PMID- 28255274
OWN - NLM
STAT- MEDLINE
DCOM- 20171107
LR  - 20181113
IS  - 1449-2288 (Electronic)
IS  - 1449-2288 (Linking)
VI  - 13
IP  - 2
DP  - 2017
TI  - Hyperhomocysteinemia Exacerbates Cisplatin-induced Acute Kidney Injury.
PG  - 219-231
LID - 10.7150/ijbs.16725 [doi]
AB  - Hyperhomocysteinemia (HHcy) has been linked to several clinical manifestations 
      including chronic kidney disease. However, it is not known whether HHcy has a 
      role in the development of acute kidney injury (AKI). In the present study, we 
      reported that HHcy mice developed more severe renal injury after cisplatin 
      injection and ischemia-reperfusion injury shown as more severe renal tubular 
      damage and higher serum creatinine. In response to cisplatin, HHcy mice showed 
      more prevalent tubular cell apoptosis and decreased tubular cell proliferation. 
      Mechanistically, a heightened ER stress and a reduced Akt activity were observed 
      in kidney tissues of HHcy mice after cisplatin injection. Stimulating cultured 
      NRK-52E cells with Hcy significantly increased the fraction of cells in G2/M 
      phase and cell apoptosis together with decreased Akt kinase activity. Akt agonist 
      IGF-1 rescued HHcy-induced cell cycle arrest and cell apoptosis. In conclusion, 
      the present study provides evidence that HHcy increases the sensitivity and 
      severity of AKI.
FAU - Long, Yanjun
AU  - Long Y
AD  - State Key Laboratory of Organ Failure Research, National Clinical Research Center 
      of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical 
      University, Guangzhou, P.R. China;; Division of Nephrology, Guizhou Provincial 
      People's Hospital, Guizhou Provincial Institute of Nephritic & Urinary Disease, 
      Guiyang, P.R. China.
FAU - Zhen, Xin
AU  - Zhen X
AD  - State Key Laboratory of Organ Failure Research, National Clinical Research Center 
      of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical 
      University, Guangzhou, P.R. China.
FAU - Zhu, Fengxin
AU  - Zhu F
AD  - State Key Laboratory of Organ Failure Research, National Clinical Research Center 
      of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical 
      University, Guangzhou, P.R. China.
FAU - Hu, Zheng
AU  - Hu Z
AD  - State Key Laboratory of Organ Failure Research, National Clinical Research Center 
      of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical 
      University, Guangzhou, P.R. China.
FAU - Lei, Wenjing
AU  - Lei W
AD  - State Key Laboratory of Organ Failure Research, National Clinical Research Center 
      of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical 
      University, Guangzhou, P.R. China.
FAU - Li, Shuang
AU  - Li S
AD  - State Key Laboratory of Organ Failure Research, National Clinical Research Center 
      of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical 
      University, Guangzhou, P.R. China.
FAU - Zha, Yan
AU  - Zha Y
AD  - Division of Nephrology, Guizhou Provincial People's Hospital, Guizhou Provincial 
      Institute of Nephritic & Urinary Disease, Guiyang, P.R. China.
FAU - Nie, Jing
AU  - Nie J
AD  - State Key Laboratory of Organ Failure Research, National Clinical Research Center 
      of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical 
      University, Guangzhou, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170206
PL  - Australia
TA  - Int J Biol Sci
JT  - International journal of biological sciences
JID - 101235568
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Acute Kidney Injury/*chemically induced/*etiology/metabolism
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Cell Line
MH  - Cell Proliferation/drug effects
MH  - Cisplatin/*adverse effects
MH  - Endoplasmic Reticulum Stress/drug effects
MH  - Homocysteine/blood
MH  - Hyperhomocysteinemia/blood/*complications/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Rats
PMC - PMC5332876
OTO - NOTNLM
OT  - AKI
OT  - ER stress.
OT  - Hyperhomocysteinemia
OT  - apoptosis
OT  - cell proliferation
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2017/03/04 06:00
MHDA- 2017/11/08 06:00
PMCR- 2017/01/01
CRDT- 2017/03/04 06:00
PHST- 2016/07/04 00:00 [received]
PHST- 2016/10/21 00:00 [accepted]
PHST- 2017/03/04 06:00 [entrez]
PHST- 2017/03/04 06:00 [pubmed]
PHST- 2017/11/08 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - ijbsv13p0219 [pii]
AID - 10.7150/ijbs.16725 [doi]
PST - epublish
SO  - Int J Biol Sci. 2017 Feb 6;13(2):219-231. doi: 10.7150/ijbs.16725. eCollection 
      2017.