PMID- 28241677
OWN - NLM
STAT- MEDLINE
DCOM- 20180427
LR  - 20181202
IS  - 1001-9391 (Print)
IS  - 1001-9391 (Linking)
VI  - 34
IP  - 12
DP  - 2016 Dec 20
TI  - [Association between H3K4me3/BDNF and the cognitive function of workers 
      occupationally exposed to aluminum].
PG  - 900-904
LID - 10.3760/cma.j.issn.1001-9391.2016.12.005 [doi]
AB  - Objective: To investigate the influence of occupational aluminum exposure on 
      cognitive function and its relationship with tri-methyl histone H3 lysine 
      residues 4 points (H3K4me3) and brain-derived neurotrophic factor (BDNF) levels. 
      Methods: By cluster random sampling method, a total of 235 cases of male workers 
      selected from a Shanxi aluminum factory were recruited in the study in September 
      2015. Used the occupational epidemiological investigation questionnaire, which 
      included Mini-Mental State Examination (MMSE) , Clock Drawing Test (CDT) , Digit 
      Span Test (DST, including forward test DSFT and backward test DSBT) , Fuild 
      Object Memory Evaluation (FOME) and Verbal Fluency Test (VFT) , to collect 
      workers' basic information and assess their cognitive function score. Detected 
      the concentration of aluminum in plasma by graphite furnace atomic absorption 
      spectrometry. Workers were divided into three groups by the 25 percentile and 75 
      percentile of the aluminum content, such as low, middle and high aluminum 
      concentration groups. The concentrations of H3K4me3 in lymphocyte and BDNF in 
      plasma were determined by enzyme-linked immunosorbent assay. Results: The levels 
      of aluminum in plasma was 134.36 (100.14, 178.96) mug/L. The scores of MMSE, DSFT, 
      DSBT, DST of high aluminum concentration group were lower than low aluminum group 
      (27.98+/-1.25 vs 28.83+/-1.54, 9.19+/-2.00 vs 10.64+/-2.87, 6.08+/-1.63 vs 7.19+/-3.07, 
      15.27+/-3.11 vs 17.81+/-4.72, all P<0.05) , the scores of CDT, FOME, VFT among three 
      groups had no statistical significance (all P>0.05) . The expression levels of 
      H3K4me3 and BDNF of high aluminum concentration group were lower than the low 
      group [ (18.45+/-9.81) ng/mug Pro vs (23.76+/-9.89) ng/mug Pro, (26.07+/-10.18) ng/ml vs 
      (31.66+/-9.24) ng/ml, all P<0.05]. Multiple correlation analysis showed that 
      aluminum concentration were negatively correlated toH3K4me3, BDNF, MMSE, DSFT, 
      DST, respectively (r(s)=-0.307、-0.214、-0.252、-0.197, -0.181, all P<0.01) . 
      Conclusion: Exposure to occupational aluminum for a long time may change 
      cognitive function, which go along with the decreasing of H3K4me3 level in 
      lymphocyte and BDNF protein expression in plasma.
FAU - Qiu, H Y
AU  - Qiu HY
AD  - Department of Occupational and Environmental Health, Shanxi Medical University, 
      Taiyuan 030001, China.
FAU - Ren, P
AU  - Ren P
FAU - Li, R
AU  - Li R
FAU - Zhang, Q L
AU  - Zhang QL
FAU - Lu, X T
AU  - Lu XT
FAU - Niu, Q
AU  - Niu Q
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
JT  - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng 
      zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
JID - 8410840
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - CPD4NFA903 (Aluminum)
SB  - IM
MH  - Aluminum/*toxicity
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition
MH  - Cognition Disorders/*etiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - *Occupational Exposure
MH  - Spectrophotometry, Atomic
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Aluminum
OT  - BDNF
OT  - Cognition
OT  - H3K4me3
OT  - Occupational exposure
EDAT- 2017/03/01 06:00
MHDA- 2018/04/28 06:00
CRDT- 2017/03/01 06:00
PHST- 2017/03/01 06:00 [entrez]
PHST- 2017/03/01 06:00 [pubmed]
PHST- 2018/04/28 06:00 [medline]
AID - 10.3760/cma.j.issn.1001-9391.2016.12.005 [doi]
PST - ppublish
SO  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2016 Dec 20;34(12):900-904. doi: 
      10.3760/cma.j.issn.1001-9391.2016.12.005.