PMID- 28255464
OWN - NLM
STAT- MEDLINE
DCOM- 20170829
LR  - 20181113
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2017
DP  - 2017
TI  - Impairments in Brain Perfusion, Metabolites, Functional Connectivity, and 
      Cognition in Severe Asymptomatic Carotid Stenosis Patients: An Integrated MRI 
      Study.
PG  - 8738714
LID - 10.1155/2017/8738714 [doi]
LID - 8738714
AB  - Carotid artery stenosis without transient ischemic attack (TIA) or stroke is 
      considered as "asymptomatic." However, recent studies have demonstrated that 
      these asymptomatic carotid artery stenosis (aCAS) patients had cognitive 
      impairment in tests of executive function, psychomotor speed, and memory, 
      indicating that "asymptomatic" carotid stenosis may not be truly asymptomatic. In 
      this study, when 19 aCAS patients compared with 24 healthy controls, aCAS 
      patients showed significantly poorer performance on global cognition, memory, and 
      executive function. By utilizing an integrated MRI including pulsed arterial spin 
      labeling (pASL) MRI, Proton MR Spectroscopy (MRS), and resting-state functional 
      MRI (R-fMRI), we also found that aCAS patients suffered decreased cerebral blood 
      flow (CBF) mainly in the Left Frontal Gyrus and had decreased NAA/Cr ratio in the 
      left hippocampus and decreased connectivity to the posterior cingulate cortex 
      (PCC) in the anterior part of default mode network (DMN).
FAU - Wang, Tao
AU  - Wang T
AD  - Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, China.
FAU - Xiao, Feng
AU  - Xiao F
AUID- ORCID: 0000-0003-2929-1844
AD  - Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
FAU - Wu, Guangyao
AU  - Wu G
AUID- ORCID: 0000-0002-0456-3682
AD  - Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
FAU - Fang, Jian
AU  - Fang J
AUID- ORCID: 0000-0003-1225-1432
AD  - Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
FAU - Sun, Zhenmeng
AU  - Sun Z
AUID- ORCID: 0000-0002-8876-494X
AD  - Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
FAU - Feng, Hongliang
AU  - Feng H
AUID- ORCID: 0000-0003-3291-7780
AD  - Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, China.
FAU - Zhang, Junjian
AU  - Zhang J
AUID- ORCID: 0000-0002-4557-5137
AD  - Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, China.
FAU - Xu, Haibo
AU  - Xu H
AUID- ORCID: 0000-0002-8451-8979
AD  - Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170201
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
SB  - IM
MH  - Aged
MH  - Brain/blood supply/*metabolism/*physiopathology
MH  - Brain Mapping
MH  - Carotid Stenosis/complications/*metabolism/*physiopathology
MH  - Cognitive Dysfunction/complications/*metabolism/*physiopathology
MH  - Female
MH  - Gyrus Cinguli/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/physiopathology
MH  - Neuropsychological Tests
PMC - PMC5309400
COIS- There is no conflict of interests.
EDAT- 2017/03/04 06:00
MHDA- 2017/08/30 06:00
PMCR- 2017/02/01
CRDT- 2017/03/04 06:00
PHST- 2016/09/23 00:00 [received]
PHST- 2016/11/15 00:00 [revised]
PHST- 2016/12/07 00:00 [accepted]
PHST- 2017/03/04 06:00 [entrez]
PHST- 2017/03/04 06:00 [pubmed]
PHST- 2017/08/30 06:00 [medline]
PHST- 2017/02/01 00:00 [pmc-release]
AID - 10.1155/2017/8738714 [doi]
PST - ppublish
SO  - Neural Plast. 2017;2017:8738714. doi: 10.1155/2017/8738714. Epub 2017 Feb 1.