PMID- 28247313
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20231005
IS  - 1573-2649 (Electronic)
IS  - 0962-9343 (Print)
IS  - 0962-9343 (Linking)
VI  - 26
IP  - 7
DP  - 2017 Jul
TI  - Electronic patient-reported outcomes and toxicities during radiotherapy for 
      head-and-neck cancer.
PG  - 1721-1731
LID - 10.1007/s11136-017-1528-2 [doi]
AB  - PURPOSE: To characterize quality of life (QOL) using real-time, electronic 
      patient-reported outcomes (ePROs) and to evaluate adverse events (AEs) and 
      supportive care during head-and-neck radiotherapy (RT) and concurrent 
      chemoradiotherapy (CCRT). METHODS: Sixty-five patients undergoing head-and-neck 
      RT completed electronic, real-time, 12-item linear analog self-assessments (LASA) 
      at baseline, before biweekly appointments, and at the last week of RT. Changes in 
      QOL domains between time points were calculated. Clinical data were collected 
      from the institutional medical record. AEs were recorded at the same time points 
      as the LASA and graded. RESULTS: During head-and-neck RT, most patients had 
      clinically meaningful decreases in all QOL domains except level of support, 
      financial concerns, and legal concerns. QOL domains with the most prevalent, 
      clinically meaningful decreases were fatigue (75.4% of patients; 95% CI, 
      62.9-84.9%), social activity (70.8%; 95% CI, 58.0-81.1%), and overall QOL (70.8%; 
      95% CI, 58.0-81.1%). All patients had grade 2 AEs; 35.4% had grade 3 (50.0%, 
      CCRT; 12.0%, RT; P = .002). Weight loss averaged 5.5 kg (6.9 kg, CCRT; 2.8 kg, 
      RT; P < .001). Intravenous hydration was needed in 52.3% (77.5%, CCRT; 12.0%, RT; 
      P < .001); feeding tube placement 40.0% (57.5%, CCRT; 12.0%, RT; P = .001); 
      emergency department visits without hospitalization, 10.8%; and emergent 
      hospitalization, 27.7% (37.5%, CCRT; 12.0%, RT; P = .04). CONCLUSIONS: 
      Head-and-neck RT, particularly CCRT, negatively impacts patients' overall QOL, 
      social activity, and fatigue, with frequent grade 3 AEs, weight loss, intravenous 
      hydration, feeding tube placement, ED visits, and hospitalization. Real-time 
      ePROs allow providers to monitor QOL at multiple time points during RT, 
      potentially allowing early intervention to improve QOL and mitigate AEs.
FAU - Niska, Joshua R
AU  - Niska JR
AD  - Department of Radiation Oncology, Mayo Clinic Hospital, 5777 E Mayo Blvd, 
      Phoenix, AZ, 85054, USA.
FAU - Halyard, Michele Y
AU  - Halyard MY
AD  - Department of Radiation Oncology, Mayo Clinic Hospital, 5777 E Mayo Blvd, 
      Phoenix, AZ, 85054, USA. mhalyard@mayo.edu.
FAU - Tan, Angelina D
AU  - Tan AD
AD  - Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 
      USA.
FAU - Atherton, Pamela J
AU  - Atherton PJ
AD  - Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 
      USA.
FAU - Patel, Samir H
AU  - Patel SH
AD  - Department of Radiation Oncology, Mayo Clinic Hospital, 5777 E Mayo Blvd, 
      Phoenix, AZ, 85054, USA.
FAU - Sloan, Jeff A
AU  - Sloan JA
AD  - Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 
      USA.
LA  - eng
GR  - P30 CA015083/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20170228
PL  - Netherlands
TA  - Qual Life Res
JT  - Quality of life research : an international journal of quality of life aspects of 
      treatment, care and rehabilitation
JID - 9210257
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Head and Neck Neoplasms/complications/*radiotherapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Patient Reported Outcome Measures
MH  - Quality of Life/*psychology
MH  - Radiotherapy/*adverse effects
PMC - PMC6301021
MID - NIHMS903309
OTO - NOTNLM
OT  - Adverse events
OT  - Head-and-neck cancer
OT  - Patient-reported outcomes
OT  - Quality of life
OT  - Radiation
OT  - Toxicity
COIS- Conflict of Interest: The authors declare that they have no conflict of interest.
EDAT- 2017/03/02 06:00
MHDA- 2018/01/09 06:00
PMCR- 2018/12/19
CRDT- 2017/03/02 06:00
PHST- 2017/02/13 00:00 [accepted]
PHST- 2017/03/02 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
PHST- 2017/03/02 06:00 [entrez]
PHST- 2018/12/19 00:00 [pmc-release]
AID - 10.1007/s11136-017-1528-2 [pii]
AID - 10.1007/s11136-017-1528-2 [doi]
PST - ppublish
SO  - Qual Life Res. 2017 Jul;26(7):1721-1731. doi: 10.1007/s11136-017-1528-2. Epub 
      2017 Feb 28.