PMID- 28240271
OWN - NLM
STAT- MEDLINE
DCOM- 20181101
LR  - 20240324
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
DP  - 2017 Feb 27
TI  - Coherent activity between brain regions that code for value is linked to the 
      malleability of human behavior.
PG  - 43250
LID - 10.1038/srep43250 [doi]
LID - 43250
AB  - Brain activity in medial prefrontal cortex (MPFC) during exposure to persuasive 
      messages can predict health behavior change. This brain-behavior relationship has 
      been linked to areas of MPFC previously associated with self-related processing; 
      however, the mechanism underlying this relationship is unclear. We explore two 
      components of self-related processing - self-reflection and subjective valuation 
      - and examine coherent activity between relevant networks of brain regions during 
      exposure to health messages encouraging exercise and discouraging sedentary 
      behaviors. We find that objectively logged reductions in sedentary behavior in 
      the following month are linked to functional connectivity within brain regions 
      associated with positive valuation, but not within regions associated with 
      self-reflection on personality traits. Furthermore, functional connectivity 
      between valuation regions contributes additional information compared to average 
      brain activation within single brain regions. These data support an account in 
      which MPFC integrates the value of messages to the self during persuasive health 
      messaging and speak to broader questions of how humans make decisions about how 
      to behave.
FAU - Cooper, Nicole
AU  - Cooper N
AD  - Annenberg School for Communication, University of Pennsylvania, Philadelphia, PA, 
      USA.
AD  - US Army Research Laboratory, Aberdeen Proving Ground, MD, USA.
FAU - Bassett, Danielle S
AU  - Bassett DS
AD  - Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
AD  - Department of Electrical and Systems Engineering, University of Pennsylvania, 
      Philadelphia, PA, USA.
FAU - Falk, Emily B
AU  - Falk EB
AD  - Annenberg School for Communication, University of Pennsylvania, Philadelphia, PA, 
      USA.
LA  - eng
GR  - DP2 DA035156/DA/NIDA NIH HHS/United States
GR  - P50 CA101451/CA/NCI NIH HHS/United States
GR  - P50 CA179546/CA/NCI NIH HHS/United States
GR  - R01 CA180015/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20170227
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Connectome
MH  - Decision Making/*physiology
MH  - Exercise/psychology
MH  - Female
MH  - Health Behavior/physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/anatomy & histology/diagnostic imaging/*physiology
MH  - *Persuasive Communication
MH  - Prefrontal Cortex/anatomy & histology/diagnostic imaging/*physiology
MH  - Sedentary Behavior
MH  - *Self-Assessment
PMC - PMC5327429
COIS- The authors declare no competing financial interests.
EDAT- 2017/02/28 06:00
MHDA- 2018/11/02 06:00
PMCR- 2017/02/27
CRDT- 2017/02/28 06:00
PHST- 2016/09/14 00:00 [received]
PHST- 2017/01/20 00:00 [accepted]
PHST- 2017/02/28 06:00 [entrez]
PHST- 2017/02/28 06:00 [pubmed]
PHST- 2018/11/02 06:00 [medline]
PHST- 2017/02/27 00:00 [pmc-release]
AID - srep43250 [pii]
AID - 10.1038/srep43250 [doi]
PST - epublish
SO  - Sci Rep. 2017 Feb 27;7:43250. doi: 10.1038/srep43250.