Nagar 608 002, Tamil Nadu, India.
FAU - Ramachandran, Vidhya
AU  - Ramachandran V
AD  - Department of Biochemistry and Biotechnology, Annamalai University, Annamalai 
      Nagar 608 002, Tamil Nadu, India.
FAU - Carani Venkatraman, Anuradha
AU  - Carani Venkatraman A
AD  - Department of Biochemistry and Biotechnology, Annamalai University, Annamalai 
      Nagar 608 002, Tamil Nadu, India. Electronic address: cvaradha@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20170224
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Flavonoids)
RN  - 0 (Insulin)
RN  - 0 (NF-kappa B)
RN  - 30237-26-4 (Fructose)
RN  - 7V515PI7F6 (Apigenin)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - Apigenin/*pharmacology
MH  - Biomarkers/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Flavonoids/pharmacology
MH  - Fructose/adverse effects
MH  - Hippocampus/*drug effects/metabolism
MH  - Inflammation/*drug therapy/metabolism
MH  - Insulin/metabolism
MH  - Insulin Resistance/physiology
MH  - JNK Mitogen-Activated Protein Kinases/metabolism
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - NF-kappa B/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Phosphorylation/drug effects
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Apigenin
OT  - High calorie diet
OT  - Hippocampus
OT  - Inflammation
OT  - Oxidative stress
OT  - Sitagliptin
EDAT- 2017/02/27 06:00
MHDA- 2018/02/15 06:00
CRDT- 2017/02/27 06:00
PHST- 2016/11/23 00:00 [received]
PHST- 2017/01/23 00:00 [revised]
PHST- 2017/01/29 00:00 [accepted]
PHST- 2017/02/27 06:00 [pubmed]
PHST- 2018/02/15 06:00 [medline]
PHST- 2017/02/27 06:00 [entrez]
AID - S0753-3322(16)32460-X [pii]
AID - 10.1016/j.biopha.2017.01.162 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2017 May;89:323-331. doi: 10.1016/j.biopha.2017.01.162. Epub 
      2017 Feb 24.