PMID- 28249577 OWN - NLM STAT- MEDLINE DCOM- 20171003 LR - 20220409 IS - 1475-2840 (Electronic) IS - 1475-2840 (Linking) VI - 16 IP - 1 DP - 2017 Mar 1 TI - Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study. PG - 30 LID - 10.1186/s12933-017-0514-x [doi] LID - 30 AB - BACKGROUND: Risk of type 2 diabetes mellitus (T2DM) is increased in metabolically obese but normal-weight people. However, we have limited knowledge of how to prevent T2DM in normal-weight people. We aimed to evaluate the association between triglyceride glucose (TyG) index and incident T2DM among normal-weight people in rural China. METHODS: We included data from 5706 people with normal body mass index (BMI) (18.5-23.9 kg/m(2)) without baseline T2DM in a rural Chinese cohort followed for a median of 6.0 years. A Cox proportional-hazard model was used to assess the risk of incident T2DM by quartiles of TyG index and difference in TyG index between follow-up and baseline (TyG-D), estimating hazard ratios (HRs) and 95% confidence intervals (CIs). A generalized additive plot was used to show the nonparametric smoothed exposure-response association between risk of T2DM and TyG index as a continuous variable. TyG was calculated as ln [fasting triglyceride level (mg/dl) x fasting plasma glucose level (mg/dl)/2]. RESULTS: Risk of incident T2DM was increased with quartiles 2, 3 and 4 versus quartile 1 of TyG index (adjusted HR [aHR] 2.48 [95% CI 1.20-5.11], 3.77 [1.83-7.79], and 5.30 [2.21-12.71], P (trend) < 0.001 across quartiles of TyG index). Risk of incident T2DM was increased with quartile 4 versus quartile 1 of TyG-D (aHR 3.91 [2.22-6.87]). The results were consistent when analyses were restricted to participants without baseline metabolic syndrome and impaired fasting glucose level. The generalized additive plot showed cumulative increased risk of T2DM with increasing TyG index. CONCLUSIONS: Risk of incident T2DM is increased with increasing TyG index among rural Chinese people, so the index might be an important indicator for identifying people at high risk of T2DM. FAU - Zhang, Ming AU - Zhang M AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Nanshan District, Shenzhen, 518060, Guangdong, People's Republic of China. FAU - Wang, Bingyuan AU - Wang B AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Nanshan District, Shenzhen, 518060, Guangdong, People's Republic of China. AD - The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Liu, Yu AU - Liu Y AD - The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Sun, Xizhuo AU - Sun X AD - The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Luo, Xinping AU - Luo X AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Nanshan District, Shenzhen, 518060, Guangdong, People's Republic of China. FAU - Wang, Chongjian AU - Wang C AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Li, Linlin AU - Li L AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Zhang, Lu AU - Zhang L AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Nanshan District, Shenzhen, 518060, Guangdong, People's Republic of China. AD - The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Ren, Yongcheng AU - Ren Y AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Nanshan District, Shenzhen, 518060, Guangdong, People's Republic of China. AD - The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Zhao, Yang AU - Zhao Y AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Nanshan District, Shenzhen, 518060, Guangdong, People's Republic of China. AD - The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Zhou, Junmei AU - Zhou J AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Nanshan District, Shenzhen, 518060, Guangdong, People's Republic of China. AD - The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Han, Chengyi AU - Han C AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Nanshan District, Shenzhen, 518060, Guangdong, People's Republic of China. AD - The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Zhao, Jingzhi AU - Zhao J AD - Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, Henan, People's Republic of China. FAU - Hu, Dongsheng AU - Hu D AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, 3688 Nanhai Avenue, Nanshan District, Shenzhen, 518060, Guangdong, People's Republic of China. hud@szu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20170301 PL - England TA - Cardiovasc Diabetol JT - Cardiovascular diabetology JID - 101147637 RN - 0 (Blood Glucose) RN - 0 (Triglycerides) SB - IM MH - Adult MH - Blood Glucose/*metabolism MH - *Body Mass Index MH - Body Weight/*physiology MH - China/ethnology MH - Cohort Studies MH - Diabetes Mellitus, Type 2/*blood/diagnosis/ethnology MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Middle Aged MH - Prospective Studies MH - Risk Factors MH - *Rural Population MH - Triglycerides/*blood PMC - PMC5333419 OTO - NOTNLM OT - Cohort study OT - Insulin resistance OT - Normal weight OT - Triglyceride glucose index OT - Type 2 diabetes mellitus EDAT- 2017/03/03 06:00 MHDA- 2017/10/04 06:00 PMCR- 2017/03/01 CRDT- 2017/03/03 06:00 PHST- 2016/12/18 00:00 [received] PHST- 2017/02/22 00:00 [accepted] PHST- 2017/03/03 06:00 [entrez] PHST- 2017/03/03 06:00 [pubmed] PHST- 2017/10/04 06:00 [medline] PHST- 2017/03/01 00:00 [pmc-release] AID - 10.1186/s12933-017-0514-x [pii] AID - 514 [pii] AID - 10.1186/s12933-017-0514-x [doi] PST - epublish SO - Cardiovasc Diabetol. 2017 Mar 1;16(1):30. doi: 10.1186/s12933-017-0514-x.