PMID- 28243312
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2017
DP  - 2017
TI  - Acupuncture Improved Neurological Recovery after Traumatic Brain Injury by 
      Activating BDNF/TrkB Pathway.
PG  - 8460145
LID - 10.1155/2017/8460145 [doi]
LID - 8460145
AB  - How to promote neural repair following traumatic brain injury (TBI) has long been 
      an intractable problem. Although acupuncture has been demonstrated to facilitate 
      the neurological recovery, the underlying mechanism is elusive. Brain-derived 
      neurotrophic factor (BDNF) exerts substantial protective effects for neurological 
      disorders. In this study, we found that the level of BDNF and tropomyosin 
      receptor kinase B (TrkB) was elevated spontaneously after TBI and reached up to 
      the peak at 12 h. Nevertheless, this enhancement is quickly declined to the 
      normal at 48 h. After combined stimulation at the acupoints of Baihui, Renzhong, 
      Hegu, and Zusanli, we found that BDNF and TrkB were still significantly elevated 
      at 168 h. We also observed that the downstream molecular p-Akt and p-Erk1/2 were 
      significantly increased, suggesting that acupuncture could persistently activate 
      the BDNF/TrkB pathway. To further verify that acupuncture improved recovery 
      through activating BDNF/TrkB pathway, K252a (specific inhibitor of TrkB) was 
      treated by injection stereotaxically into lateral ventricle. We observed that 
      K252a could significantly prevent the acupuncture-induced amelioration of motor, 
      sensation, cognition, and synaptic plasticity. These data indicated that 
      acupuncture promoted the recovery of neurological impairment after TBI by 
      activating BDNF/TrkB signaling pathway, providing new molecular mechanism for 
      understanding traditional therapy of acupuncture.
FAU - Li, Xiaohong
AU  - Li X
AD  - Institute of Traumatic Brain Injury and Neurology, Pingjin Hospital, Logistics 
      University of Chinese People's Armed Police Forces, Tianjin 300162, China; Key 
      Laboratory of Neurotrauma Repair of Tianjin, Tianjin 300162, China.
FAU - Chen, Chong
AU  - Chen C
AD  - Institute of Traumatic Brain Injury and Neurology, Pingjin Hospital, Logistics 
      University of Chinese People's Armed Police Forces, Tianjin 300162, China; Key 
      Laboratory of Neurotrauma Repair of Tianjin, Tianjin 300162, China.
FAU - Yang, Xiping
AU  - Yang X
AD  - Institute of Traumatic Brain Injury and Neurology, Pingjin Hospital, Logistics 
      University of Chinese People's Armed Police Forces, Tianjin 300162, China; Key 
      Laboratory of Neurotrauma Repair of Tianjin, Tianjin 300162, China.
FAU - Wang, Jingjing
AU  - Wang J
AD  - Institute of Traumatic Brain Injury and Neurology, Pingjin Hospital, Logistics 
      University of Chinese People's Armed Police Forces, Tianjin 300162, China; Key 
      Laboratory of Neurotrauma Repair of Tianjin, Tianjin 300162, China.
FAU - Zhao, Ming-Liang
AU  - Zhao ML
AD  - Institute of Traumatic Brain Injury and Neurology, Pingjin Hospital, Logistics 
      University of Chinese People's Armed Police Forces, Tianjin 300162, China; Key 
      Laboratory of Neurotrauma Repair of Tianjin, Tianjin 300162, China.
FAU - Sun, Hongtao
AU  - Sun H
AD  - Institute of Traumatic Brain Injury and Neurology, Pingjin Hospital, Logistics 
      University of Chinese People's Armed Police Forces, Tianjin 300162, China; Key 
      Laboratory of Neurotrauma Repair of Tianjin, Tianjin 300162, China.
FAU - Zhang, Sai
AU  - Zhang S
AUID- ORCID: 0000-0002-8028-4183
AD  - Institute of Traumatic Brain Injury and Neurology, Pingjin Hospital, Logistics 
      University of Chinese People's Armed Police Forces, Tianjin 300162, China; Key 
      Laboratory of Neurotrauma Repair of Tianjin, Tianjin 300162, China.
FAU - Tu, Yue
AU  - Tu Y
AUID- ORCID: 0000-0001-5592-4751
AD  - Institute of Traumatic Brain Injury and Neurology, Pingjin Hospital, Logistics 
      University of Chinese People's Armed Police Forces, Tianjin 300162, China; Key 
      Laboratory of Neurotrauma Repair of Tianjin, Tianjin 300162, China.
LA  - eng
PT  - Journal Article
DEP - 20170124
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5294361
COIS- There are no actual or potential competing interests.
EDAT- 2017/03/01 06:00
MHDA- 2017/03/01 06:01
PMCR- 2017/01/24
CRDT- 2017/03/01 06:00
PHST- 2016/08/24 00:00 [received]
PHST- 2016/11/15 00:00 [revised]
PHST- 2016/11/28 00:00 [accepted]
PHST- 2017/03/01 06:00 [entrez]
PHST- 2017/03/01 06:00 [pubmed]
PHST- 2017/03/01 06:01 [medline]
PHST- 2017/01/24 00:00 [pmc-release]
AID - 10.1155/2017/8460145 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2017;2017:8460145. doi: 10.1155/2017/8460145. 
      Epub 2017 Jan 24.