PMID- 28243910
OWN - NLM
STAT- MEDLINE
DCOM- 20170315
LR  - 20170315
IS  - 1573-8221 (Electronic)
IS  - 0007-4888 (Linking)
VI  - 162
IP  - 4
DP  - 2017 Feb
TI  - Dipeptide Mimetic of the Brain-derived Neurotrophic Factor Prevents Impairments 
      of Neurogenesis in Stressed Mice.
PG  - 454-457
LID - 10.1007/s10517-017-3638-9 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) plays the central role in the mechanisms 
      of regulation of neurogenesis and neuroplasticity. Impairment of these mechanisms 
      is considered as one of the main etiological factors of depression. Dimeric 
      dipeptide mimetic of BDNF loop 4 bis-(N-monosuccinyl-l-seryl-l-lysine) 
      hexamethylenediamide (GSB-106) was synthesized at the V. V. Zakusov Research 
      Institute of Pharmacology. In vivo experiments revealed significant 
      antidepressant properties of GSB-106 in doses of 0.1-10 mg/kg (intraperitoneally 
      and orally). Effects of GSB-106 on hippocampal neurogenesis were studied in mice 
      subjected to chronic predator stress. Proliferative activity in the subgranular 
      zone of the dental gyrus was assessed immunohistochemically by Ki-67 expression 
      (a marker of dividing cells). It was found that GSB-106 (10 mg/kg, 
      intraperitoneally, 5 days) completely prevents neurogenesis disturbances in 
      stressed mice. These findings suggest that GSB-106 is a promising candidate for 
      the development of antidepressant agents with BDNF-like mechanism of action.
FAU - Gudasheva, T A
AU  - Gudasheva TA
AD  - Laboratory of Peptide Bioregulators, V. V. Zakusov Research Institute of 
      Pharmacology, Moscow, Russia. tata-sosnovka@mail.ru.
FAU - Povarnina, P Yu
AU  - Povarnina PY
AD  - Laboratory of Peptide Bioregulators, V. V. Zakusov Research Institute of 
      Pharmacology, Moscow, Russia.
FAU - Seredenin, S B
AU  - Seredenin SB
AD  - Department of Pharmacogenetics, V. V. Zakusov Research Institute of Pharmacology, 
      Moscow, Russia.
LA  - eng
PT  - Journal Article
DEP - 20170227
PL  - United States
TA  - Bull Exp Biol Med
JT  - Bulletin of experimental biology and medicine
JID - 0372557
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dipeptides)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Mki67 protein, mouse)
RN  - 0 (Peptidomimetics)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Antidepressive Agents/chemical synthesis/*pharmacology
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/chemistry
MH  - Cell Proliferation/drug effects
MH  - Dentate Gyrus/drug effects/metabolism/pathology
MH  - Depressive Disorder/*drug therapy/pathology/physiopathology
MH  - Dipeptides/chemical synthesis/*pharmacology
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression
MH  - Injections, Intraperitoneal
MH  - Ki-67 Antigen/genetics/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neurogenesis/*drug effects
MH  - Peptidomimetics/chemical synthesis/*pharmacology
MH  - Pyramidal Cells/*drug effects/metabolism/pathology
MH  - Rats, Wistar
MH  - Stress, Psychological/*drug therapy/pathology/physiopathology
OTO - NOTNLM
OT  - GCB-106
OT  - brain-derived neurotrophic factor
OT  - dipeptide mimetics
OT  - neurogenesis
OT  - stress
EDAT- 2017/03/01 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/01 06:00
PHST- 2016/02/18 00:00 [received]
PHST- 2017/03/01 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
PHST- 2017/03/01 06:00 [entrez]
AID - 10.1007/s10517-017-3638-9 [pii]
AID - 10.1007/s10517-017-3638-9 [doi]
PST - ppublish
SO  - Bull Exp Biol Med. 2017 Feb;162(4):454-457. doi: 10.1007/s10517-017-3638-9. Epub 
      2017 Feb 27.