PMID- 28238233
OWN - NLM
STAT- MEDLINE
DCOM- 20180419
LR  - 20180419
IS  - 0966-8519 (Print)
IS  - 0966-8519 (Linking)
VI  - 25
IP  - 5
DP  - 2016 Sep
TI  - Cardiac Fibrosis in Aortic Stenosis and Hypertensive Heart Disease Assessed by 
      Magnetic Resonance T1 Mapping.
PG  - 527-533
LID - 4358 [pii]
AB  - BACKGROUND: Continuous pressure overload may lead to subclinical myocardial 
      tissue changes in patients with hypertensive heart disease (HHD) and aortic 
      stenosis (AS). The study aim was to detect interstitial fibrosis using 
      quantitative cardiovascular magnetic resonance. METHODS: Fifteen patients with 
      HHD (arterial hypertension + septal wall thickness >/=13 mm), 33 with AS (eight 
      mild, 15 moderate, 10 severe), and 60 healthy controls were enrolled. Native T1 
      maps (modified Look-Locker inversion recovery) were obtained in a basal, 
      mid-ventricular, and apical shortaxis slice of the left ventricle to assess 
      cardiac fibrosis. Focal fibrosis was assessed with late gadolinium enhancement 
      (LGE). RESULTS: Patients with HHD and controls did not differ regarding the 
      native myocardial T1 values, both per slice and per segment. In AS patients, 
      apical native T1 values were lower than in controls, and there was a trend 
      towards higher T1 values in the septum in severe AS (1172.6 +/- 62.0 ms versus 
      1152.9 +/- 43.9 ms). Five HHD patients and 11 AS patients had non-ischemic fibrosis 
      in LGE images. Native T1 times did not differ between LGE-positive and 
      LGEnegative groups (both with inclusion and exclusion of segments with LGE). 
      CONCLUSIONS: T1 mapping did not reveal any evidence of abnormal interstitial 
      fibrosis in HHD subjects with mild hypertrophy. In severe AS, a trend towards 
      more interstitial fibrosis was present, but absolute differences were small for 
      decision making.
FAU - von Knobelsdorff-Brenkenhoff, Florian
AU  - von Knobelsdorff-Brenkenhoff F
AD  - Working Group Cardiovascular Magnetic Resonance, Experimental and Clinical 
      Research Center and HELIOS Klinikum Berlin Buch, Department of Cardiology and 
      Nephrology, Berlin, Germany. Electronic correspondence: 
      florian.von-knobelsdorff@charite.de.
FAU - Mueller, Anna-Katharina
AU  - Mueller AK
AD  - Working Group Cardiovascular Magnetic Resonance, Experimental and Clinical 
      Research Center and HELIOS Klinikum Berlin Buch, Department of Cardiology and 
      Nephrology, Berlin, Germany.
FAU - Prothmann, Marcel
AU  - Prothmann M
AD  - Working Group Cardiovascular Magnetic Resonance, Experimental and Clinical 
      Research Center and HELIOS Klinikum Berlin Buch, Department of Cardiology and 
      Nephrology, Berlin, Germany.
FAU - Hennig, Pierre
AU  - Hennig P
AD  - Working Group Cardiovascular Magnetic Resonance, Experimental and Clinical 
      Research Center and HELIOS Klinikum Berlin Buch, Department of Cardiology and 
      Nephrology, Berlin, Germany.
FAU - Dieringer, Matthias A
AU  - Dieringer MA
AD  - Working Group Cardiovascular Magnetic Resonance, Experimental and Clinical 
      Research Center and HELIOS Klinikum Berlin Buch, Department of Cardiology and 
      Nephrology, Berlin, Germany.
FAU - Schmacht, Luisa
AU  - Schmacht L
AD  - Working Group Cardiovascular Magnetic Resonance, Experimental and Clinical 
      Research Center and HELIOS Klinikum Berlin Buch, Department of Cardiology and 
      Nephrology, Berlin, Germany.
FAU - Greiser, Andreas
AU  - Greiser A
AD  - Siemens Healthcare GmbH, Erlangen, Germany.
FAU - Schulz-Menger, Jeanette
AU  - Schulz-Menger J
AD  - German Center for Cardiovascular Research (DZHK), partner site Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Heart Valve Dis
JT  - The Journal of heart valve disease
JID - 9312096
SB  - IM
MH  - Aged
MH  - Aortic Valve Stenosis/diagnostic imaging/*pathology
MH  - Female
MH  - Fibrosis
MH  - Heart/diagnostic imaging
MH  - Heart Diseases/diagnostic imaging/*pathology
MH  - Humans
MH  - Hypertension/diagnostic imaging/*pathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
EDAT- 2017/02/27 06:00
MHDA- 2018/04/20 06:00
CRDT- 2017/02/27 06:00
PHST- 2017/02/27 06:00 [entrez]
PHST- 2017/02/27 06:00 [pubmed]
PHST- 2018/04/20 06:00 [medline]
AID - 4358 [pii]
PST - ppublish
SO  - J Heart Valve Dis. 2016 Sep;25(5):527-533.