PMID- 2824410
OWN - NLM
STAT- MEDLINE
DCOM- 19880111
LR  - 20131121
IS  - 0003-1488 (Print)
IS  - 0003-1488 (Linking)
VI  - 191
IP  - 6
DP  - 1987 Sep 15
TI  - Adrenocortical suppression by topically applied corticosteroids in healthy dogs.
PG  - 685-8
AB  - Three corticosteroid products (triamcinolone acetonide, fluocinonide, 
      betamethasone valerate) and a control product composed of water, petrolatum, 
      mineral oil, cetyl alcohol, steryl alcohol, sodium lauryl sulfate, cholesterol, 
      and methylparaben each were applied topically to healthy dogs (5 dogs/product) 
      once daily for 5 consecutive days. Plasma concentrations of immunoreactive 
      adrenocorticotropic hormone (iACTH) and cortisol were determined before 1 
      microgram of ACTH/kg of body weight was given intravenously (pre-ACTH values) and 
      cortisol was again measured 60 minutes after ACTH was given (post-ACTH values). 
      Cortisol and iACTH concentrations were determined in each dog before, during, and 
      after administration of the corticosteroid products. All 3 corticosteroids caused 
      prompt and sustained pituitary-adrenocortical suppression. Compared with control 
      applications, the application of corticosteroids resulted in significant 
      reduction of plasma cortisol and iACTH concentrations by day 2 of treatment, and 
      the lower concentrations continued to day 5. One week after the last application 
      of the corticosteroids, plasma iACTH concentrations in the corticosteroid-treated 
      dogs had returned to the range of values for the control dogs; however, pre- and 
      post-ACTH cortisol concentrations remained suppressed in all 
      corticosteroid-treated dogs. Two weeks after the last treatment, the pre-ACTH 
      plasma cortisol concentrations of corticosteroid-treated dogs returned to those 
      of the control dogs, but the post-ACTH plasma cortisol concentrations remained 
      suppressed. By 3 weeks after the last treatment, post-ACTH plasma cortisol 
      concentrations of dogs treated with triamcinolone acetonide had returned to the 
      range of values for the control dogs, but remained suppressed in the other 2 
      groups of dogs. All indices of pituitary-adrenocortical activity were within the 
      control range by 4 weeks after the last treatment.(ABSTRACT TRUNCATED AT 250 
      WORDS)
FAU - Zenoble, R D
AU  - Zenoble RD
AD  - Department of Small Animal Surgery, College of Veterinary Medicine, Auburn 
      University, AL 36849.
FAU - Kemppainen, R J
AU  - Kemppainen RJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Vet Med Assoc
JT  - Journal of the American Veterinary Medical Association
JID - 7503067
RN  - 0 (Adrenal Cortex Hormones)
RN  - 2W4A77YPAN (Fluocinonide)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9IFA5XM7R2 (Betamethasone Valerate)
RN  - F446C597KA (Triamcinolone Acetonide)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Administration, Topical
MH  - Adrenal Cortex/*drug effects/physiology
MH  - Adrenal Cortex Function Tests/veterinary
MH  - Adrenal Cortex Hormones/administration & dosage/*pharmacology
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Betamethasone Valerate/administration & dosage/pharmacology
MH  - Dogs/*physiology
MH  - Female
MH  - Fluocinonide/administration & dosage/pharmacology
MH  - Hydrocortisone/blood
MH  - Male
MH  - Pituitary-Adrenal System/*drug effects/physiology
MH  - Random Allocation
MH  - Skin Absorption
MH  - Triamcinolone Acetonide/administration & dosage/pharmacology
EDAT- 1987/09/15 00:00
MHDA- 1987/09/15 00:01
CRDT- 1987/09/15 00:00
PHST- 1987/09/15 00:00 [pubmed]
PHST- 1987/09/15 00:01 [medline]
PHST- 1987/09/15 00:00 [entrez]
PST - ppublish
SO  - J Am Vet Med Assoc. 1987 Sep 15;191(6):685-8.