PMID- 28238825
OWN - NLM
STAT- MEDLINE
DCOM- 20171213
LR  - 20180104
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 325
IP  - Pt A
DP  - 2017 May 15
TI  - Association between obesity-related biomarkers and cognitive and motor 
      development in infants.
PG  - 12-16
LID - S0166-4328(17)30052-9 [pii]
LID - 10.1016/j.bbr.2017.02.030 [doi]
AB  - BACKGROUND: This study aimed to verify the association between obesity-related 
      biomarkers and cognitive and motor development in infants between 6 and 24 months 
      of age. METHODS: A cross-sectional study was conducted with 50 infants and plasma 
      levels of leptin, adiponectin, resistin, soluble tumor necrosis factor receptors 
      1 and 2 (sTNFR1 and sTNFR2), chemokines, brain-derived neurotrophic factor 
      (BDNF), serum cortisol and redox status were measured. The Bayley-III test was 
      utilized to evaluate cognitive and motor development, and multiple linear 
      stepwise regression models were performed to verify the association between 
      selected biomarkers and cognitive and motor development. RESULTS: A significant 
      association was found among plasma leptin and sTNFR1 levels with cognitive 
      composite scores, and these two independents variables together explained 37% of 
      the variability of cognitive composite scores (p=0.001). Only plasma sTNFR1 
      levels were associated and explained 24% of the variability of motor composite 
      scores (p=0.003). CONCLUSIONS: Plasma levels of sTNFR1 were associated with the 
      increase in cognitive and motor development scores in infants between 6 and 24 
      months of age through a mechanism not directly related to excess body weight. 
      Moreover, increase in plasma levels of leptin reduced the cognitive development 
      in this age range.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Camargos, Ana Cristina R
AU  - Camargos AC
AD  - Departamento de Fisioterapia, Universidade Federal dos Vales do Jequitinhonha e 
      Mucuri, Diamantina, Minas Gerais, Brazil; Programa Multicentrico de Pos-Graduacao 
      em Ciencias Fisiologicas, Sociedade Brasileira de Fisiologia, Diamantina, Brazil. 
      Electronic address: anacristinarcamargos@gmail.com.
FAU - Mendonca, Vanessa A
AU  - Mendonca VA
AD  - Departamento de Fisioterapia, Universidade Federal dos Vales do Jequitinhonha e 
      Mucuri, Diamantina, Minas Gerais, Brazil; Programa Multicentrico de Pos-Graduacao 
      em Ciencias Fisiologicas, Sociedade Brasileira de Fisiologia, Diamantina, Brazil.
FAU - Oliveira, Katherine S C
AU  - Oliveira KS
AD  - Departamento de Fisioterapia, Universidade Federal dos Vales do Jequitinhonha e 
      Mucuri, Diamantina, Minas Gerais, Brazil.
FAU - de Andrade, Camila Alves
AU  - de Andrade CA
AD  - Departamento de Fisioterapia, Universidade Federal dos Vales do Jequitinhonha e 
      Mucuri, Diamantina, Minas Gerais, Brazil.
FAU - Leite, Hercules Ribeiro
AU  - Leite HR
AD  - Departamento de Fisioterapia, Universidade Federal dos Vales do Jequitinhonha e 
      Mucuri, Diamantina, Minas Gerais, Brazil; Programa Multicentrico de Pos-Graduacao 
      em Ciencias Fisiologicas, Sociedade Brasileira de Fisiologia, Diamantina, Brazil.
FAU - da Fonseca, Sueli Ferreira
AU  - da Fonseca SF
AD  - Programa Multicentrico de Pos-Graduacao em Ciencias Fisiologicas, Sociedade 
      Brasileira de Fisiologia, Diamantina, Brazil.
FAU - Vieira, Erica Leandro Marciano
AU  - Vieira EL
AD  - Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 
      Minas Gerais, Brazil.
FAU - Teixeira Junior, Antonio Lucio
AU  - Teixeira Junior AL
AD  - Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 
      Minas Gerais, Brazil.
FAU - Lacerda, Ana Cristina Rodrigues
AU  - Lacerda AC
AD  - Departamento de Fisioterapia, Universidade Federal dos Vales do Jequitinhonha e 
      Mucuri, Diamantina, Minas Gerais, Brazil; Programa Multicentrico de Pos-Graduacao 
      em Ciencias Fisiologicas, Sociedade Brasileira de Fisiologia, Diamantina, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170224
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Leptin)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Resistin)
RN  - 0 (TNFRSF1A protein, human)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adiponectin/blood
MH  - Biomarkers/blood
MH  - *Child Development
MH  - Child, Preschool
MH  - Cognition/*physiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Infant
MH  - Leptin/*blood
MH  - Male
MH  - *Motor Activity
MH  - Obesity/*blood/*psychology
MH  - Receptors, Tumor Necrosis Factor, Type I/*blood
MH  - Receptors, Tumor Necrosis Factor, Type II/blood
MH  - Resistin/blood
OTO - NOTNLM
OT  - Adipokines
OT  - Biomarkers
OT  - Child development
OT  - Infant obesity
EDAT- 2017/02/28 06:00
MHDA- 2017/12/14 06:00
CRDT- 2017/02/28 06:00
PHST- 2017/01/09 00:00 [received]
PHST- 2017/02/15 00:00 [revised]
PHST- 2017/02/18 00:00 [accepted]
PHST- 2017/02/28 06:00 [pubmed]
PHST- 2017/12/14 06:00 [medline]
PHST- 2017/02/28 06:00 [entrez]
AID - S0166-4328(17)30052-9 [pii]
AID - 10.1016/j.bbr.2017.02.030 [doi]
PST - ppublish
SO  - Behav Brain Res. 2017 May 15;325(Pt A):12-16. doi: 10.1016/j.bbr.2017.02.030. 
      Epub 2017 Feb 24.