PMID- 28244559
OWN - NLM
STAT- MEDLINE
DCOM- 20180327
LR  - 20180816
IS  - 2260-1341 (Print)
IS  - 2260-1341 (Linking)
VI  - 6
IP  - 1
DP  - 2017
TI  - High Versus Low Load Resistance Training: The Effect of 24 Weeks Detraining on 
      Serum Brain Derived-Neurotrophic Factor (BDNF) in Older Adults.
PG  - 53-58
LID - 10.14283/jfa.2017.2 [doi]
AB  - BACKGROUND: Previously we showed that 12 weeks of mixed-low resistance training 
      (LOW+) significantly increased circulating BDNF in older male individuals. 
      OBJECTIVES: To examine the impact of 24 weeks detraining on circulating BDNF. 
      DESIGN: Randomized intervention study. SETTING: Community-dwelling older adults. 
      PARTICIPANTS AND METHODS: Forty-seven out of 56 participants stopped training 
      (detraining) after 12 weeks of resistance exercise (3x/week) at either 
      HIGH-resistance (5 Males, 5 Females, 2x10-15 repetitions at 80%1RM), 
      LOW-resistance (6 Males, 7 Females, 1x80-100 repetitions at 20%1RM), or mixed-low 
      LOW+-resistance (6 Males, 8 Females, 1x60 repetitions at 20%1RM followed by 
      1x10-20 repetitions at 40%1RM), of whom 37 (aged 68+/-5 years) provided sufficient 
      serum samples for BDNF analysis at baseline, 12 week and at 36 weeks (24 weeks 
      detraining). RESULTS: BDNF had initially increased by 31% (from 33.4+/-10.9 ng/mL 
      to 44.5+/-13.2 ng/mL, p=0.005) after 12 weeks in the LOW+ exercise group in males 
      and decreased by 26% (from 44.5+/-13.2 ng/mL to 32.9+/-10.7 ng/mL) after detraining, 
      though not statistically significant (p=0.082). In females, no significant change 
      in BDNF was found in any of the intervention groups (p>0.05), neither after 
      training, nor detraining. At 36 weeks all of the subgroups showed BDNF levels 
      comparable (all p>0.10) to baseline (before the exercise intervention). 
      CONCLUSIONS: Our results show that a 12-weeks LOW+ resistance exercise increases 
      circulating BDNF in older male subjects but that this reduces back to baseline 
      levels after 24 weeks of detraining. Continuous exercise adherence seems to be 
      needed to sustain the training-induced effects on BDNF in older persons. 
      Additional studies are needed to unravel the underlying mechanisms, as well as to 
      confirm the observed sex difference.
FAU - Nuvagah Forti, L
AU  - Nuvagah Forti L
AD  - Prof. Dr. Ivan Bautmans, Gerontology, Vrije Universiteit Brussel, Laarbeeklaan 
      103, B-1090 Brussels, Belgium, Tel.: +3224774207; Fax: +3224776364; E-mail: 
      ivan.bautmans@vub.ac.be.
FAU - Van Roie, E
AU  - Van Roie E
FAU - Njemini, R
AU  - Njemini R
FAU - Coudyzer, W
AU  - Coudyzer W
FAU - Beyer, I
AU  - Beyer I
FAU - Delecluse, C
AU  - Delecluse C
FAU - Bautmans, I
AU  - Bautmans I
LA  - eng
SI  - ClinicalTrials.gov/NCT01707017
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - J Frailty Aging
JT  - The Journal of frailty & aging
JID - 101604797
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - *Brain-Derived Neurotrophic Factor/analysis/blood
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Independent Living
MH  - Male
MH  - Muscle Fatigue/physiology
MH  - Resistance Training/*methods
MH  - Statistics as Topic
MH  - Treatment Outcome
OTO - NOTNLM
OT  - BDNF
OT  - detraining
OT  - muscle fatigue
OT  - older adults
OT  - resistance training
OT  - training loads
COIS- None of the authors have any conflict of interest with any entity with regard to 
      this study.
EDAT- 2017/03/01 06:00
MHDA- 2018/03/28 06:00
CRDT- 2017/03/01 06:00
PHST- 2017/03/01 06:00 [entrez]
PHST- 2017/03/01 06:00 [pubmed]
PHST- 2018/03/28 06:00 [medline]
AID - 10.14283/jfa.2017.2 [doi]
PST - ppublish
SO  - J Frailty Aging. 2017;6(1):53-58. doi: 10.14283/jfa.2017.2.