PMID- 28249245
OWN - NLM
STAT- MEDLINE
DCOM- 20180220
LR  - 20180220
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 89
DP  - 2017 May
TI  - Pharmacological evaluation of aqueous extract of syzigium cumini for its 
      antihyperglycemic and antidyslipidemic properties in diabetic rats fed a high 
      cholesterol diet-Role of PPARgamma and PPARalpha.
PG  - 447-453
LID - S0753-3322(16)32522-7 [pii]
LID - 10.1016/j.biopha.2017.02.048 [doi]
AB  - In India syzygium cumini (Myrtaceae) is commonly used traditional medicine to 
      treat diabetes. The present study was undertaken to assess an investigation of 
      antihyperglycemic and antidyslipidemic properties of aqueous extract of Syzigium 
      Cumini (SC) in diabetic rats fed a high cholesterol diet. The aqueous extract of 
      SC was screened for antihyperglycemic and antidyslipidemic activity by 
      streptozotocin induced diabetes in rats. Animals were treated with 100, 200 and 
      400mg/kg body weight of aqueous extract of SC. Metformin were used as reference 
      antihyperglycemic drugs for comparison. Administration of aqueous extract of SC 
      or metformin for 21days resulted in a significant (P<0.05) reduction in serum 
      glucose, insulin and Homeostasis model assessment of insulin resistance (HOMA-IR) 
      compared with diabetic controls. Treatment with 100mg/kg/day aqueous extract of 
      SC did not result in a significant reduction in serum insulin levels, but 
      200mg/kg/day and 400mg/kg/day, aqueous extract of SC and metformin showed 
      significant reductions 17.89%, 19.60% and 24.40%, respectively. Furthermore, 
      administration of 100, 200 and 400mg/kg/day, aqueous extract of SC and metformin 
      resulted in significant decrease in insulin resistance of 19.20%, 41.59%, 51.55% 
      and 68.68%, respectively. In high fat diet- streptozotocin (HFD - STZ) treated 
      rats beta-cells function (HOMA-B) were markedly reduced (5.8-fold), however observed 
      a significant (P<0.01) improvement of beta-cell function with aqueous extract of SC 
      (400mg/kg/day) and metformin. The aqueous extract of SC seeds exhibits 
      significant insulin-sensitizing, antidyslipidemic, antioxidant, anti-inflammatory 
      and beta-cell salvaging activity in HFD-STZ-induced type 2 diabetic rats via 
      overexpression of PPARgamma and PPARalpha activity, affirming its potential to be used in 
      the prevention and treatment of type 2 diabetes mellitus (T2DM). Further 
      isolation and characterization of active components in SC seed extract are needed 
      to explore the other possible mechanisms and pathways that are involved in its 
      anti-diabetic effect.
CI  - Copyright (c) 2017 Elsevier Masson SAS. All rights reserved.
FAU - Sharma, Sandhya
AU  - Sharma S
AD  - Sunder Deep Pharmacy College, Ghaziabad, Uttar Pradesh, 201001, India.
FAU - Pathak, Sachchidanand
AU  - Pathak S
AD  - School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura 302017, 
      Jaipur, India.
FAU - Gupta, Gaurav
AU  - Gupta G
AD  - School of Pharmacy, Jaipur National University, Delhi-Agra bypass, Jagatpura 
      302017, Jaipur, India; School of Medicine and Public Health, University of 
      Newcastle, Newcastle, NSW 2308, Australia. Electronic address: 
      gauravpharma25@gmail.com.
FAU - Sharma, Satish Kumar
AU  - Sharma SK
AD  - Sunder Deep Pharmacy College, Ghaziabad, Uttar Pradesh, 201001, India.
FAU - Singh, Lalit
AU  - Singh L
AD  - Sunder Deep Pharmacy College, Ghaziabad, Uttar Pradesh, 201001, India.
FAU - Sharma, Rakesh Kumar
AU  - Sharma RK
AD  - School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura 302017, 
      Jaipur, India.
FAU - Mishra, Anurag
AU  - Mishra A
AD  - School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura 302017, 
      Jaipur, India.
FAU - Dua, Kamal
AU  - Dua K
AD  - Discipline of Pharmacy, Graduate School of Health, University of Technology 
      Sydney, Sydney, NSW 2007, Australia; School of Biomedical Sciences and Pharmacy, 
      University of Newcastle, Newcastle, NSW 2308, Australia; School of Pharmaceutical 
      Sciences, Shoolini University, Solan, Himachal Pradesh, 173229, India.
LA  - eng
PT  - Journal Article
DEP - 20170227
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, Dietary)
RN  - 0 (Dietary Fats)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Hypolipidemic Agents)
RN  - 0 (Insulin)
RN  - 0 (PPAR alpha)
RN  - 0 (PPAR gamma)
RN  - 0 (Plant Extracts)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Animal Feed
MH  - Animals
MH  - Blood Glucose/drug effects
MH  - Cholesterol, Dietary/administration & dosage
MH  - Diabetes Mellitus, Experimental/drug therapy
MH  - Dietary Fats/administration & dosage
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression Regulation/drug effects
MH  - Hypoglycemic Agents/chemistry/*pharmacology
MH  - Hypolipidemic Agents/chemistry/*pharmacology
MH  - Insulin/blood/metabolism
MH  - Male
MH  - Metformin/pharmacology
MH  - PPAR alpha/*metabolism
MH  - PPAR gamma/*metabolism
MH  - Plant Extracts/administration & dosage/chemistry/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Syzygium/*chemistry
OTO - NOTNLM
OT  - Antidiabetic
OT  - Antidyslipidemic
OT  - Metformin
OT  - Streptozotocin
OT  - Syzigium cumini
EDAT- 2017/03/02 06:00
MHDA- 2018/02/21 06:00
CRDT- 2017/03/02 06:00
PHST- 2016/11/28 00:00 [received]
PHST- 2017/02/15 00:00 [revised]
PHST- 2017/02/15 00:00 [accepted]
PHST- 2017/03/02 06:00 [pubmed]
PHST- 2018/02/21 06:00 [medline]
PHST- 2017/03/02 06:00 [entrez]
AID - S0753-3322(16)32522-7 [pii]
AID - 10.1016/j.biopha.2017.02.048 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2017 May;89:447-453. doi: 10.1016/j.biopha.2017.02.048. Epub 
      2017 Feb 27.