PMID- 28252625
OWN - NLM
STAT- MEDLINE
DCOM- 20170606
LR  - 20181023
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 89
IP  - 1
DP  - 2017
TI  - [Light-chain deposition disease is a hematologic problem].
PG  - 38-42
LID - 10.17116/terarkh201789138-42 [doi]
AB  - AIM: To analyze clinical and laboratory data and treatment results in patients 
      with light-chain deposition disease (LCDD). SUBJECTS AND METHODS: Nine patients 
      with LCDD and kidney injury were examined. The diagnosis was based on the results 
      of light and immunofluorescence microscopy of renal biopsy specimens. All the 
      patients received bortezomib, cyclophosphamide, and dexamethasone (VCD) induction 
      therapy. RESULTS: Six patients were diagnosed with multiple myeloma; in 3 
      patients LCDD was considered within monoclonal gammopathy manly involving the 
      kidney. By the initiation of therapy, all the patients were diagnosed as having 
      chronic kidney disease (Stage III (n=2), Stage IV (n=2), and dialysis-related 
      renal failure (n=5)). After the VCD treatment, 7 of 9 patients achieved a 
      hematologic response. Second-line therapy with lenalidomide proved to be 
      effective in the other 2 cases. Five patients achieved complete remission; 3 had 
      a very good partial remission. Thereafter, 2 patients received high-dose 
      melphalan chemotherapy and autologous hematopoietic stem cell transplantation. 
      Better renal function was noted in only 2 cases. CONCLUSION: Despite the high 
      efficiency of therapy aimed to reduce monoclonal light chains; improved renal 
      function was observed in only 2 (22%) patients. Such low rates of a renal 
      response were due to the late initiation of therapy.
FAU - Rekhtina, I G
AU  - Rekhtina IG
AD  - National Research Center for Hematology, Ministry of Health of Russia, Moscow, 
      Russia.
FAU - Mendeleeva, L P
AU  - Mendeleeva LP
AD  - National Research Center for Hematology, Ministry of Health of Russia, Moscow, 
      Russia.
FAU - Biryukova, L S
AU  - Biryukova LS
AD  - National Research Center for Hematology, Ministry of Health of Russia, Moscow, 
      Russia.
LA  - rus
PT  - Journal Article
TT  - Bolezn' depozitov legkikh tsepei - gematologicheskaia problema.
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
SB  - IM
MH  - Aged
MH  - Female
MH  - Hematologic Diseases/complications/*diagnosis/drug therapy
MH  - Humans
MH  - Immunoproliferative Disorders/complications/*diagnosis/drug therapy
MH  - Male
MH  - Middle Aged
MH  - *Plasma Cells
MH  - Renal Insufficiency, Chronic/*diagnosis/etiology
EDAT- 2017/03/03 06:00
MHDA- 2017/06/07 06:00
CRDT- 2017/03/03 06:00
PHST- 2017/03/03 06:00 [entrez]
PHST- 2017/03/03 06:00 [pubmed]
PHST- 2017/06/07 06:00 [medline]
AID - 10.17116/terarkh201789138-42 [doi]
PST - ppublish
SO  - Ter Arkh. 2017;89(1):38-42. doi: 10.17116/terarkh201789138-42.