PMID- 28244297
OWN - NLM
STAT- MEDLINE
DCOM- 20170523
LR  - 20221207
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 32
IP  - 4
DP  - 2017 Apr
TI  - Therapeutic Effects of Korean Red Ginseng Extract in a Murine Model of Atopic 
      Dermatitis: Anti-pruritic and Anti-inflammatory Mechanism.
PG  - 679-687
LID - 10.3346/jkms.2017.32.4.679 [doi]
AB  - Korean red ginseng (KRG) and ginsenosides exhibit diverse biological effects, 
      including anti-inflammatory and anti-allergic. We aimed to investigate the 
      therapeutic effect of KRG in a murine model of atopic dermatitis (AD) is mediated 
      whether by diminishing the pruritus or by suppressing the inflammation. Thirty 
      NC/Nga mice were randomly divided to 5 groups. AD-like skin lesions were induced 
      by percutaneous challenge with 2,4,6-trinitro-1-chrolobenzene (TNCB) on the ears 
      and backs of NC/Nga mice. KRG extract, evening primrose oil, cyclosporine, and 
      phosphate-buffered saline were administered orally by a gastric tube. Each study 
      group was also divided into scratching-permitted and scratching-restricted 
      subgroups to evaluate the impact of scratching behavior on AD. The effects of KRG 
      and the other agents were assessed by measuring the clinical severity score, ear 
      thickness, extent of transepidermal water loss (TEWL), number of scratching 
      movements, total systemic immunoglobulin E (IgE) and interleukin (IL)-31 levels, 
      histologic changes of cutaneous lesions, and mRNA expression levels of tumor 
      necrosis factor (TNF)-alpha, interferon (IFN)-gamma, thymic stromal lymphopoietin (TSLP), 
      and IL-31. KRG exerts therapeutic effects against AD by inhibiting the T helper 2 
      (Th2) mediated inflammation as well as by diminishing the itching sensation. 
      Moreover, restricting scratching behavior suppresses the vicious cycle of itching 
      and scratching, thus reducing clinical and systemic inflammation in our murine 
      model of AD.
CI  - (c) 2017 The Korean Academy of Medical Sciences.
FAU - Lee, Hyun Joo
AU  - Lee HJ
AUID- ORCID: 0000-0003-0762-8717
AD  - Department of Dermatology, The Catholic University of Korea College of Medicine, 
      Incheon St. Mary's Hospital, Incheon, Korea.
FAU - Cho, Sang Hyun
AU  - Cho SH
AUID- ORCID: 0000-0001-8289-1190
AD  - Department of Dermatology, The Catholic University of Korea College of Medicine, 
      Incheon St. Mary's Hospital, Incheon, Korea. drchosh@hotmail.com.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Cytokines)
RN  - 0 (Ginsenosides)
RN  - 0 (Interleukins)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (interleukin-31, mouse)
RN  - 059QF0KO0R (Water)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
RN  - Z4ZG7O5SZ9 (Picryl Chloride)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
SB  - IM
MH  - Animals
MH  - Asian People
MH  - Behavior, Animal/drug effects
MH  - Cytokines/genetics/metabolism
MH  - Dermatitis, Atopic/chemically induced/*drug therapy/pathology
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Ginsenosides/chemistry/pharmacology/*therapeutic use
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interferon-gamma/genetics/metabolism
MH  - Interleukins/blood/genetics/metabolism
MH  - Mice
MH  - Panax/*chemistry/metabolism
MH  - Picryl Chloride/toxicity
MH  - Plant Extracts/chemistry/*pharmacology/therapeutic use
MH  - Pruritus/drug therapy
MH  - Republic of Korea
MH  - Skin/pathology
MH  - Th2 Cells/cytology/drug effects/immunology
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
MH  - Water/metabolism
MH  - Thymic Stromal Lymphopoietin
PMC - PMC5334169
OTO - NOTNLM
OT  - Atopic
OT  - Dermatitis
OT  - Panax ginseng
OT  - Pruritus
COIS- The authors have no potential conflicts of interest to disclose.
EDAT- 2017/03/01 06:00
MHDA- 2017/05/24 06:00
PMCR- 2017/04/01
CRDT- 2017/03/01 06:00
PHST- 2016/07/04 00:00 [received]
PHST- 2016/12/04 00:00 [accepted]
PHST- 2017/03/01 06:00 [entrez]
PHST- 2017/03/01 06:00 [pubmed]
PHST- 2017/05/24 06:00 [medline]
PHST- 2017/04/01 00:00 [pmc-release]
AID - 32.679 [pii]
AID - 10.3346/jkms.2017.32.4.679 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2017 Apr;32(4):679-687. doi: 10.3346/jkms.2017.32.4.679.