PMID- 28250730
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1673-5374 (Print)
IS  - 1876-7958 (Electronic)
IS  - 1673-5374 (Linking)
VI  - 12
IP  - 1
DP  - 2017 Jan
TI  - Therapeutic potential of brain-derived neurotrophic factor (BDNF) and a small 
      molecular mimics of BDNF for traumatic brain injury.
PG  - 7-12
LID - 10.4103/1673-5374.198964 [doi]
AB  - Traumatic brain injury (TBI) is a major health problem worldwide. Following 
      primary mechanical insults, a cascade of secondary injuries often leads to 
      further neural tissue loss. Thus far there is no cure to rescue the damaged 
      neural tissue. Current therapeutic strategies primarily target the secondary 
      injuries focusing on neuroprotection and neuroregeneration. The neurotrophin 
      brain-derived neurotrophic factor (BDNF) has significant effect in both aspects, 
      promoting neuronal survival, synaptic plasticity and neurogenesis. Recently, the 
      flavonoid 7,8-dihydroxyflavone (7,8-DHF), a small TrkB agonist that mimics BDNF 
      function, has shown similar effects as BDNF in promoting neuronal survival and 
      regeneration following TBI. Compared to BDNF, 7,8-DHF has a longer half-life and 
      much smaller molecular size, capable of penetrating the blood-brain barrier, 
      which makes it possible for non-invasive clinical application. In this review, we 
      summarize functions of the BDNF/TrkB signaling pathway and studies examining the 
      potential of BDNF and 7,8-DHF as a therapy for TBI.
FAU - Wurzelmann, Mary
AU  - Wurzelmann M
AD  - Department of Neurosurgery, School of Medicine, Virginia Commonwealth University, 
      Richmond, VA, USA.
FAU - Romeika, Jennifer
AU  - Romeika J
AD  - Department of Neurosurgery, School of Medicine, Virginia Commonwealth University, 
      Richmond, VA, USA.
FAU - Sun, Dong
AU  - Sun D
AUID- ORCID: 0000-0002-3837-7319
AD  - Department of Neurosurgery, School of Medicine, Virginia Commonwealth University, 
      Richmond, VA, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Neural Regen Res
JT  - Neural regeneration research
JID - 101316351
PMC - PMC5319242
OTO - NOTNLM
OT  - 7,8-dihydroxyflavone
OT  - brain-derived neurotrophic factor
OT  - neuroprotection
OT  - neuroregeneration
OT  - traumatic brain injury
OT  - tropomyosin related kinase B (TrkB) receptor
COIS- Conflicts of interest: None declared.
EDAT- 2017/03/03 06:00
MHDA- 2017/03/03 06:01
PMCR- 2017/01/01
CRDT- 2017/03/03 06:00
PHST- 2017/03/03 06:00 [entrez]
PHST- 2017/03/03 06:00 [pubmed]
PHST- 2017/03/03 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - NRR-12-7 [pii]
AID - 10.4103/1673-5374.198964 [doi]
PST - ppublish
SO  - Neural Regen Res. 2017 Jan;12(1):7-12. doi: 10.4103/1673-5374.198964.