PMID- 28238708
OWN - NLM
STAT- MEDLINE
DCOM- 20180426
LR  - 20210309
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 644
DP  - 2017 Mar 22
TI  - Brain-derived neurotrophic factor downregulates immunoglobulin heavy chain 
      binding protein expression after repeated cocaine administration in the rat 
      dorsal striatum.
PG  - 107-113
LID - S0304-3940(17)30179-9 [pii]
LID - 10.1016/j.neulet.2017.02.063 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a key molecule involved in the 
      regulation of glutamatergic neurotransmission in response to chronic stimulation 
      of psychostimulants. This study demonstrated that BDNF in the dorsal striatum 
      regulates the endoplasmic reticulum (ER) stress response after repeated exposure 
      to cocaine. The results showed that unilateral intracaudate infusion of BDNF 
      (0.40, 0.75, or 1.50mug/muL) decreased the repeated cocaine-induced increase in the 
      expression of immunoglobulin heavy chain binding protein (BiP) sensing unfolded 
      or misfolded proteins in a dose-dependent manner. Unilateral intracaudate 
      infusion of BDNF (0.75mug/muL) also decreased the phosphorylation of c-Jun 
      N-terminal kinase (JNK), which had been initially elevated by seven consecutive 
      daily intraperitoneal injections of cocaine (20mg/kg/day). These decreases were 
      reversed by unilateral intracaudate infusion of the specific tropomyosin receptor 
      kinase B (TrkB) antagonist, cyclotraxin B (1ng/muL). These findings suggest that 
      BDNF regulates the unfolded protein response via TrkB-linked JNK inactivation in 
      the dorsal striatum after repeated cocaine administration, thus contributing to 
      the restoration of the ER functions.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Kim, Jieun
AU  - Kim J
AD  - Department of Biological Sciences, Pusan National University, 63-2 
      Busandaehak-ro, Geumjeong-gu, Busan 46241, Republic of Korea.
FAU - Yang, Ju Hwan
AU  - Yang JH
AD  - Department of Biological Sciences, Pusan National University, 63-2 
      Busandaehak-ro, Geumjeong-gu, Busan 46241, Republic of Korea.
FAU - Ryu, In Soo
AU  - Ryu IS
AD  - Department of Biological Sciences, Pusan National University, 63-2 
      Busandaehak-ro, Geumjeong-gu, Busan 46241, Republic of Korea.
FAU - Choe, Eun Sang
AU  - Choe ES
AD  - Department of Biological Sciences, Pusan National University, 63-2 
      Busandaehak-ro, Geumjeong-gu, Busan 46241, Republic of Korea. Electronic address: 
      eschoe@pusan.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20170224
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (GRP78 protein, rat)
RN  - 0 (Heat-Shock Proteins)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Central Nervous System Stimulants/pharmacology
MH  - Cocaine/*pharmacology
MH  - Corpus Striatum/drug effects/*metabolism
MH  - Down-Regulation
MH  - Endoplasmic Reticulum Stress/drug effects/physiology
MH  - Heat-Shock Proteins/*biosynthesis
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Unfolded Protein Response/*drug effects/physiology
OTO - NOTNLM
OT  - ER stress
OT  - JNK
OT  - Neurotropic factor
OT  - Psychostimulant
OT  - UPR
EDAT- 2017/02/28 06:00
MHDA- 2018/04/27 06:00
CRDT- 2017/02/28 06:00
PHST- 2016/10/18 00:00 [received]
PHST- 2017/02/10 00:00 [revised]
PHST- 2017/02/22 00:00 [accepted]
PHST- 2017/02/28 06:00 [pubmed]
PHST- 2018/04/27 06:00 [medline]
PHST- 2017/02/28 06:00 [entrez]
AID - S0304-3940(17)30179-9 [pii]
AID - 10.1016/j.neulet.2017.02.063 [doi]
PST - ppublish
SO  - Neurosci Lett. 2017 Mar 22;644:107-113. doi: 10.1016/j.neulet.2017.02.063. Epub 
      2017 Feb 24.