PMID- 28245614
OWN - NLM
STAT- MEDLINE
DCOM- 20170420
LR  - 20240324
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 18
IP  - 3
DP  - 2017 Feb 25
TI  - Gene Expression in Osteolysis: Review on the Identification of Altered Molecular 
      Pathways in Preclinical and Clinical Studies.
LID - 10.3390/ijms18030499 [doi]
LID - 499
AB  - Aseptic loosening (AL) due to osteolysis is the primary cause of joint prosthesis 
      failure. Currently, a second surgery is still the only available treatment for 
      AL, with its associated drawbacks. The present review aims at identifying genes 
      whose expression is altered in osteolysis, and that could be the target of new 
      pharmacological treatments, with the goal of replacing surgery. This review also 
      aims at identifying the molecular pathways altered by different wear particles. 
      We reviewed preclinical and clinical studies from 2010 to 2016, analyzing gene 
      expression of tissues or cells affected by osteolysis. A total of 32 in vitro, 16 
      in vivo and six clinical studies were included. These studies revealed that genes 
      belonging to both inflammation and osteoclastogenesis pathways are mainly 
      involved in osteolysis. More precisely, an increase in genes encoding for the 
      following factors were observed: Interleukins 6 and 1beta (IL16 and beta), Tumor 
      Necrosis Factor alpha (TNFalpha), nuclear factor kappa-light-chain-enhancer of activated 
      B cells (NFkappaB), Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), 
      Cathepsin K (CATK) and Tartrate-resistant acid phosphatase (TRAP). Titanium (Ti) 
      and Polyethylene (PE) were the most studied particles, showing that Ti 
      up-regulated inflammation and osteoclastogenesis related genes, while PE 
      up-regulated primarily osteoclastogenesis related genes.
FAU - Veronesi, Francesca
AU  - Veronesi F
AD  - Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, via 
      di Barbiano 1/10, 40136 Bologna, Italy. francesca.veronesi@ior.it.
FAU - Tschon, Matilde
AU  - Tschon M
AD  - Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, via 
      di Barbiano 1/10, 40136 Bologna, Italy. matilde.tschon@ior.it.
FAU - Fini, Milena
AU  - Fini M
AD  - Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, via 
      di Barbiano 1/10, 40136 Bologna, Italy. milena.fini@ior.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170225
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Animals
MH  - Clinical Studies as Topic
MH  - Disease Models, Animal
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Inflammation/genetics/metabolism/pathology
MH  - Osteoclasts/metabolism
MH  - Osteolysis/*genetics/*metabolism
MH  - *Signal Transduction
PMC - PMC5372515
OTO - NOTNLM
OT  - aseptic loosening
OT  - gene expression
OT  - genomics
OT  - inflammation
OT  - osteoclastogenesis
OT  - osteolysis
COIS- The authors declare no conflict of interest.
EDAT- 2017/03/02 06:00
MHDA- 2017/04/21 06:00
PMCR- 2017/03/01
CRDT- 2017/03/02 06:00
PHST- 2017/01/19 00:00 [received]
PHST- 2017/02/20 00:00 [revised]
PHST- 2017/02/21 00:00 [accepted]
PHST- 2017/03/02 06:00 [entrez]
PHST- 2017/03/02 06:00 [pubmed]
PHST- 2017/04/21 06:00 [medline]
PHST- 2017/03/01 00:00 [pmc-release]
AID - ijms18030499 [pii]
AID - ijms-18-00499 [pii]
AID - 10.3390/ijms18030499 [doi]
PST - epublish
SO  - Int J Mol Sci. 2017 Feb 25;18(3):499. doi: 10.3390/ijms18030499.