PMID- 2825052
OWN - NLM
STAT- MEDLINE
DCOM- 19871218
LR  - 20190820
IS  - 0364-3190 (Print)
IS  - 0364-3190 (Linking)
VI  - 11
IP  - 11
DP  - 1986 Nov
TI  - Functional and biochemical characteristics of a putative quisqualate-type 
      receptor in rat striatum: effect of brain lesions.
PG  - 1533-45
AB  - Excitatory amino acids such as L-glutamate (Glu) and quisqualate (QUIS) markedly 
      potentiated K+-evoked release of exogenous [3H]dopamine (DA) from rat striatal 
      slices. Intrastriatal kainic acid injections resulted in a total disappearance of 
      the stimulatory effects of Glu on evoked-release of [3H]DA as well as in a 
      parallel reduction in the maximal number (Bmax) of a D-aspartate-insensitive 
      L-[3H]Glu binding site in striatal particulate fractions. Following cortical 
      ablation, the potentiating effect of Glu on [3H]DA release in decorticated 
      striatal slices lasted longer, compared to normal slices, and occurred during the 
      2nd min following K+-depolarization. However, the extent (%) of Glu stimulation 
      on [3H]DA release remained the same in decorticated and normal striatal slices. 
      Cortical ablation produced also a significant decrease in the Bmax and in the KD' 
      of the D-aspartate-insensitive binding site towards L-[3H]Glu. These results 
      support the proposal that the D-aspartate-insensitive Glu binding site is somehow 
      related to an amino acid receptor-mediated modulation of dopaminergic 
      transmission in the rat corpus striatum.
FAU - Rudolph, M I
AU  - Rudolph MI
AD  - Department of Cell Biology, Pontificia Universidad Catolica de Chile, Santiago.
FAU - Bustos, G
AU  - Bustos G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Convulsants)
RN  - 0 (Glutamates)
RN  - 0 (Oxadiazoles)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, Drug)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - RWP5GA015D (Potassium)
RN  - SIV03811UC (Kainic Acid)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Aspartic Acid/analogs & derivatives/pharmacology
MH  - Brain/*physiology
MH  - Cerebral Cortex/physiology
MH  - Convulsants/pharmacology
MH  - Corpus Striatum/drug effects/*physiology
MH  - Dopamine/metabolism
MH  - Glutamates/pharmacology
MH  - In Vitro Techniques
MH  - Kainic Acid/pharmacology
MH  - Male
MH  - N-Methylaspartate
MH  - Oxadiazoles/metabolism/*pharmacology
MH  - Potassium/pharmacology
MH  - Quisqualic Acid
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, AMPA
MH  - Receptors, Drug/drug effects/*physiology
EDAT- 1986/11/01 00:00
MHDA- 1986/11/01 00:01
CRDT- 1986/11/01 00:00
PHST- 1986/11/01 00:00 [pubmed]
PHST- 1986/11/01 00:01 [medline]
PHST- 1986/11/01 00:00 [entrez]
AID - 10.1007/BF00965772 [doi]
PST - ppublish
SO  - Neurochem Res. 1986 Nov;11(11):1533-45. doi: 10.1007/BF00965772.