PMID- 28239959
OWN - NLM
STAT- MEDLINE
DCOM- 20180712
LR  - 20180712
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 18
IP  - 8
DP  - 2017 Dec
TI  - Type 1 diabetes in children and adolescents is not associated with a reduced 
      prevalence of atopy and allergic diseases.
PG  - 890-894
LID - 10.1111/pedi.12504 [doi]
AB  - BACKGROUND: Type 1 diabetes mellitus (T1D) as well as allergies in childhood have 
      increased worldwide during the last 2 decades. The reasons for this increase are 
      still unknown but early life origins are being discussed, such as dietary and 
      hygiene factors that may play a role in the development of both diseases. The aim 
      of this study was to compare the prevalence of allergies in children with and 
      without T1D and to define potential influencing factors. MATERIALS AND METHODS: 
      Data were collected from 104 patients with T1D (n = 104; mean age 11.4 +/- 4.4 
      years; m/f: 77/27) and 104 healthy controls (CG) (n = 104; mean age 11.4 +/- 4.3 
      years; m/f: 77/27). A questionnaire on allergic symptoms was obtained from each 
      individual. In parallel, ImmunoCAP tests to detect specific allergen 
      sensitization were performed. RESULTS: Allergen sensitization rates were not 
      significantly different between both groups (T1D: 42% vs CG 38%; P = 0.625). In 
      both groups, a comparable number of patients reported allergic symptoms in the 
      questionnaire (T1D: 20% vs CG 26%; P = 0.43). Allergen sensitization and allergic 
      symptoms were independent of breastfeeding, pets at home or diabetes duration. 
      However, in T1D, fewer family members smoked (T1D: 10% vs CG 56%; P < 0.001). 
      CONCLUSIONS: The present cohort study shows the same prevalence of allergy and 
      atopy in a pediatric diabetes population compared to healthy controls. Diabetes 
      per se does not seem to influence the development of allergies.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Jasser-Nitsche, Hildegard
AU  - Jasser-Nitsche H
AUID- ORCID: 0000-0002-1992-7565
AD  - Department of Pediatrics, Division of General Pediatrics, Medical University of 
      Graz, Graz, Austria.
FAU - Varga, Eva-Maria
AU  - Varga EM
AD  - Department of Pediatrics, Division of Respiratory and Allergic Disease, Medical 
      University of Graz, Graz, Austria.
FAU - Borkenstein, Helmuth Martin
AU  - Borkenstein HM
AD  - Department of Pediatrics, Division of General Pediatrics, Medical University of 
      Graz, Graz, Austria.
FAU - Hontzsch, Julia
AU  - Hontzsch J
AD  - Department of Pediatrics, Division of General Pediatrics, Medical University of 
      Graz, Graz, Austria.
FAU - Suppan, Elisabeth
AU  - Suppan E
AD  - Department of Pediatrics, Division of General Pediatrics, Medical University of 
      Graz, Graz, Austria.
FAU - Weinhandl, Gudrun
AU  - Weinhandl G
AD  - Department of Pediatrics, Division of General Pediatrics, Medical University of 
      Graz, Graz, Austria.
FAU - Pieringer, Lisa
AU  - Pieringer L
AD  - Department of Pediatrics, Division of General Pediatrics, Medical University of 
      Graz, Graz, Austria.
FAU - Avian, Alexander
AU  - Avian A
AD  - Institute for Medical Informatics, Statistics and Documentation, Medical 
      University of Graz, Graz, Austria.
FAU - Frohlich-Reiterer, Elke
AU  - Frohlich-Reiterer E
AD  - Department of Pediatrics, Division of General Pediatrics, Medical University of 
      Graz, Graz, Austria.
LA  - eng
PT  - Journal Article
DEP - 20170227
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Austria/epidemiology
MH  - Breast Feeding
MH  - Case-Control Studies
MH  - Child
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 1/complications/*epidemiology/immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/complications/*epidemiology
MH  - Immunoglobulin E
MH  - Male
MH  - Pets
MH  - Prevalence
OTO - NOTNLM
OT  - T1D
OT  - allergy
OT  - atopy
OT  - children
OT  - prevalence
EDAT- 2017/02/28 06:00
MHDA- 2018/07/13 06:00
CRDT- 2017/02/28 06:00
PHST- 2016/09/23 00:00 [received]
PHST- 2016/12/09 00:00 [revised]
PHST- 2016/12/28 00:00 [accepted]
PHST- 2017/02/28 06:00 [pubmed]
PHST- 2018/07/13 06:00 [medline]
PHST- 2017/02/28 06:00 [entrez]
AID - 10.1111/pedi.12504 [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2017 Dec;18(8):890-894. doi: 10.1111/pedi.12504. Epub 2017 Feb 
      27.