PMID- 28239337
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 11
DP  - 2017
TI  - Local and Distant Dysregulation of Synchronization Around Interictal Spikes in 
      BECTS.
PG  - 59
LID - 10.3389/fnins.2017.00059 [doi]
LID - 59
AB  - Objective: High Density electroencephalography (HD EEG) is the reference 
      non-invasive technique to investigate the dynamics of neuronal networks in Benign 
      Epilepsy with Centro-Temporal Spikes (BECTS). Analysis of local dynamic changes 
      surrounding Interictal Epileptic Spikes (IES) might improve our knowledge of the 
      mechanisms that propel neurons to the hypersynchronization of IES in BECTS. 
      Transient distant changes in the dynamics of neurons populations may also 
      interact with neuronal networks involved in various functions that are impaired 
      in BECTS patients. Methods: HD EEG (64 electrodes) of eight well-characterized 
      BECTS patients (8 males; mean age: 7.2 years, range: 5-9 years) were analyzed. 
      Unilateral IES were selected in 6 patients. They were bilateral and independent 
      in 2 other patients. This resulted in a total of 10 groups of IES. Time-frequency 
      analysis was performed on HD EEG epochs around the peak of the IES (+/-1000 ms), 
      including phase-locked and non-phase-locked activities to the IES. The time 
      frequency analyses were calculated for the frequencies between 4 and 200 Hz. 
      Results: Time-frequency analysis revealed two patterns of dysregulation of the 
      synchronization between neuronal networks preceding and following 
      hypersynchronization of interictal spikes (+/-400 ms) in the epileptogenic zone. 
      Dysregulation consists of either desynchronization (n = 6) or oscillating 
      synchronization (n = 4) (4-50 Hz) surrounding the IES. The 2 patients with 
      bilateral IES exhibited only local desynchronization whatever the IES considered. 
      Distant desynchronization in low frequencies within the same window occurs 
      simultaneously in bilateral frontal, temporal and occipital areas (n = 7). 
      Significance: Using time-frequency analysis of HD EEG data in a well-defined 
      population of BECTS, we demonstrated repeated complex changes in the dynamics of 
      neuronal networks not only during, but also, before and after the IES. In the 
      epileptogenic zone, our results found more complex reorganization of the local 
      network than initially thought. In line with previous results obtained at a 
      microscopic or macroscopic level, these changes suggested the variability 
      strategies of neuronal assemblies to raise IES. Distant changes from the 
      epileptogenic zone in desynchronization observed in the same time window 
      suggested interactions between larger embedded networks and opened new avenues 
      about their possible role in the underlying mechanism leading to cognitive 
      deficits.
FAU - Bourel-Ponchel, Emilie
AU  - Bourel-Ponchel E
AD  - Institut National de la Sante et de la Recherche Medicale U 1105, GRAMFC, CURS, 
      CHU Amiens Picardie - Site SudSalouel, Amiens, France; Fonctional Exploration of 
      the Pediatric Nervous System, CHU Amiens Picardie - Site SudSalouel, Amiens, 
      France.
FAU - Mahmoudzadeh, Mahdi
AU  - Mahmoudzadeh M
AD  - Institut National de la Sante et de la Recherche Medicale U 1105, GRAMFC, CURS, 
      CHU Amiens Picardie - Site SudSalouel, Amiens, France; Fonctional Exploration of 
      the Pediatric Nervous System, CHU Amiens Picardie - Site SudSalouel, Amiens, 
      France.
FAU - Berquin, Patrick
AU  - Berquin P
AD  - Institut National de la Sante et de la Recherche Medicale U 1105, GRAMFC, CURS, 
      CHU Amiens Picardie - Site SudSalouel, Amiens, France; Neuropediatry Unit, CHU 
      Amiens Picardie - Site SudSalouel, Amiens, France.
FAU - Wallois, Fabrice
AU  - Wallois F
AD  - Institut National de la Sante et de la Recherche Medicale U 1105, GRAMFC, CURS, 
      CHU Amiens Picardie - Site SudSalouel, Amiens, France; Fonctional Exploration of 
      the Pediatric Nervous System, CHU Amiens Picardie - Site SudSalouel, Amiens, 
      France.
LA  - eng
PT  - Journal Article
DEP - 20170210
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC5301021
OTO - NOTNLM
OT  - BECTS
OT  - desynchronization
OT  - hypersynchronization
OT  - interictal epileptic spikes
OT  - pre-spike
OT  - time-frequency analysis
EDAT- 2017/02/28 06:00
MHDA- 2017/02/28 06:01
PMCR- 2017/01/01
CRDT- 2017/02/28 06:00
PHST- 2016/05/20 00:00 [received]
PHST- 2017/01/26 00:00 [accepted]
PHST- 2017/02/28 06:00 [entrez]
PHST- 2017/02/28 06:00 [pubmed]
PHST- 2017/02/28 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2017.00059 [doi]
PST - epublish
SO  - Front Neurosci. 2017 Feb 10;11:59. doi: 10.3389/fnins.2017.00059. eCollection 
      2017.