PMID- 28253291 OWN - NLM STAT- MEDLINE DCOM- 20170912 LR - 20190208 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 12 IP - 3 DP - 2017 TI - Stable self-serving personality traits in recreational and dependent cocaine users. PG - e0172853 LID - 10.1371/journal.pone.0172853 [doi] LID - e0172853 AB - Chronic cocaine use has been associated with impairments in social cognition, self-serving and antisocial behavior, and socially relevant personality disorders (PD). Despite the apparent relationship between Machiavellianism and stimulant use, no study has explicitly examined this personality concept in cocaine users so far. In the frame of the longitudinal Zurich Cocaine Cognition Study, the Machiavellianism Questionnaire (MACH-IV) was assessed in 68 recreational and 30 dependent cocaine users as well as in 68 psychostimulant-naive controls at baseline. Additionally, three closely related personality dimensions from the Temperament and Character Inventory (TCI)-cooperativeness, (social) reward dependence, and self-directedness-and the screening questionnaire of the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II) were acquired. At the one-year follow-up, 57 cocaine users and 48 controls were reassessed with the MACH-IV. Finally, MACH-IV scores were correlated with measures of social cognition and interaction (cognitive/emotional empathy, Theory-of-Mind, prosocial behavior) and with SCID-II PD scores assessed at baseline. Both recreational and dependent cocaine users showed significantly higher Machiavellianism than controls, while dependent cocaine users additionally displayed significantly lower levels of TCI cooperativeness and self-directedness. During the one-year interval, MACH-IV scores showed high test-retest reliability and also the significant gap between cocaine users and controls remained. Moreover, in cocaine users, higher Machiavellianism correlated significantly with lower levels of cooperativeness and self-directedness, with less prosocial behavior, and with higher cluster B PD scores. However, Machiavellianism was not correlated with measures of cocaine use severity (r<-.15). Both recreational and dependent cocaine users display pronounced and stable Machiavellian personality traits. The lack of correlations with severity of cocaine use and its temporal stability indicates that a Machiavellian personality trait might represent a predisposition for cocaine use that potentially serves as a predictor for stimulant addiction. FAU - Quednow, Boris B AU - Quednow BB AD - Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland. FAU - Hulka, Lea M AU - Hulka LM AD - Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland. FAU - Preller, Katrin H AU - Preller KH AD - Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland. FAU - Baumgartner, Markus R AU - Baumgartner MR AD - Zurich Institute of Forensic Medicine, Center for Forensic Hair Analysis, University of Zurich, Zurich, Switzerland. FAU - Eisenegger, Christoph AU - Eisenegger C AD - Neuropsychopharmacology and Biopsychology Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna, Austria. FAU - Vonmoos, Matthias AU - Vonmoos M AD - Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland. LA - eng PT - Journal Article DEP - 20170302 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adult MH - Cocaine-Related Disorders/*psychology MH - Female MH - Humans MH - Male MH - *Personality MH - Young Adult PMC - PMC5333846 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2017/03/03 06:00 MHDA- 2017/09/13 06:00 PMCR- 2017/03/02 CRDT- 2017/03/03 06:00 PHST- 2016/08/24 00:00 [received] PHST- 2017/02/10 00:00 [accepted] PHST- 2017/03/03 06:00 [entrez] PHST- 2017/03/03 06:00 [pubmed] PHST- 2017/09/13 06:00 [medline] PHST- 2017/03/02 00:00 [pmc-release] AID - PONE-D-16-33892 [pii] AID - 10.1371/journal.pone.0172853 [doi] PST - epublish SO - PLoS One. 2017 Mar 2;12(3):e0172853. doi: 10.1371/journal.pone.0172853. eCollection 2017.