PMID- 28248600
OWN - NLM
STAT- MEDLINE
DCOM- 20170731
LR  - 20181231
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 156
IP  - 3
DP  - 2017 Mar
TI  - Mitochondria-Targeted Antioxidant Mitoquinone Reduces Cisplatin-Induced 
      Ototoxicity in Guinea Pigs.
PG  - 543-548
LID - 10.1177/0194599816678381 [doi]
AB  - Objective To determine if mitoquinone (MitoQ) attenuates cisplatin-induced 
      hearing loss in guinea pigs. Study Design Prospective and controlled animal 
      study. Setting Academic, tertiary medical center. Subjects and Methods Guinea 
      pigs were injected subcutaneously with either 5 mg/kg MitoQ (n = 9) or normal 
      saline (control, n = 9) for 7 days and 1 hour before receiving a single dose of 
      10 mg/kg cisplatin. Auditory brainstem response thresholds were measured before 
      MitoQ or saline administration and 3 to 4 days after cisplatin administration. 
      Results Auditory brainstem response threshold shifts after cisplatin treatment 
      were smaller by 28 to 47 dB in guinea pigs injected with MitoQ compared with 
      those in the control group at all tested frequencies (4, 8, 16, and 24 kHz, P = 
      .0002 to .04). Scanning electron microscopy of cochlear hair cells showed less 
      outer hair cell loss and damage in the MitoQ group. Conclusion MitoQ reduced 
      cisplatin-induced hearing loss in guinea pigs. MitoQ appears worthy of further 
      investigation as a means of preventing cisplatin ototoxicity in humans.
FAU - Tate, Alan D
AU  - Tate AD
AD  - 1 Department of Otolaryngology-Head and Neck Surgery, University of Florida, 
      Gainesville, Florida, USA.
FAU - Antonelli, Patrick J
AU  - Antonelli PJ
AD  - 1 Department of Otolaryngology-Head and Neck Surgery, University of Florida, 
      Gainesville, Florida, USA.
FAU - Hannabass, Kyle R
AU  - Hannabass KR
AD  - 2 University of California Los Angeles Medical Center, Los Angeles, California, 
      USA.
FAU - Dirain, Carolyn O
AU  - Dirain CO
AD  - 1 Department of Otolaryngology-Head and Neck Surgery, University of Florida, 
      Gainesville, Florida, USA.
LA  - eng
GR  - R03 DC013659/DC/NIDCD NIH HHS/United States
PT  - Journal Article
DEP - 20161116
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Organophosphorus Compounds)
RN  - 1339-63-5 (Ubiquinone)
RN  - 47BYS17IY0 (mitoquinone)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*toxicity
MH  - Antioxidants/*therapeutic use
MH  - Cisplatin/*toxicity
MH  - Guinea Pigs
MH  - Hearing Loss/*chemically induced/*prevention & control
MH  - Male
MH  - Mitochondria/drug effects
MH  - Organophosphorus Compounds/pharmacology/*therapeutic use
MH  - Ubiquinone/*analogs & derivatives/pharmacology/therapeutic use
OTO - NOTNLM
OT  - cisplatin
OT  - guinea pigs
OT  - hearing loss
OT  - mitoquinone
OT  - ototoxicity
EDAT- 2017/03/02 06:00
MHDA- 2017/08/02 06:00
CRDT- 2017/03/02 06:00
PHST- 2017/03/02 06:00 [entrez]
PHST- 2017/03/02 06:00 [pubmed]
PHST- 2017/08/02 06:00 [medline]
AID - 10.1177/0194599816678381 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2017 Mar;156(3):543-548. doi: 
      10.1177/0194599816678381. Epub 2016 Nov 16.