PMID- 28253896
OWN - NLM
STAT- MEDLINE
DCOM- 20170522
LR  - 20220317
IS  - 1749-799X (Electronic)
IS  - 1749-799X (Linking)
VI  - 12
IP  - 1
DP  - 2017 Mar 3
TI  - Evaluation of Singh Index and Osteoporosis Self-Assessment Tool for Asians as 
      risk assessment tools of hip fracture in patients with type 2 diabetes mellitus.
PG  - 37
LID - 10.1186/s13018-017-0539-6 [doi]
LID - 37
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM), an epidemic disease around world, 
      has recently been identified as a risk factor for osteoporosis-associated 
      fracture. However, there is no consensus on the best method of assessing fracture 
      risk in patients with T2DM. The aim of this study was to evaluate the usefulness 
      of the Osteoporosis Self-Assessment Tool for Asians (OSTA) and the Singh Index 
      (SI) in hip fracture risk assessment in patients with T2DM. METHODS: We enrolled 
      261 postmenopausal women with T2DM: 87 had hip fracture resulting from low-energy 
      trauma and 174 age-matched controls had no fracture (two controls per fracture 
      case). Bone mineral density (BMD) was measured with dual-energy X-ray 
      absorptiometry in the lumbar spine and hip region. The SI was obtained from 
      standard antero-posterior radiographs of the pelvis. The OSTA was calculated with 
      a formula based on weight and age. Data were analyzed with descriptive statistics 
      and tests of difference. Receiver operating characteristic analysis was used to 
      determine optimum cutoff values, sensitivity, and specificity of screening 
      methods. Discriminative abilities of different screening tools were compared with 
      the area under the curve (AUC). RESULTS: There were significant differences in 
      BMD at all sites (lumbar spine, femoral neck, trochanter, and total hip) and in 
      SI between the fracture and non-fracture groups (P < 0.05). There was no 
      significant difference in OSTA between the groups (P > 0.05). The area under the 
      curve was 0.747 (95% CI: 0.680-0.813) for lumbar spine BMD, 0.699 (95% CI: 
      0.633-0.764) for total hip BMD, 0.659 (95% CI: 0.589-0.729) for femoral neck BMD, 
      0.631 (95% CI: 0.557-0.704) for trochanter BMD, 0.534 (95% CI: 0.459-0.610) for 
      OSTA, 0.636 (95% CI: 0.564-0.709) for SI, and 0.795 (95% CI: 0.734-0.857) for 
      OSTA plus SI. The AUC for combined OSTA plus SI was significantly superior to 
      other parameters besides BMD of the lumbar spine. CONCLUSIONS: The combination of 
      OSTA plus SI could be a clinical alternative tool for screening of hip fracture 
      risk in large diabetic populations. These tests are inexpensive and simple to 
      perform and could be especially useful in areas where BMD measurement is not 
      accessible.
FAU - Liu, Zhenyu
AU  - Liu Z
AD  - Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical 
      University, Yongan Road No.95, Xicheng District, 100050, Beijing, China.
FAU - Gao, Hua
AU  - Gao H
AD  - Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical 
      University, Yongan Road No.95, Xicheng District, 100050, Beijing, China.
FAU - Bai, Xiaodong
AU  - Bai X
AD  - Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical 
      University, Yongan Road No.95, Xicheng District, 100050, Beijing, China.
FAU - Zhao, Liang
AU  - Zhao L
AD  - Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical 
      University, Yongan Road No.95, Xicheng District, 100050, Beijing, China.
FAU - Li, Yadong
AU  - Li Y
AD  - Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical 
      University, Yongan Road No.95, Xicheng District, 100050, Beijing, China.
FAU - Wang, Baojun
AU  - Wang B
AD  - Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical 
      University, Yongan Road No.95, Xicheng District, 100050, Beijing, China. 
      doczhyl@hotmail.com.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20170303
PL  - England
TA  - J Orthop Surg Res
JT  - Journal of orthopaedic surgery and research
JID - 101265112
SB  - IM
MH  - Absorptiometry, Photon
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Density
MH  - Diabetes Mellitus, Type 2/*complications/physiopathology
MH  - Female
MH  - Hip Fractures/*etiology/physiopathology
MH  - Hip Joint/diagnostic imaging/physiopathology
MH  - Humans
MH  - Lumbar Vertebrae/diagnostic imaging/physiopathology
MH  - Middle Aged
MH  - Osteoporosis, Postmenopausal/complications/diagnostic imaging
MH  - Osteoporotic Fractures/*etiology/physiopathology
MH  - ROC Curve
MH  - Radiography
MH  - Retrospective Studies
MH  - Risk Assessment/methods
MH  - Self-Assessment
MH  - Severity of Illness Index
PMC - PMC5335822
OTO - NOTNLM
OT  - Hip fracture
OT  - Self-Assessment Tool for Asians
OT  - Singh Index
OT  - Type 2 diabetes mellitus
EDAT- 2017/03/04 06:00
MHDA- 2017/05/23 06:00
PMCR- 2017/03/03
CRDT- 2017/03/04 06:00
PHST- 2016/11/17 00:00 [received]
PHST- 2017/02/15 00:00 [accepted]
PHST- 2017/03/04 06:00 [entrez]
PHST- 2017/03/04 06:00 [pubmed]
PHST- 2017/05/23 06:00 [medline]
PHST- 2017/03/03 00:00 [pmc-release]
AID - 10.1186/s13018-017-0539-6 [pii]
AID - 539 [pii]
AID - 10.1186/s13018-017-0539-6 [doi]
PST - epublish
SO  - J Orthop Surg Res. 2017 Mar 3;12(1):37. doi: 10.1186/s13018-017-0539-6.